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- Poutiainen, E., et al.
(author)
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Cognitive decline in patients with symptomtic HIV-1 infection : No decline in asymptomatic infection
- 1996
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In: Acta Neurologica Scandinavica. - 0001-6314 .- 1600-0404. ; 93:6, s. 421-7
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Journal article (peer-reviewed)abstract
- Thirty-six HIV-1-infected predominantly well-functioning subjects were followed up for one year by repeated neuropsychological, clinical neurological, neuroradiological, and immunological examinations. Changes in cognitive performance related to the severity of HIV-1 infection as well as to neuroradiological or immunological changes were studied. A decline in cognitive speed and flexibility was found in symptomatic subjects (ARC, AIDS). The impairment was especially pronounced in patients with progression of brain atrophy. These findings suggest a brain pathology underlying the cognitive decline in ambulatory outpatients with symptomatic HIV-1 infection. A practice effect was found in asymptomatic subjects (ASX, LAS) and in those with unchanged CT/MRI scans. No systematic relationship was found between cognitive change and immunological change.
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