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1.	Khudiakov, AA, et al. (author) Different Expressions of Pericardial Fluid MicroRNAs in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy and Ischemic Heart Disease Undergoing Ventricular Tachycardia Ablation 2021 In: Frontiers in cardiovascular medicine. - : Frontiers Media SA. - 2297-055X. ; 8, s. 647812- Journal article (peer-reviewed)abstract Introduction: Pericardial fluid is enriched with biologically active molecules of cardiovascular origin including microRNAs. Investigation of the disease-specific extracellular microRNAs could shed light on the molecular processes underlying disease development. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart disease characterized by life-threatening arrhythmias and progressive heart failure development. The current data about the association between microRNAs and ARVC development are limited.Methods and Results: We performed small RNA sequence analysis of microRNAs of pericardial fluid samples obtained during transcutaneous epicardial access for ventricular tachycardia (VT) ablation of six patients with definite ARVC and three post-infarction VT patients. Disease-associated microRNAs of pericardial fluid were identified. Five microRNAs (hsa-miR-1-3p, hsa-miR-21-5p, hsa-miR-122-5p, hsa-miR-206, and hsa-miR-3679-5p) were found to be differentially expressed between patients with ARVC and patients with post-infarction VT. Enrichment analysis of differentially expressed microRNAs revealed their close linkage to cardiac diseases.Conclusion: Our data extend the knowledge of pericardial fluid microRNA composition and highlight five pericardial fluid microRNAs potentially linked to ARVC pathogenesis. Further studies are required to confirm the use of pericardial fluid RNA sequencing in differential diagnosis of ARVC.
2.	Korkosh, VS, et al. (author) Atomic Mechanisms of Timothy Syndrome-Associated Mutations in Calcium Channel Cav1.2 2019 In: Frontiers in physiology. - : Frontiers Media SA. - 1664-042X. ; 10, s. 335- Journal article (peer-reviewed)
3.	Korkosh, VS, et al. (author) Timothy Syndrome-Associated Mutations Affect State-Dependent Contacts in L-Type Calcium Channel 2019 In: BIOPHYSICAL JOURNAL. - : Elsevier BV. - 0006-3495. ; 116:3, s. 312A-312A Conference paper (other academic/artistic)
4.	Lyasnikova, E, et al. (author) Molecular effects of cardiac contractility modulation in patients with heart failure of ischemic aetiology uncovered by transcriptome analysis 2024 In: Frontiers in cardiovascular medicine. - 2297-055X. ; 11, s. 1321005- Journal article (peer-reviewed)
5.	Zaytseva, AK, et al. (author) Characterization of a novel SCN5A genetic variant A1294G associated with mixed clinical phenotype 2019 In: Biochemical and biophysical research communications. - : Elsevier BV. - 1090-2104 .- 0006-291X. ; 516:3, s. 777-783 Journal article (peer-reviewed)

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Type of publication: journal article (4); conference paper (1)

Type of content: peer-reviewed (4); other academic/artistic (1)

Author/Editor: Mikhaylov, EN (5); Kostareva, AA (4); Lebedev, DS (3); Zhorov, BS (3); Korkosh, VS (2); Kiselev, AM (2); show more...; Kostareva, A (1); Faggian, G (1); Sergushichev, A. (1); Khudiakov, AA (1); Panshin, DD (1); Fomicheva, YV (1); Knyazeva, AA (1); Simonova, KA (1); Mitrofanova, L (1); Sukhareva, K (1); Zaytseva, AK (1); Kisilev, AM (1); Lyasnikova, E (1); Vander, M (1); Zaitsev, K (1); Firulyova, M (1); Sorokina, M (1); Trukshina, M (1); Galenko, V (1); Lelyavina, T (1); Simonova, K (1); Abramov, M (1); Luciani, GB (1); Sitnikova, M (1); Karpushev, AV (1); show less...

University: Karolinska Institutet (5)

Language: English (5)

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