| 1. |
- Aad, G., et al.
(författare)
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- 2011
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swepub:Mat__t (refereegranskat)
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| 2. |
- Wanhainen, Anders, et al.
(författare)
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The effect of ticagrelor on growth of small abdominal aortic aneurysms-a randomized controlled trial
- 2020
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Ingår i: Cardiovascular Research. - : Oxford University Press (OUP). - 0008-6363 .- 1755-3245. ; 116:2, s. 450-456
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Tidskriftsartikel (refereegranskat)abstract
- Aims: To evaluate if ticagrelor, an effective platelet inhibitor without known non-responders, could inhibit growth of small abdominal aortic aneurysms (AAAs). Methods and results: In this multi-centre randomized controlled trial, double-blinded for ticagrelor and placebo, acetylic salicylic acid naive patients with AAA and with a maximum aortic diameter 35-49mm were included. The primary outcome was mean reduction in log-transformed AAA volume growth rate (%) measured with magnetic resonance imaging (MRI) at 12months compared with baseline. Secondary outcomes include AAA-diameter growth rate and intraluminal thrombus (ILT) volume enlargement rate. A total of 144 patients from eight Swedish centres were randomized (72 in each group). MRI AAA volume increase was 9.1% for the ticagrelor group and 7.5% for the placebo group (P=0.205) based on intention-to-treat analysis, and 8.5% vs. 7.4% in a per-protocol analysis (P=0.372). MRI diameter change was 2.5mm vs. 1.8mm (P=0.113), US diameter change 2.3mm vs. 2.2mm (P=0.778), and ILT volume change 12.9% vs. 10.4% (P=0.590). Conclusion: In this RCT, platelet inhibition with ticagrelor did not reduce growth of small AAAs. Whether the ILT has an important pathophysiological role for AAA growth cannot be determined based on this study due to the observed lack of thrombus modulating effect of ticagrelor.
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| 3. |
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| 4. |
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| 5. |
- Krmar, R T, et al.
(författare)
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Acute renal failure in dense deposit disease: complete recovery after combination therapy with immunosuppressant and plasma exchange.
- 2011
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Ingår i: Clinical Nephrology. - 0301-0430. ; 75:S1, s. 4-10
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Tidskriftsartikel (refereegranskat)abstract
- We describe the clinical course of a female adolescent who was followed because of isolated microhematuria and hypocomplementemia before admission to hospital with a sudden onset of acute renal failure. At presentation, she exhibited complement consumption through the complement alternative pathway (AP) while other serologic tests were negative. Renal biopsy revealed dense deposit disease (DDD) with a crescentic pattern. Intravenous methylprednisolone, followed by plasma exchange (PE), and intravenous cyclophosphamide pulses were started shortly after admission. C3NeF and anti-factor H antibody tests were negative. Serum factor H and I levels were normal as well as factor H activity. Screening for mutation in the factor H gene revealed the H402 allele variant. Clinical remission, defined as normalization in renal function and in the activity levels of the complement AP, was noted at one month post-presentation and throughout the follow-up. A repeat renal biopsy showed the disappearance of crescent formation, whereas electron microscopy revealed no regression in dense transformation of the lamina densa. In summary, our patient was successfully treated with immunosuppressant and PE. The absence of known factors associated with DDD suggests that, in this particular case, other regulatory mechanisms of complement AP might have been involved in the disease process.
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| 6. |
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| 7. |
- Nauert, A., et al.
(författare)
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Experimental analysis of flashback in lean premixed swirling flames: conditions close to flashback
- 2007
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Ingår i: Experiments in Fluids. - : Springer Science and Business Media LLC. - 1432-1114 .- 0723-4864. ; 43:1, s. 89-100
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Tidskriftsartikel (refereegranskat)abstract
- Swirling lean premixed flames are of practical relevance due to their potential for low nitric oxide (NOx) emissions. Unfortunately, these flames have various drawbacks. One critical attribute is the possibility for flashback of the reacting flow into the nozzle. Advanced numerical simulations should be able in the future to predict the transition from stable flames to flashback. For a better understanding of the process itself and for validation of numerical simulation a well-documented generic benchmark experiment is needed. This study presents a burner configuration that has already been studied extensively in the past. By minor geometrical adaptations, and via the possibility to vary the swirl intensity in a controlled way, the transition from stable flames to flashback is now accessible to detailed characterisation using advanced laser diagnostics. In a first part of this study the different states of the flame were classified. In the second part, both a stable and a precessing flame very close to flash back were compared in terms of flow and scalar field. The variation of the swirl intensity on the flame is discussed. Because the flame is strongly influenced by its inflow conditions additional velocity measurements inside the nozzle were carried out. This is of special importance for subsequent numerical simulations to match the experimental conditions. The quantitative investigation of the flame during flashback is subjected to consecutive experiments where planar laser diagnostics at high repetition rates will be exploited.
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| 8. |
- Nogenmyr, Karl-Johan, et al.
(författare)
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Large Eddy Simulation and Experiments of Stratified Lean Premixed Methane/Air Turbulent Flames
- 2007
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Ingår i: Proceedings of the Combustion Institute. - : Elsevier BV. - 1540-7489. ; 31:1, s. 1467-1475
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a joint large eddy simulation and laser diagnostic investigation of premixed turbulent low swirl flames. A lean premixed methane/air mixture, of the equivalence ratio 0.60-0.66, is injected from a 50 mm diameter low swirl burner to a low speed co-flowing air at room temperature and pressure. The level-set G-equation is employed to simulate the inner layer flame front. Flamelet chemistry is used to determine the flame properties in the reactive zones. Mixing and heat transfer in the post-flame zone down-stream are modeled using transport equations. In addition to large eddy simulation, simultaneous 2-D laser induced fluorescence of OH and 2-D particle image velocimetry are used to characterize the basic flame structure. Laser Doppler velocimetry is employed to further analyze the flow velocity along the central axis above the burner, and 2-D filtered Rayleigh scattering is used to measure the temperature field in the lower part of the flame. A bowl-shaped, highly wrinkled turbulent flame is stabilized at a position about one-half diameter above the burner. The flame consists of two distinct parts; around the burner axis, a premixed flame with uniform mixture fraction is stabilized in the low speed flow region induced by the inflow swirl; off the axis of the burner, a stratified lean premixed flame is found in the shear layer of the flow field. Flame holes (local extinction) owing to overly lean mixtures are observed in the off-axis lean stratified part of the flame. A unified level-set G-equation is developed to model the flame holes. The basic flow and flame structure from the model simulations are compared to the laser diagnostic measurements; the height of flame stabilization (lift-off height), the mean temperature profile, and the mean axial and radial velocity components together with rms velocity components are in fairly good agreement with measurement data. © 2006 The Combustion Institute. Published by Elsevier Inc. All rights reserved.
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| 9. |
- Wanhainen, Anders, et al.
(författare)
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Outcome of the Swedish Nationwide Abdominal Aortic Aneurysm Screening Program
- 2016
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Ingår i: Circulation. - 0009-7322 .- 1524-4539. ; 134:16, s. 1141-1148
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Tidskriftsartikel (refereegranskat)abstract
- Background: A general abdominal aortic aneurysm (AAA) screening program, targeting 65-year-old men, has gradually been introduced in Sweden since 2006 and reached nationwide coverage in 2015. The aim of this study was to determine the outcome of this program. Methods: Data on the number of invited and examined men, screening-detected AAAs, AAAs operated on, and surgical outcome were retrieved from all 21 Swedish counties for the years 2006 through 2014. AAA-specific mortality data were retrieved from the Swedish Cause of Death Registry. A linear regression analysis was used to estimate the effect on AAA-specific mortality among all men 65 years of age for the observed time period. The long-term effects were projected by using a validated Markov model. Results: Of 302957 men aged 65 years invited, 84% attended. The prevalence of screening-detected AAA was 1.5%. After a mean of 4.5 years, 29% of patients with AAA had been operated on, with a 30-day mortality rate of 0.9% (1.3% after open repair and 0.3% after endovascular repair, P<0.001). The introduction of screening was associated with a significant reduction in AAA-specific mortality (mean, 4.0% per year of screening, P=0.020). The number needed to screen and the number needed to operate on to prevent 1 premature death were 667 and 1.5, respectively. With a total population of 9.5 million, the Swedish national AAA-screening program was predicted to annually prevent 90 premature deaths from AAA and to gain 577 quality-adjusted life-years. The incremental cost-efficiency ratio was estimated to be Euro7770 per quality-adjusted life-years. Conclusions: Screening 65-year-old men for AAA is an effective preventive health measure and is highly cost-effective in a contemporary setting. These findings confirm the results from earlier randomized controlled trials and model studies in a large population-based setting of the importance for future healthcare decision making.
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| 10. |
- Berrocal, E., et al.
(författare)
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Image transfer through the complex scattering turbid media
- 2006
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Ingår i: Laser Physics Letters. - : IOP Publishing. - 1612-2011 .- 1612-202X. ; 3:9, s. 464-467
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Tidskriftsartikel (refereegranskat)abstract
- Seeing through a turbid medium such as fog, mist or clouds is a fascinating idea that would find applications in a large range of fields from research to industry. The main difficulty of this challenging task is related to the complexity of the multiple of optical radiation propagated through an emsemble of scattering particles and/or droplets randomly distributed in a medium. To deal with this challenging problem to deal with a new Monte Carlo based method computational technique able to simulate image transfer through the complex inhomogenous turbid media. The model is able to identify the contribution of the scattering orders in the detected images for a particular medium. With the presented approach the simulation of laser propagation and image transfer of an object hidden within a turbid scattering medium has been performed. The results of simulation demonstrate a good agreement with the experimental results. The validation of the technique has been one by using several modeling samples of water polystyrenes spheres solutions.
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