| 1. |
- Abel, I, et al.
(författare)
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Overview of the JET results with the ITER-like wall
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10, s. 104002-
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Tidskriftsartikel (refereegranskat)abstract
- Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Z(eff) (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. The re-establishment of the baseline H-mode and hybrid scenarios compatible with the new wall has required an optimization of the control of metallic impurity sources and heat loads. Stable type-I ELMy H-mode regimes with H-98,H-y2 close to 1 and beta(N) similar to 1.6 have been achieved using gas injection. ELM frequency is a key factor for the control of the metallic impurity accumulation. Pedestal temperatures tend to be lower with the new wall, leading to reduced confinement, but nitrogen seeding restores high pedestal temperatures and confinement. Compared with the carbon wall, major disruptions with the new wall show a lower radiated power and a slower current quench. The higher heat loads on Be wall plasma-facing components due to lower radiation made the routine use of massive gas injection for disruption mitigation essential.
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| 2. |
- Agirre, Jon, et al.
(författare)
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The CCP4 suite: integrative software for macromolecular crystallography
- 2023
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Ingår i: Acta Crystallographica Section D. - : INT UNION CRYSTALLOGRAPHY. - 2059-7983. ; 79, s. 449-461
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Tidskriftsartikel (refereegranskat)abstract
- The Collaborative Computational Project No. 4 (CCP4) is a UK-led international collective with a mission to develop, test, distribute and promote software for macromolecular crystallography. The CCP4 suite is a multiplatform collection of programs brought together by familiar execution routines, a set of common libraries and graphical interfaces. The CCP4 suite has experienced several considerable changes since its last reference article, involving new infrastructure, original programs and graphical interfaces. This article, which is intended as a general literature citation for the use of the CCP4 software suite in structure determination, will guide the reader through such transformations, offering a general overview of the new features and outlining future developments. As such, it aims to highlight the individual programs that comprise the suite and to provide the latest references to them for perusal by crystallographers around the world.
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| 3. |
- Mikkelsen, Tarjei S, et al.
(författare)
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Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7141, s. 167-177
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Tidskriftsartikel (refereegranskat)abstract
- We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive features of the opossum chromosomes provide support for recent theories about genome evolution and function, including a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation. Comparison of opossum and eutherian genomes also reveals a sharp difference in evolutionary innovation between protein-coding and non-coding functional elements. True innovation in protein-coding genes seems to be relatively rare, with lineage-specific differences being largely due to diversification and rapid turnover in gene families involved in environmental interactions. In contrast, about 20% of eutherian conserved non-coding elements (CNEs) are recent inventions that postdate the divergence of Eutheria and Metatheria. A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation.
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| 4. |
- Patterson, Nick, et al.
(författare)
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Large-scale migration into Britain during the Middle to Late Bronze Age
- 2022
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; , s. 588-594
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Tidskriftsartikel (refereegranskat)abstract
- Present-day people from England and Wales harbour more ancestry derived from Early European Farmers (EEF) than people of the Early Bronze Age1. To understand this, we generated genome-wide data from 793 individuals, increasing data from the Middle to Late Bronze and Iron Age in Britain by 12-fold, and Western and Central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of Iron Age people of England and Wales, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange2-6. There was comparatively less gene flow from continental Europe during the Iron Age, and Britain's independent genetic trajectory is also reflected in the rise of the allele conferring lactase persistence to ~50% by this time compared to ~7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period.
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| 5. |
- Brown, Sally, et al.
(författare)
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Shifting perspectives on coastal impacts and adaptation
- 2014
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Ingår i: Nature Climate Change. - : Nature Publishing Group. - 1758-678X .- 1758-6798. ; 4:9, s. 752-755
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The Intergovernmental Panel on Climate Change reports reflect evolving attitudes in adapting to sea-level rise by taking a systems approach and recognizing that multiple responses exist to achieve a less hazardous coast.
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| 6. |
- Hinkel, Jochen, et al.
(författare)
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A global analysis of erosion of sandy beaches and sea-level rise: An application of DIVA
- 2013
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Ingår i: Global and Planetary Change. - : Elsevier. - 0921-8181 .- 1872-6364. ; 111, s. 150-158
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a first assessment of the global effects of climate-induced sea-level rise on the erosion of sandy beaches, and its consequent impacts in the form of land loss and forced migration of people. We consider direct erosion on open sandy coasts and indirect erosion near selected tidal inlets and estuaries, using six global mean sea-level scenarios (in the range of 0.2-0.8 m) and six SRES socio-economic development scenarios for the 21st century. Impacts are assessed both without and with adaptation in the form of shore and beach nourishment, based on cost-benefit analysis that includes the benefits of maintaining sandy beaches for tourism. Without nourishment, global land loss would amount to about 6000-17,000 km(2) during the 21st century, leading to 1.6-5.3 million people being forced to migrate and migration costs of US$ 300-1000 billion (not discounted). Optimal beach and shore nourishment would cost about US$ 65-220 billion (not discounted) during the 21st century and would reduce land loss by 8-14%, forced migration by 56-68% and the cost of forced migration by 77-84% (not discounted). The global share of erodible coast that is nourished increases from about 4% in 2000 to 18-33% in 2100, with beach nourishment being 3-4 times more frequent than shore nourishment, reflecting the importance of tourism benefits. In absolute terms, with or without nourishment, large counties with long shorelines appear to have the largest costs, but in relative terms, small island states appear most impacted by erosion. Considerable uncertainty remains due to the limited availability of basic coastal geomorphological data and models on a global scale. Future work should also further explore the effects of beach tourism, including considering sub-national distributions of beach tourists.
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| 7. |
- Hinkel, Jochen, et al.
(författare)
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The effects of adaptation and mitigation on coastal flood impacts during the 21st century. An application of the DIVA and IMAGE models
- 2013
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Ingår i: Climatic Change. - : Springer Verlag (Germany). - 0165-0009 .- 1573-1480. ; 117:4, s. 783-794
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Tidskriftsartikel (refereegranskat)abstract
- This paper studies the effects of mitigation and adaptation on coastal flood impacts. We focus on a scenario that stabilizes concentrations at 450 ppm-CO2-eq leading to 42 cm of global mean sea-level rise in 1995-2100 (GMSLR) and an unmitigated one leading to 63 cm of GMSLR. We also consider sensitivity scenarios reflecting increased tropical cyclone activity and a GMSLR of 126 cm. The only adaptation considered is upgrading and maintaining dikes. Under the unmitigated scenario and without adaptation, the number of people flooded reaches 168 million per year in 2100. Mitigation reduces this number by factor 1.4, adaptation by factor 461 and both options together by factor 540. The global annual flood cost (including dike upgrade cost, maintenance cost and residual damage cost) reaches US$ 210 billion per year in 2100 under the unmitigated scenario without adaptation. Mitigation reduces this number by factor 1.3, adaptation by factor 5.2 and both options together by factor 7.8. When assuming adaptation, the global annual flood cost relative to GDP falls throughout the century from about 0.06 % to 0.01-0.03 % under all scenarios including the sensitivity ones. From this perspective, adaptation to coastal flood impacts is meaningful to be widely applied irrespective of the level of mitigation. From the perspective of a some less-wealthy and small island countries, however, annual flood cost can amount to several percent of national GDP and mitigation can lower these costs significantly. We conclude that adaptation and mitigation are complimentary policies in coastal areas.
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| 8. |
- Marcinko, Charlotte L. J., et al.
(författare)
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The Development of a Framework for the Integrated Assessment of SDG Trade-Offs in the Sundarban Biosphere Reserve
- 2021
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Ingår i: Water. - : MDPI AG. - 2073-4441. ; 13:4
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Tidskriftsartikel (refereegranskat)abstract
- The United Nations Sustainable Development Goals (SDGs) and their corresponding targets are significantly interconnected, with many interactions, synergies, and trade-offs between individual goals across multiple temporal and spatial scales. This paper proposes a framework for the Integrated Assessment Modelling (IAM) of a complex deltaic socio-ecological system in order to analyze such SDG interactions. We focused on the Sundarban Biosphere Reserve (SBR), India, within the Ganges-Brahmaputra-Meghna Delta. It is densely populated with 4.4 million people (2011), high levels of poverty, and a strong dependence on rural livelihoods. It is adjacent to the growing megacity of Kolkata. The area also includes the Indian portion of the world’s largest mangrove forest––the Sundarbans––hosting the iconic Bengal Tiger. Like all deltaic systems, this area is subject to multiple drivers of environmental change operating across scales. The IAM framework is designed to investigate socio-environmental change under a range of explorative and/or normative scenarios and explore associated policy impacts, considering a broad range of subthematic SDG indicators. The following elements were explicitly considered: (1) agriculture; (2) aquaculture; (3) mangroves; (4) fisheries; and (5) multidimensional poverty. Key questions that can be addressed include the implications of changing monsoon patterns, trade-offs between agriculture and aquaculture, or the future of the Sundarbans’ mangroves under sea-level rise and different management strategies. The novel, high-resolution analysis of SDG interactions allowed by the IAM will provide stakeholders and policy makers the opportunity to prioritize and explore the SDG targets that are most relevant to the SBR and provide a foundation for further integrated analysis.
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| 9. |
- Treasure, Anne M., et al.
(författare)
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Marine Mammals Exploring the Oceans Pole to Pole A Review of the MEOP Consortium
- 2017
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Ingår i: Oceanography. - : The Oceanography Society. - 1042-8275. ; 30:2, s. 132-138
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Tidskriftsartikel (refereegranskat)abstract
- Polar oceans are poorly monitored despite the important role they play in regulating Earth's climate system. Marine mammals equipped with biologging devices are now being used to fill the data gaps in these logistically difficult to sample regions. Since 2002, instrumented animals have been generating exceptionally large data sets of oceanographic CTD casts (>500,000 profiles), which are now freely available to the scientific community through the MEOP data portal (http://meop.net). MEOP (Marine Mammals Exploring the Oceans Pole to Pole) is a consortium of international researchers dedicated to sharing animal-derived data and knowledge about the polar oceans. Collectively, MEOP demonstrates the power and cost-effectiveness of using marine mammals as data-collection platforms that can dramatically improve the ocean observing system for biological and physical oceanographers. Here, we review the MEOP program and database to bring it to the attention of the international community.
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| 10. |
- Volz, Erik, et al.
(författare)
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Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
- 2021
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Ingår i: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 184:1, s. 11-75
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Tidskriftsartikel (refereegranskat)abstract
- Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant.
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