| 1. |
- Andersson, Hanna, 1991-, et al.
(author)
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The negative footprint illusion is exacerbated by the numerosity of environment-friendly additions: unveiling the underpinning mechanisms
- 2024
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In: Journal of Cognitive Psychology. - : Taylor & Francis. - 2044-5911 .- 2044-592X. ; 36:2, s. 295-307
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Journal article (peer-reviewed)abstract
- The addition of environmentally friendly items to conventional items sometimes leads people to believe that the carbon footprint of the entire set decreases rather than increases. This negative footprint illusion is supposedly underpinned by an averaging bias: people base environmental impact estimates not on the total impact of items but on their average. Here, we found that the illusion's magnitude increased with the addition of a greater number of "green" items when the number of conventional items remained constant (Studies 1 and 2), supporting the averaging-bias account. We challenged this account by testing what happens when the number of items in the conventional and "green" categories vary while holding the ratio between the two categories constant (Study 3). At odds with the averaging-bias account, the magnitude of the illusion increased as the category size increased, revealing a category-size bias, and raising questions about the interplay between these biases in the illusion.
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| 2. |
- Chahal, Gurdeep, et al.
(author)
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A Complex Connection Between the Diversity of Human Gastric Mucin O-Glycans, Helicobacter pylori Binding, Helicobacter Infection and Fucosylation
- 2022
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In: Molecular & Cellular Proteomics. - : Elsevier BV. - 1535-9476 .- 1535-9484. ; 21:11
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Journal article (peer-reviewed)abstract
- Helicobacter pylori colonizes the stomach of half of the human population. Most H. pylori are located in the mucus layer, which is mainly comprised by glycosylated mucins. Using mass spectrometry, we identified 631 glycans (whereof 145 were fully characterized and the remainder assigned as compositions) on mucins isolated from 14 Helicobacter spp.-infected and 14 Helicobacter spp.-noninfected stomachs. Only six identified glycans were common to all individuals, from a total of 60 to 189 glycans in each individual. An increased number of unique glycan structures together with an increased intra-individual diversity and larger interindividual variation were identified among O-glycans from Helicobacter spp.-infected stomachs compared with noninfected stom-achs. H. pylori strain J99, which carries the blood group antigen-binding adhesin (BabA), the sialic acid-binding adhesin (SabA), and the LacdiNAc-binding adhesin, bound both to Lewis b (Leb)-positive and Leb-negative mucins. Among Leb-positive mucins, H. pylori J99 bind-ing was higher to mucins from Helicobacter spp.-infected individuals than noninfected individuals. Statistical corre-lation analysis, binding experiments with J99 wt, and J99 Delta babA Delta sabA and inhibition experiments using syn-thetic glycoconjugates demonstrated that the differences in H. pylori-binding ability among these four groups were governed by BabA-dependent binding to fucosylated structures. LacdiNAc levels were lower in mucins that bound to J99 lacking BabA and SabA than in mucins that did not, suggesting that LacdiNAc did not significantly contribute to the binding. We identified 24 O-glycans from Leb-negative mucins that correlated well with H. pylori binding whereof 23 contained alpha 1,2-linked fucosylation. The large and diverse gastric glycan library identified, including structures that correlated with H. pylori binding, could be used to select glycodeterminants to experimen-tally investigate further for their importance in host- pathogen interactions and as candidates to develop glycan-based therapies.
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| 3. |
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| 4. |
- Davies, Roy, et al.
(author)
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Three applications of virtual reality for brain injury rehabilitation of daily tasks
- 2002
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In: Proceedings of the 4th International Conference on Disability, Virtual Reality & Associated Technologies. - 0704911434 ; , s. 93-100
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Conference paper (peer-reviewed)abstract
- Part of the process of rehabilitation after a brain injury is the relearning of various daily tasks such as preparing food, managing finances, getting from one place to another and so forth. These tasks require learning on all levels from physical to cognitive. Remembering a PIN code for a bank card, for example, can become automatic and ‘in the fingers’ after much repetition. However, other tasks require a certain cognitive process, for example, procedures must be followed, quantities estimated, numbers of items remembered or dangerous situations avoided. Even in these cases, repetition of the task many times can help fix the important aspects in the mind. This paper describes three applications of a Virtual Reality based method of rehabilitation which are a part of a larger project to investigate the potential and pitfalls of Virtual Reality technology as a complement to physical training in Brain Injury Rehabilitation. Virtual Reality has the advantage of providing a safe, controlled and highly repeatable environment that a patient can experience in a relaxed manner before having to encounter the potentially dangerous or stressful real environment. The three applications considered here are: kitchen work, an automatic teller machine (ATM) and finding ones way in a complex environment.
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| 5. |
- Dehghannejad, Mahdieh, 1979-, et al.
(author)
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High-resolution reflection seismic imaging for the planning of a double-train-track tunnel in the city of Varberg, southwest Sweden
- 2017
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In: Near Surface Geophysics. - : EUROPEAN ASSOC GEOSCIENTISTS & ENGINEERS. - 1569-4445 .- 1873-0604. ; 15:3, s. 226-240
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Journal article (peer-reviewed)abstract
- A newly developed broadband digital-based seismic landstreamer system was employed for the planning of a double-train-track tunnel in the city of Varberg, southwest Sweden. Twenty-five seismic profiles, totalling more than 7.5 km of data, were acquired using a 2-to 4-m receiver and source spacing. At places where it was not possible to move the streamer such as road crossings, wireless recorders connected to 28-Hz geophones were used. In addition to the earlier refraction data analysis and first-break traveltime tomographic modelling, reflection processing of the data was considered in this study, given the realisation of reflections in raw shot gathers and their good quality. Bedrock is strongly reflective in most cases but is not evident in the sections when it gets near the surface. Bedrock undulation is noticeable in most reflection sections, and at one occasion, strong diffraction is observed in the bedrock or near to it. The diffraction is originated, not known during the survey, from a 400-m3 cylindrical (of about 3-m-height and 13-m-diameter) concrete-made fire-protection water tank situated in the bedrock and used in emergency situations. Reflection seismic data greatly complement the tomographic models and support deep bedrock where the excavation of the tunnel is planned in downtown Varberg. This interpretation implies different reinforcements and tunnel construction methods (e.g., roofed concrete) at this section of the tunnel. In addition, weakness zones associated with fracture systems are inferred from the reflection characteristics and in conjunction with the velocity models requiring verification by additional boreholes.
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| 6. |
- Ericson, E., et al.
(author)
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Hepatic patatin-like phospholipase domain-containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans
- 2022
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In: Hepatology communications.. - : Ovid Technologies (Wolters Kluwer Health). - 2471-254X. ; 6:10, s. 2689-2701
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Journal article (peer-reviewed)abstract
- In nonalcoholic fatty liver disease (NAFLD) the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 variant is a contributor. In mice, the Pnpla3 148M variant accumulates on lipid droplets and probably leads to sequestration of a lipase cofactor leading to impaired mobilization of triglycerides. To advance our understanding of the localization and abundance of PNPLA3 protein in humans, we used liver biopsies from patients with NAFLD to investigate the link to NAFLD and the PNPLA3 148M genotype. We experimentally qualified an antibody against human PNPLA3. Hepatic PNPLA3 protein fractional area and localization were determined by immunohistochemistry in biopsies from a well-characterized NAFLD cohort of 67 patients. Potential differences in hepatic PNPLA3 protein levels among patients related to degree of steatosis, lobular inflammation, ballooning, and fibrosis, and PNPLA3 I148M gene variants were assessed. Immunohistochemistry staining in biopsies from patients with NAFLD showed that hepatic PNPLA3 protein was predominantly localized to the membranes of small and large lipid droplets in hepatocytes. PNPLA3 protein levels correlated strongly with steatosis grade (p = 0.000027) and were also significantly higher in patients with lobular inflammation (p = 0.009), ballooning (p = 0.022), and significant fibrosis (stage 2-4, p = 0.014). In addition, PNPLA3 levels were higher in PNPLA3 rs738409 148M (CG, GG) risk allele carriers compared to 148I (CC) nonrisk allele carriers (p = 0.0029). Conclusion: PNPLA3 protein levels were associated with increased hepatic lipid content and disease severity in patients with NAFLD and were higher in PNPLA3 rs738409 (148M) risk allele carriers. Our hypothesis that increased hepatic levels of PNPLA3 may be part of the pathophysiological mechanism of NAFLD is supported.
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| 7. |
- Gustavsson, Simon T., et al.
(author)
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Nicotinamide prevents retinal vascular dropout in a rat model of ocular hypertension and supports ocular blood supply in glaucoma patients
- 2023
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In: Investigative Ophthalmology and Visual Science. - : Association for Research in Vision and Ophthalmology (ARVO). - 0146-0404 .- 1552-5783. ; 64
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Journal article (peer-reviewed)abstract
- PURPOSE. To investigate whether nicotinamide (NAM) modulates retinal vasculature in glaucoma.METHODS. This was a prospective controlled clinical trial investigating animal and human histopathology. Participants included normotensive and ocular hypertensive rats, postmortem human ocular tissue, glaucoma patients (n = 90), and healthy controls (n = 30). The study utilized histopathology, computer-assisted retinal vasculature analysis, optical coherence tomography angiography (OCTA), and NAM treatment. The main outcome measures included retinal vascular parameters in rats as assessed by AngioTool; retinal vasculature integrity in rats and humans as assessed by histopathology, antibody-staining, and ImageJ-based measurements; and retinal perfusion density (PD) and flux index in humans as assessed by OCTA.RESULTS. A number of vessel parameters were altered in ocular hypertension/glaucoma compared to healthy controls. NAM treatment improved the retinal vasculature in ocular hypertensive rats, with an increase in mean vessel area, percentage area covered by vessels, total vessel length, total junctions, and junction density as assessed by AngioTool (all P < 0.05); vessel wall integrity as assessed by VE-cadherin antibody staining was also improved (P < 0.01). In humans, as assessed by OCTA, increases in PD in the optic nerve head and macula complete image (0.7%, P = 0.04 and 1.0%, P = 0.002, respectively) in healthy controls, and an increase in the temporal quadrant of the macula (0.7%, P = 0.02) in glaucoma patients was seen after NAM treatment.CONCLUSIONS. NAM can prevent retinal vascular damage in an animal model of glaucoma. After NAM treatment, glaucoma patients and healthy controls demonstrated a small increase in retinal vessel parameters as assessed by OCTA.
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| 8. |
- Holmgren, Mattias, 1991-, et al.
(author)
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Can the negative footprint illusion be eliminated by summative priming?
- 2021
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In: Journal of Cognitive Psychology. - : Taylor & Francis. - 2044-5911 .- 2044-592X. ; 33:3, s. 337-356
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Journal article (peer-reviewed)abstract
- People’s belief that one or more environmentally friendly items that are added to a set of conventional items can reduce the total environmental impact of these items (the negative footprint illusion) could lead to unwanted environmental consequences. An averaging bias seems to underpin this illusion: people make their estimates based on the average of the environmental impact produced by the items rather than the accumulated sum. We report four studies that used various priming manipulations to explore whether people’s preoccupation to think in terms of an average can be eliminated by fostering a summative mindset. The results demonstrate that participants avoid succumbing to the negative footprint illusion when the critical judgment task is preceded by tasks that engender a summation judgment. Our evidence indicates that the negative footprint illusion can be tempered when a primed concept (summation) is used adaptively on subsequent judgments, thereby correcting for bias in environmental judgments.
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| 9. |
- Holmgren, Mattias, Doktorand, 1991-, et al.
(author)
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Eliminating the Negative Footprint Illusion by Fostering a Summative Mindset using a Transfer Paradigm
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Other publication (other academic/artistic)abstract
- People’s belief that an environmentally friendly item that is added to a set of conventional items has the ability to reduce the total environmental impact of these items could lead to unwanted environmental consequences. An averaging bias seems to underpin this negative footprint illusion: people make their estimates based on the average of the environmental impact produced by the items rather than their accumulative sum. We report a study using a problem-solving transfer paradigm to explore if this preoccupation to think in terms of an average can be eliminated by fostering a summative mindset. The results demonstrate that, participants can correctly estimate that environmental impact will increase when a “green” car is added to a set of petrol cars, but only when this task is preceded by a task that engenders a summation judgment. Our evidence indicates that the negative footprint illusion can be tempered by problem-solving transfer whereby a primed concept (summation) is used adaptively on subsequent judgments, thereby correcting for bias in environmental judgments.
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| 10. |
- Joelsson, Tobias, et al.
(author)
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Flow and Temperature Distribution in an Experimental Engine: LES Studies and Thermographic Imaging
- 2010
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In: SAE technical paper series. - 0148-7191.
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Journal article (peer-reviewed)abstract
- Temperature stratification plays an important role in HCCI combustion. The onsets of auto-ignition and combustion duration are sensitive to the temperature field in the engine cylinder. Numerical simulations of HCCI engine combustion are affected by the use of wall boundary conditions, especially the temperature condition at the cylinder and piston walls. This paper reports on numerical studies and experiments of the temperature field in an optical experimental engine in motored run conditions aiming at improved understanding of the evolution of temperature stratification in the cylinder. The simulations were based on Large-Eddy-Simulation approach which resolves the unsteady energetic large eddy and large scale swirl and tumble structures. Two dimensional temperature experiments were carried out using laser induced phosphorescence with thermographic phosphors seeded to the gas in the cylinder. The results revealed different mechanisms for the development of temperature stratification: intake gas and residual gas mixing, heat transfer in the wall boundary layer, compression of the charge, and large scale flow transport. The sensitivity of LES results to different wall boundary conditions and inflow conditions was analyzed.
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