SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Montenegro Burke J. Rafael) "

Search: WFRF:(Montenegro Burke J. Rafael)

  • Result 1-2 of 2
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Cintron-Colon, Rigo, et al. (author)
  • Activation of Kappa Opioid Receptor Regulates the Hypothermic Response to Calorie Restriction and Limits Body Weight Loss
  • 2019
  • In: Current Biology. - : Elsevier BV. - 0960-9822 .- 1879-0445. ; 29:24, s. 4291-4299
  • Journal article (peer-reviewed)abstract
    • Mammals maintain a nearly constant core body temperature (T-b) by balancing heat production and heat dissipation. This comes at a high metabolic cost that is sustainable if adequate calorie intake is maintained. When nutrients are scarce or experimentally reduced such as during calorie restriction (CR), endotherms can reduce energy expenditure by lowering T-b [1-6]. This adaptive response conserves energy, limiting the loss of body weight due to low calorie intake [710]. Here we show that this response is regulated by the kappa opioid receptor (KOR). CR is associated with increased hypothalamic levels of the endogenous opioid Leuenkephalin, which is derived from the KOR agonist precursor dynorphin [11]. Pharmacological inhibition of KOR, but not of the delta or the mu opioid receptor subtypes, fully blocked CR-induced hypothermia and increased weight loss during CR independent of calorie intake. Similar results were seen with DIO mice subjected to CR. In contrast, inhibiting KOR did not change T-b in animals fed ad libitum (AL). Chemogenetic inhibition of KOR neurons in the hypothalamic preoptic area reduced the CR-induced hypothermia, whereas chemogenetic activation of prodynorphin-expressing neurons in the arcuate or the parabrachial nucleus lowered T-b. These data indicate that KOR signaling is a pivotal regulator of energy homeostasis and can affect body weight during dieting by modulating T-b and energy expenditure.
  •  
2.
  • Domingo-Almenara, Xavier, et al. (author)
  • CMS-MRM and METLIN-MRM : a cloud library and public resource for targeted analysis of small molecules
  • 2018
  • In: Nature Methods. - : Nature Publishing Group. - 1548-7091 .- 1548-7105. ; 15:9, s. 681-
  • Journal article (peer-reviewed)abstract
    • We report XCMS-MRM and METLIN-MRM (http://xcmsonline-mrm.scripps.edu/ and http://metlin.scripps.edu/), a cloud-based data-analysis platform and a public multiple-reaction monitoring (MRM) transition repository for small-molecule quantitative tandem mass spectrometry. This platform provides MRM transitions for more than 15,500 molecules and facilitates data sharing across different instruments and laboratories.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-2 of 2

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view