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1.	Verberne, EA, et al. (author) JARID2 haploinsufficiency is associated with a clinically distinct neurodevelopmental syndrome 2021 In: Genetics in medicine : official journal of the American College of Medical Genetics. - : Elsevier BV. - 1530-0366. ; 23:2, s. 374-383 Journal article (peer-reviewed)
2.	Miloudi, Khalil, et al. (author) NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy 2019 In: Proceedings of the National Academy of Sciences of the United States of America. - : NATL ACAD SCIENCES. - 0027-8424 .- 1091-6490. ; 116:10, s. 4538-4547 Journal article (peer-reviewed)abstract Diabetic macular edema is a major complication of diabetes resulting in loss of central vision. Although heightened vessel leakiness has been linked to glial and neuronal-derived factors, relatively little is known on the mechanisms by which mature endothelial cells exit from a quiescent state and compromise barrier function. Here we report that endothelial NOTCH1 signaling in mature diabetic retinas contributes to increased vascular permeability. By providing both human and mouse data, we show that NOTCH1 ligands JAGGED1 and DELTA LIKE-4 are up-regulated secondary to hyperglycemia and activate both canonical and rapid noncanonical NOTCH1 pathways that ultimately disrupt endothelial adherens junctions in diabetic retinas by causing dissociation of vascular endothelial-cadherin from beta-catenin. We further demonstrate that neutralization of NOTCH1 ligands prevents diabetes-induced retinal edema. Collectively, these results identify a fundamental process in diabetes-mediated vascular permeability and provide translational rational for targeting the NOTCH pathway (primarily JAGGED1) in conditions characterized by compromised vascular barrier function.
3.	Rona, Peter A., et al. (author) Hydrothermal mineralization of Mid-Atlantic Ridge 10-27 degrees N 1982 In: Abstracts with programs (Geological Society of America). - 0016-7592. ; 14:7, s. 602- Journal article (other academic/artistic)

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Type of publication: journal article (3)

Type of content: peer-reviewed (2); other academic/artistic (1)

Author/Editor: Izumi, K. (1); Pfundt, R (1); Lieden, A (1); Lehman, A (1); Campeau, PM (1); Anderlid, BM (1); show more...; Boström, Kurt (1); Glatz, D (1); Bentley, Katie (1); Chaudhry, A (1); Widenfalk, Lennart (1); Kooy, RF (1); Stark, Z (1); Mannens, MMAM (1); Zarate, YA (1); Bedoukian, E (1); Isidor, B (1); Binet, Francois (1); Koolen, DA (1); Van Haelst, MM (1); Bosanko, KA (1); Maas, S (1); Miloudi, Khalil (1); Oubaha, Malika (1); Menard, Catherine (1); Dejda, Agnieszka (1); Guber, Vera (1); Cagnone, Gael (1); Wilson, Ariel M. (1); Tetreault, Nicolas (1); Mawambo, Gaelle (1); Chidiac, Rony (1); Delisle, Chantal (1); Buscarlet, Manuel (1); Cerani, Agustin (1); Crespo-Garcia, Sergi ... (1); Rezende, Flavio (1); Joyal, Jean-Sebastie ... (1); Mallette, Frederick ... (1); Gratton, Jean-Philip ... (1); Larrivee, Bruno (1); Sapieha, Przemyslaw (1); Robin, NH (1); Cronan, D.S. (1); Jenkins, W.J. (1); Rona, Peter A. (1); Mallette, M. (1); Bakshi, M (1); Verberne, EA (1); Rafael-Croes, L (1); show less...

University: Uppsala University (1); Luleå University of Technology (1); Karolinska Institutet (1)

Language: English (3)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

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