| 1. |
- Aakash, förnamn, et al.
(författare)
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Structural, magnetic and hyperfine characterizations of nanocrystalline Zn-Cd doped nickel ferrites
- 2017
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Ingår i: Journal of Magnetism and Magnetic Materials. - : ELSEVIER SCIENCE BV. - 0304-8853 .- 1873-4766. ; 441, s. 710-717
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Tidskriftsartikel (refereegranskat)abstract
- In our present work, we have synthesized a series of Cd-Zn doped nickel ferrite ((Cd-0.5 Zn-x(x)) Ni0(.5)Fe(2)O(4); x = 0, 0.1, 0.2, 0.3, 0.4 and 0.5) through standard chemical co-precipitation method to study the influence of diamagnetic ions (Cd, Zn) on the magnetic properties of ferrites. XRD and Raman spectroscopy were employed for the structural characterizations. The refinement of the X-ray diffractogram data augmented by the Williamson-Hall plots showed the presence of Cd2+ vacancies and a strained crystal structure. The vibrational spectroscopy indicated the presence of lower space-group symmetry and a distorted crystal structure. Magnetic measurements showed the samples possessed low magnetic anisotropy along with a canted spin structure. The Mossbauer measurements confirmed the cation distribution and gave evidence of super transferred hyperfine interactions arising due to canted spin structure of the system.
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| 2. |
- Mukherjee, Saikat, et al.
(författare)
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Administration of soluble gp130Fc disrupts M-1 macrophage polarization, dendritic cell activation, MDSC expansion and Th-17 induction during experimental cerebral malaria
- 2023
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Ingår i: International Immunopharmacology. - : ELSEVIER. - 1567-5769 .- 1878-1705. ; 123
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Tidskriftsartikel (refereegranskat)abstract
- Regulatory effect of IL-6 on various immune cells plays a crucial role during experimental cerebral malaria pathogenesis. IL-6 neutralization can restore distorted ratios of myeloid dendritic cells and plasmacytoid dendritic cells as well as the balance between Th-17 and T-regulatory cells. IL-6 can also influence immune cells through classical and trans IL-6 signalling pathways. As trans IL-6 signalling is reportedly involved during malaria pathogenesis, we focused on studying the effects of trans IL-6 signalling blockade on various immune cell populations and how they regulate ECM progression. Results show that administration of sgp130Fc recombinant chimera protein lowers the parasitemia, increases the survivability of Plasmodium berghei ANKA infected mice, and restores the distorted ratios of M1/M2 macrophage, mDC/pDC, and Th-17/Treg. IL-6 trans signalling blockade has been found to affect both expansion of myeloid derived suppressor cells (MDSCs) and expression of inflammatory markers on them during Plasmodium berghei ANKA infection indicating that trans IL-6 signalling might regulate various immune cells and their function during ECM. In this work for the first time, we delineate the effect of sgp130Fc administration on influencing the immunological changes within the host secondary lymphoid organ during ECM induced by Plasmodium berghei ANKA infection.
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| 3. |
- Mukherjee, Saikat, et al.
(författare)
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IL-6 dependent expansion of inflammatory MDSCs (CD11b+ Gr-1+) promote Th-17 mediated immune response during experimental cerebral malaria
- 2022
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Ingår i: Cytokine. - London, United Kingdom : Academic Press. - 1043-4666 .- 1096-0023. ; 155, s. 155910-155910
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Tidskriftsartikel (refereegranskat)abstract
- Myeloid derived suppressor cells (MDSCs) are a group of heterogeneous cell populations that can suppress T cell responses. Various aspects of MDSCs in regulating immune responses in several cancer and infectious diseases have been reported till date. But the role and regulation of MDSCs have not been systematically studied in the context of malaria. This study depicts the phenotypic and functional characteristics of splenic MDSCs and how they regulate Th-17 mediated immune response during Experimental Cerebral Malaria (ECM). Flow cytometric analysis reveals that MDSCs in the spleen and bone marrow expand at 8 dpi during ECM. Among subtypes of MDSCs, PMN-MDSCs show significant expansion in the spleen but M-MDSCs remain unaltered. Functional analysis of sorted MDSCs from spleens of Plasmodium berghei ANKA (PbA) infected mice shows suppressive nature of these cells and high production of Nitric oxide (NO). Besides, MDSCs were also found to express various inflammatory markers during ECM suggesting the M1 type phenotype of these cells. In-vivo depletion of MDSCs by the use of Anti Gr-1 increases mice survival but doesn’t significantly alter the parasitemia. Previously, it has been reported that Treg/Th-17 balance in the spleen is skewed towards Th-17 during ECM. Depletion of MDSCs was found to regulate Th-17 percentages to homeostatic levels and subvert various inflammatory changes in the spleen. Among different factors, IL-6 was found to play an important role in the expansion of MDSCs and expression of inflammatory markers on MDSCs in a STAT3-dependent manner. These findings provide a unique insight into the role of IL-6 in the expansion of the MDSC population which causes inflammatory changes and increased Th-17 responses during ECM.
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