SwePub - search: WFRF:(Lähdevirta J.)

Enumeration	Reference	Cover	Find
1.	Poutiainen, E., et al. (author) Cognitive decline in patients with symptomtic HIV-1 infection : No decline in asymptomatic infection 1996 In: Acta Neurologica Scandinavica. - 0001-6314 .- 1600-0404. ; 93:6, s. 421-7 Journal article (peer-reviewed)abstract Thirty-six HIV-1-infected predominantly well-functioning subjects were followed up for one year by repeated neuropsychological, clinical neurological, neuroradiological, and immunological examinations. Changes in cognitive performance related to the severity of HIV-1 infection as well as to neuroradiological or immunological changes were studied. A decline in cognitive speed and flexibility was found in symptomatic subjects (ARC, AIDS). The impairment was especially pronounced in patients with progression of brain atrophy. These findings suggest a brain pathology underlying the cognitive decline in ambulatory outpatients with symptomatic HIV-1 infection. A practice effect was found in asymptomatic subjects (ASX, LAS) and in those with unchanged CT/MRI scans. No systematic relationship was found between cognitive change and immunological change.

Poutiainen, E., et al. (author)
Cognitive decline in patients with symptomtic HIV-1 infection : No decline in asymptomatic infection
1996
In: Acta Neurologica Scandinavica. - 0001-6314 .- 1600-0404. ; 93:6, s. 421-7
Journal article (peer-reviewed)abstract
- Thirty-six HIV-1-infected predominantly well-functioning subjects were followed up for one year by repeated neuropsychological, clinical neurological, neuroradiological, and immunological examinations. Changes in cognitive performance related to the severity of HIV-1 infection as well as to neuroradiological or immunological changes were studied. A decline in cognitive speed and flexibility was found in symptomatic subjects (ARC, AIDS). The impairment was especially pronounced in patients with progression of brain atrophy. These findings suggest a brain pathology underlying the cognitive decline in ambulatory outpatients with symptomatic HIV-1 infection. A practice effect was found in asymptomatic subjects (ASX, LAS) and in those with unchanged CT/MRI scans. No systematic relationship was found between cognitive change and immunological change.

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