| 1. |
- Menkveld, Albert J., et al.
(författare)
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Nonstandard Errors
- 2024
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Ingår i: JOURNAL OF FINANCE. - : Wiley-Blackwell. - 0022-1082 .- 1540-6261. ; 79:3, s. 2339-2390
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Tidskriftsartikel (refereegranskat)abstract
- In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty-nonstandard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for more reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants.
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| 2. |
- Chirico, Francesco, et al.
(författare)
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Entrepreneurial Orientation, Generational Involvement and Participative Strategy: A Configurational Approach to Performance in Family Firms
- 2011
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Ingår i: Academy of Management 2011 Annual Meeting. - New York : Academy of Management.
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Konferensbidrag (refereegranskat)abstract
- To better understand the entrepreneurship in family firms, we consider the joint interaction effect of entrepreneurial orientation (EO), generational involvement and participative strategy. Drawing on the logic of resource orchestration, we argue that participative strategy acts as a coordinating mechanism that not only mitigates the relational conflict that increased generational involvement generates when mobilized EO, but also enhances family firms' ability to utilize the heterogeneous, yet complementary knowledge and experiences generational involvement offers. Configuring participative strategy and EO with generational involvement provides the direction and coordination needed to unlock the potential value of these unique resources. Our theory suggests that realizing the benefits from entrepreneurship in family firms is a complicated matter, affected by the configuration of EO, generational involvement and participative strategy.
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| 3. |
- Chirico, Francesco, et al.
(författare)
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Resource orchestration in family firms : Investigating how entrepreneurial orientation, generational involvement, and participative strategy affect performance
- 2011
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Ingår i: Strategic Entrepreneurship Journal. - : John Wiley & Sons. - 1932-4391 .- 1932-443X. ; 5:4, s. 307-326
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Tidskriftsartikel (refereegranskat)abstract
- Drawing on the process of resource orchestration, we argue a co-alignment of multiple factors is needed for family firms to increase performance through entrepreneurship. Specifically, we posit that entrepreneurial orientation provides the mobilizing vision to use the heterogeneous yet complementary knowledge and experiences offered by increased generational involvement toward entrepreneurship. However, without a coordinating mechanism, generational involvement leads to conflict and negative outcomes. When, instead, it is also coordinated via a participative strategy, performance gains are achieved. In sum, results suggest that realizing the benefits from entrepreneurship in family firms is a complicated matter affected by the synchronization of entrepreneurial orientation, generational involvement, and participative strategy. Copyright © 2011 Strategic Management Society.
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| 4. |
- Henein, Michael Y., et al.
(författare)
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Biomarkers predict in-hospital major adverse cardiac events in covid-19 patients : A multicenter international study
- 2021
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Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 10:24
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Tidskriftsartikel (refereegranskat)abstract
- Background: The COVID-19 pandemic carries a high burden of morbidity and mortality worldwide. We aimed to identify possible predictors of in-hospital major cardiovascular (CV) events in COVID-19.Methods: We retrospectively included patients hospitalized for COVID-19 from 10 centers. Clinical, biochemical, electrocardiographic, and imaging data at admission and medications were collected. Primary endpoint was a composite of in-hospital CV death, acute heart failure (AHF), acute myocarditis, arrhythmias, acute coronary syndromes (ACS), cardiocirculatory arrest, and pulmonary embolism (PE).Results: Of the 748 patients included, 141(19%) reached the set endpoint: 49 (7%) CV death, 15 (2%) acute myocarditis, 32 (4%) sustained-supraventricular or ventricular arrhythmias, 14 (2%) cardiocirculatory arrest, 8 (1%) ACS, 41 (5%) AHF, and 39 (5%) PE. Patients with CV events had higher age, body temperature, creatinine, high-sensitivity troponin, white blood cells, and platelet counts at admission and were more likely to have systemic hypertension, renal failure (creatinine ≥ 1.25 mg/dL), chronic obstructive pulmonary disease, atrial fibrillation, and cardiomyopathy. On univariate and multivariate analysis, troponin and renal failure were associated with the composite endpoint. Kaplan–Meier analysis showed a clear divergence of in-hospital composite event-free survival stratified according to median troponin value and the presence of renal failure (Log rank p < 0.001).Conclusions: Our findings, derived from a multicenter data collection study, suggest the routine use of biomarkers, such as cardiac troponin and serum creatinine, for in-hospital prediction of CV events in patients with COVID-19.
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| 5. |
- Lazzaroni, Francesca, et al.
(författare)
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Circulating biomarkers in familial cerebral cavernous malformation
- 2024
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Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 99
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Tidskriftsartikel (refereegranskat)abstract
- Background Cerebral Cavernous Malformation (CCM) is a rare cerebrovascular disease, characterized by the presence of multiple vascular malformations that may result in intracerebral hemorrhages (ICHs), seizure(s), or focal neurological deficits (FND). Familial CCM (fCCM) is due to loss of function mutations in one of the three independent genes KRIT1 (CCM1), Malcavernin (CCM2), or Programmed Cell death 10 (PDCD10/CCM3). The aim of this study was to identify plasma protein biomarkers of fCCM to assess the severity of the disease and predict its progression.Methods Here, we have investigated plasma samples derived from n = 71 symptomatic fCCM patients (40 female/31 male) and n =17 healthy donors (HD) (9 female/8 male) of the Phase 1/2 Treat_CCM trial, using multiplexed protein profiling approaches.Findings Biomarkers as sCD14 (p = 0.00409), LBP (p = 0.02911), CXCL4 (p = 0.038), ICAM-1 (p = 0.02013), ANG2 (p = 0.026), CCL5 (p = 0.00403), THBS1 (p = 0.0043), CRP (p = 0.0092), and HDL (p = 0.027), were significantly different in fCCM compared to HDs. Of note, sENG (p = 0.011), THBS1 (p = 0.011) and CXCL4 (p = 0.011), were correlated to CCM genotype. sROBO4 (p = 0.014), TM (p = 0.026) and CRP (p = 0.040) were able to predict incident adverse clinical events, such as ICH, FND or seizure. GDF-15, FLT3L, CXCL9, FGF-21 and CDCP1, were identified as predictors of the formation of new MRI-detectable lesions over 2-year follow-up. Furthermore, the functional relevance of ang2, thbs1, robo4 and cdcp1 markers was validated by zebrafish pre-clinical model of fCCM.Interpretation Overall, our study identifies a set of biochemical parameters to predict CCM progression, suggesting biological interpretations and potential therapeutic approaches to CCM disease.
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| 6. |
- Mazzola, Pietro, et al.
(författare)
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Non-linear effects of family management on entrepreneurial orientation in family-owned firms
- 2010
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Ingår i: Frontiers of Entrepreneurship Research.
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Konferensbidrag (refereegranskat)abstract
- Only a few studies explore the effects of family management (FM) on entrepreneurial orientation (EO) and hold conflicting positions. Thus, we attempt to shed some light on how FM impacts on EO. Past empirical studies tend to overlook the multifaceted nature of the concept of FM. For this reason, we conceive FM not only as the number of generations involved in the management of the firm (NGI) but also as the percentage of managers who are family members (PMFM). We contend that the benefits of NGI, captured in previous literature by the stewardship theory, should be coupled with the costs of involving several generations, introduced by the so-called stagnation perspective. These costs are related to the ownership-management overlap, the possibility of conflicts and the lack of resources that usually characterizes new generations. Moreover, we argue that PMFM induce negative effects similar to the above-mentioned ones, without the benefits that instead NGI brings. Thus, we develop and test a hypothesis on an inverted U-shaped relationship between NGI and EO, and a hypothesis on a negative relationship between PMFM and EO.
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| 7. |
- Sciascia, Salvatore, et al.
(författare)
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Entrepreneurial orientation and performance in family-owned firms: the role of family management
- 2010
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Ingår i: Frontiers of Entrepreneurship Research.
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Konferensbidrag (refereegranskat)abstract
- Many moderators of the EO-P relationship have been previously identified, but research on management-related factors conducive to EO effectiveness remains insufficient. In particular, no scholar asked whether the effectiveness of EO is facilitated or hampered by a family management (FM). FM can be referred both to the percentage of managers who are family members (PMFM) and to the number of generations involved in management (NGI). In this research we seek to explore how PMFM and NGI influence the EO-P relationship. Drawing on the agency (Jensen and Meckling, 1976; Schulze et al., 2001) and the upper echelon theories (Hambrick & Mason, 1984), we theorize and empirically test that the more a family is involved in the management of the firm, the lower EO effectiveness. In other words, we test that both PMFM and NGI play the role of negative moderators of the EO-P relationship.
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| 8. |
- Sciascia, Salvatore, et al.
(författare)
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Generational involvement in the top management team of family firms: Exploring nonlinear effects on entrepreneurial orientation
- 2013
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Ingår i: Entrepreneurship. - : SAGE Publications. - 1042-2587 .- 1540-6520. ; 37:1, s. 69-85
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Tidskriftsartikel (refereegranskat)abstract
- The present study contends that an inverted U-shaped relationship exists between generational involvement –i.e. the number of family generations simultaneously involved in the family firm top management team (TMT) – and corporate entrepreneurship (CE). Drawing on the upper echelons theory, we conceive generational involvement as a proxy of knowledge diversity in multigenerational family TMTs. We argue that while moderate levels of generational involvement stimulate task-related constructive conflicts for CE, increased kinship distance and relationship conflicts led by high levels of generational involvement are likely to undermine this potential advantage by damaging the relational context for CE.
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