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Träfflista för sökning "WFRF:(MALMBERG G) "

Search: WFRF:(MALMBERG G)

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  • Gupta, G., et al. (author)
  • Exploiting Mass Spectrometry to Unlock the Mechanism of Nanoparticle-Induced Inflammasome Activation
  • 2023
  • In: Acs Nano. - : AMER CHEMICAL SOC. - 1936-0851 .- 1936-086X. ; 17:17, s. 17451-17467
  • Journal article (peer-reviewed)abstract
    • Nanoparticles (NPs) elicit sterile inflammation, but the underlying signaling pathways are poorly understood. Here, we report that human monocytes are particularly vulnerable to amorphous silica NPs, as evidenced by single-cell-based analysis of peripheral blood mononuclear cells using cytometry by time-of-flight (CyToF), while silane modification of the NPs mitigated their toxicity. Using human THP-1 cells as a model, we observed cellular internalization of silica NPs by nanoscale secondary ion mass spectrometry (nanoSIMS) and this was confirmed by transmission electron microscopy. Lipid droplet accumulation was also noted in the exposed cells. Furthermore, time-of-flight secondary ion mass spectrometry (ToF-SIMS) revealed specific changes in plasma membrane lipids, including phosphatidylcholine (PC) in silica NP-exposed cells, and subsequent studies suggested that lysophosphatidylcholine (LPC) acts as a cell autonomous signal for inflammasome activation in the absence of priming with a microbial ligand. Moreover, we found that silica NPs elicited NLRP3 inflammasome activation in monocytes, whereas cell death transpired through a non-apoptotic, lipid peroxidation-dependent mechanism. Together, these data further our understanding of the mechanism of sterile inflammation.
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  • Venkatesan, M, et al. (author)
  • Erratum
  • 2019
  • In: The American journal of tropical medicine and hygiene. - : American Society of Tropical Medicine and Hygiene. - 1476-1645 .- 0002-9637. ; 100:3, s. 766-766
  • Journal article (peer-reviewed)
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  • Result 1-10 of 140
Type of publication
journal article (97)
conference paper (36)
research review (3)
reports (2)
other publication (1)
doctoral thesis (1)
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Type of content
peer-reviewed (117)
other academic/artistic (23)
Author/Editor
Malmberg, K (21)
Rydén, L. (15)
Malmberg, Bo (14)
Malmberg, Per, 1974 (14)
Ewing, Andrew G, 195 ... (11)
Berg, Stig (10)
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Malmberg, A (9)
Malmberg, P (7)
Martin, P. (6)
Cecconello, Marco (6)
Jönsson, Pär G. (6)
Spizzo, G. (6)
Nilsson, G (5)
Jennische, Eva, 1949 (5)
Lange, Stefan, 1948 (5)
Franz, P. (5)
Marrelli, L. (5)
Malmberg, Filip (5)
Norhammar, A. (5)
Allebeck, P (4)
Bolzonella, T (4)
Drake, James Robert (4)
Piovesan, P (4)
Sundell, J (4)
Dowlatshahi Pour, Ma ... (4)
Lahti, J (4)
Snieder, H. (4)
Karasev, Andrey (4)
Norén, Jörgen G, 194 ... (4)
Sigurdsson, G (4)
Paccagnella, R. (4)
Vuoksimaa, E (3)
Nilsson, O (3)
Almqvist, C (3)
Jonsson, B (3)
Béziat, V (3)
Cosentino, F (3)
Pershagen, G (3)
Gudnason, V (3)
Masucci, G (3)
Svensson, O (3)
Ahlberg, G (3)
Carlsson, G. (3)
Tuomilehto, J. (3)
Hedman, A (3)
Lincoff, AM (3)
Mahmood, S. (3)
Nordvall, L (3)
Renstrom, A (3)
Pedersen, N (3)
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University
Karolinska Institutet (66)
University of Gothenburg (24)
Royal Institute of Technology (18)
Uppsala University (18)
Chalmers University of Technology (14)
Jönköping University (13)
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Umeå University (6)
Mid Sweden University (5)
Lund University (4)
RISE (3)
Linköping University (2)
Högskolan Dalarna (2)
Luleå University of Technology (1)
Stockholm University (1)
Swedish National Heritage Board (1)
Karlstad University (1)
Swedish University of Agricultural Sciences (1)
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Language
English (136)
Swedish (4)
Research subject (UKÄ/SCB)
Medical and Health Sciences (33)
Natural sciences (19)
Engineering and Technology (15)
Social Sciences (8)

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