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1.	Bouyoucef, S E, et al. (author) Poster Session 2 : Monday 4 May 2015, 08 2015 In: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1 Journal article (peer-reviewed)
2.	Mandinov, L., et al. (author) Inhibition of in-stent restenosis by oral copper chelation in porcine coronary arteries 2006 In: American Journal of Physiology. Heart and Circulatory Physiology. - : American Physiological Society. - 0363-6135 .- 1522-1539. ; 291:6, s. H2692-H2697 Journal article (peer-reviewed)abstract Stress-induced release of IL-1 alpha and fibroblast growth factor-1 is dependent on intracellular copper and is a major driver of neointimal hyperplasia. Therefore, we assessed the effect of tetrathiomolybdate (TTM), a clinically proven copper chelator, on in-stent restenosis. Nine pigs were treated with TTM (5 mg/kg po) twice daily for 2 wk before stent implantation and for 4 wk thereafter, and nine pigs served as controls. In-stent restenosis was assessed by quantitative coronary angiography (QCA), intravascular ultrasound (IVUS), and histomorphometry. Serum ceruloplasmin activity was used as a surrogate marker of copper bioavailability. In TTM-treated animals, ceruloplasmin dropped 70 +/- 10% below baseline levels. Baseline characteristics were comparable in TTM-treated and control animals. At 4-wk follow-up, all parameters relevant to in-stent restenosis were significantly reduced in TTM-treated animals: minimal lumen diameter by QCA was 2.03 +/- 0.57 and 1.47 +/- 0.45 mm in TTM-treated and control animals, respectively (P less than 0.05), percent stenosis diameter was 39% less in TTM-treated animals (27.1 +/- 16.6% vs. 44.5 +/- 16.1%, P less than 0.05), minimal lumen area by IVUS was 60% larger in TTM-treated animals (4.27 +/- 1.56 vs. 2.67 +/- 1.19 mm(2), P less than 0.05), and neointimal volume by histomorphometry was 37% less in TTM-treated animals (34.9 +/- 11.5 vs. 55.2 +/- 19.6 mm(3), P less than 0.05). We conclude that systemic copper chelation with a clinically approved chelator significantly inhibits in-stent restenosis.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Costa, G. (1); Robinson, J. (1); Santos, J. (1); Smith, M. (1); Brünner, S. (1); Robinson, S. (1); show more...; Li, Q. (1); Soerensen, J. (1); Antoni, Gunnar (1); Sörensen, Jens (1); Reid, S. (1); Svensson, M. (1); Menendez, D. (1); Takahashi, K (1); Yousefi, B (1); Wikstrom, G. (1); Soares, J (1); Bottcher, M. (1); Fernandez, J. (1); Yla-Herttuala, S (1); Torres, M. (1); Martinez, C (1); Ferrari, C. (1); Reddy, P (1); Ramos, D (1); Lehner, S. (1); Cheng, B (1); Johnson, L (1); Akil, S (1); Hedeer, F (1); Engblom, H (1); Hindorf, C (1); Sayed, S (1); Soriano, E (1); Lubberink, Mark (1); Martin, W (1); Yoshida, H (1); Fukuda, H. (1); Westermark, P (1); Yokota, S. (1); Carlson, K (1); Rodriguez, L. (1); Kero, Tanja (1); Saraste, A. (1); Knuuti, J. (1); Morvan, M (1); Choqueux, C (1); Nicoletti, A (1); Cohen, M. (1); Rosales, S (1); show less...

University: Uppsala University (1); Linköping University (1)

Language: English (2)

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