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1.	Milon, B, et al. (author) A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma 2021 In: Cell reports. - : Elsevier BV. - 2211-1247. ; 36:13, s. 109758- Journal article (peer-reviewed)
2.	Fontaine, C., et al. (author) The tissue-specific effects of different 17 beta-estradiol doses reveal the key sensitizing role of AF1 domain in ER alpha activity 2020 In: Molecular and Cellular Endocrinology. - : Elsevier BV. - 0303-7207. ; 505 Journal article (peer-reviewed)abstract 17 beta-Estradiol (E2) action can be mediated by the full-length estrogen receptor alpha (ER alpha 66), and also by the AF1 domain-deficient ER alpha (ER alpha 46) isoform, but their respective sensitivity to E2 is essentially unknown. We first performed a dose response study using subcutaneous home-made pellets mimicking either metestrus, proestrus or a pharmacological doses of E2, which resulted in plasma concentrations around 3, 30 and 600 pM, respectively. Analysis of the uterus, vagina and bone after chronic exposure to E2 demonstrated dose-dependent effects, with a maximal response reached at the proestrus-dose in wild type mice expressing mainly ER alpha 66. In contrast, in transgenic mice harbouring only an ER alpha deleted in AF1, these effects of E2 were either strongly shifted rightward (10-100-fold) and/or attenuated, depending on the tissue studied. Finally, experiments in different cell lines transfected with ER alpha 66 or ER alpha 46 also delineated varying profiles of ER alpha AF1 sensitivity to E2. Altogether, this work emphasizes the importance of dose in the tissue-specific actions of E2 and demonstrates the key sensitizing role of AF1 in ER alpha activity.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Kim, S. H. (1); Song, Y. (1); Cederroth, CR (1); Mitra, S. (1); Buscato, M. (1); Raymond-Letron, I. (1); show more...; Gourdy, P. (1); Ohlsson, Claes, 1965 (1); Fontaine, C. (1); Arnal, J. F. (1); Lenfant, F. (1); Canlon, B (1); Katzenellenbogen, J. ... (1); Orvis, J (1); Hertzano, R (1); Sarlus, H (1); Burns, J (1); Vinel, A. (1); Giton, F. (1); Katzenellenbogen, B. ... (1); Milon, A. (1); Flouriot, G. (1); Ogawa, Y (1); Elkon, R (1); Milon, B (1); Shulman, ED (1); So, KS (1); Lipford, EL (1); Sperber, M (1); Sellon, JB (1); Pregernig, G (1); Shuster, B (1); Margulies, Z (1); Shults, C (1); Depireux, DA (1); Palermo, AT (1); show less...

University: University of Gothenburg (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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