| 1. |
- Paulsson, Ulf, et al.
(författare)
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Flödesfokusering i en föränderlig värld
- 2000. - 1
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Ingår i: Flödesekonomi : Supply Chain Management - Supply Chain Management. - 9144007299 - 9789144007298 ; , s. 163-166
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Bokkapitel (populärvet., debatt m.m.)
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| 2. |
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| 3. |
- Paulsson, Ulf, et al.
(författare)
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Kundrelaterat flöde och kommunikation
- 2000. - 1
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Ingår i: Flödesekonomi : Supply Chain Management - Supply Chain Management. - 9144007299 - 9789144007298 ; , s. 44-56
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Bokkapitel (populärvet., debatt m.m.)
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| 4. |
- Rykaczewska, Urszula, et al.
(författare)
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PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling
- 2020
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Ingår i: Circulation Research. - : LIPPINCOTT WILLIAMS & WILKINS. - 0009-7330 .- 1524-4571. ; 126:5, s. 571-585
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: PCSKs (Proprotein convertase subtilisins/kexins) are a protease family with unknown functions in vasculature. Previously, we demonstrated PCSK6 upregulation in human atherosclerotic plaques associated with smooth muscle cells (SMCs), inflammation, extracellular matrix remodeling, and mitogens. Objective: Here, we applied a systems biology approach to gain deeper insights into the PCSK6 role in normal and diseased vessel wall. Methods and Results: Genetic analyses revealed association of intronic PCSK6 variant rs1531817 with maximum internal carotid intima-media thickness progression in high-cardiovascular risk subjects. This variant was linked with PCSK6 mRNA expression in healthy aortas and plaques but also with overall plaque SMA+ cell content and pericyte fraction. Increased PCSK6 expression was found in several independent human cohorts comparing atherosclerotic lesions versus healthy arteries, using transcriptomic and proteomic datasets. By immunohistochemistry, PCSK6 was localized to fibrous cap SMA+ cells and neovessels in plaques. In human, rat, and mouse intimal hyperplasia, PCSK6 was expressed by proliferating SMA+ cells and upregulated after 5 days in rat carotid balloon injury model, with positive correlation to PDGFB (platelet-derived growth factor subunit B) and MMP (matrix metalloprotease) 2/MMP14. Here, PCSK6 was shown to colocalize and cointeract with MMP2/MMP14 by in situ proximity ligation assay. Microarrays of carotid arteries from Pcsk6(-/-) versus control mice revealed suppression of contractile SMC markers, extracellular matrix remodeling enzymes, and cytokines/receptors. Pcsk6(-/-) mice showed reduced intimal hyperplasia response upon carotid ligation in vivo, accompanied by decreased MMP14 activation and impaired SMC outgrowth from aortic rings ex vivo. PCSK6 silencing in human SMCs in vitro leads to downregulation of contractile markers and increase in MMP2 expression. Conversely, PCSK6 overexpression increased PDGFBB (platelet-derived growth factor BB)-induced cell proliferation and particularly migration. Conclusions: PCSK6 is a novel protease that induces SMC migration in response to PDGFB, mechanistically via modulation of contractile markers and MMP14 activation. This study establishes PCSK6 as a key regulator of SMC function in vascular remodeling.
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| 5. |
- Agvall, Björn, et al.
(författare)
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Resource use and cost implications of implementing a heart failure program for patients with systolic heart failure in Swedish primary health care
- 2014
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Ingår i: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 176, s. 731-738
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Tidskriftsartikel (refereegranskat)abstract
- Aim: Heart failure (HF) is a common but serious condition which involves a significant economic burden on the health care economy. The purpose of this study was to evaluate cost and quality of life (QoL) implications of implementing a HF management program (HFMP) in primary health care (PHC).Methods and results: This was a prospective randomized open-label study including 160 patientswith a diagnosis of HF from five PHC centers in south-eastern Sweden. Patients randomized to the intervention group received information about HF from HF nurses and from a validated computer-based awareness program. HF nurses and physicians followed the patients intensely in order to optimize HF treatment according to current guidelines. The patients in the control group were followed by their regular general practitioner (GP) and received standard treatment according to local management routines. No significant changes were observed in NYHA class and quality-adjusted life years (QALY), implying that functional class and QoL were preserved. However, costs for hospital care (HC) and PHC were reduced by EUR 2167, or 33%. The total cost was EUR 4471 in the intervention group and EUR 6638 in the control group.Conclusions: Introducing HFMP in Swedish PHC in patients with HF entails a significant reduction in resource utilization and costs, and maintains QoL. Based on these results, a broader implementation of HFMP in PHC may be recommended. However, results should be confirmed with extended follow-up to verify long-term effects.
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| 6. |
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| 7. |
- Björklund, Maria, et al.
(författare)
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Academic papers and theses - to write and present and to act as an opponent
- 2014
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Bok (populärvet., debatt m.m.)abstract
- An educational method that is becoming all the more common at colleges and universities is that of the seminar. In the seminar, students write academic papers and reports, present them, and act as opponents on each other’s work. The book covers all the sections that are normally included in the seminar. The learning environment of the seminar is based on a scientific way of thinking and on scientific methods. With its point of departure in this foundation, the book aims to provide easily accessible information and advice about the ways in which academic work can be organized and carried out. Furthermore, the book takes up issues regarding layout, presentation of one’s work, opposition, and cheating, as well as criteria used to assess academic papers and theses. The book is intended for use on first-cycle levels at university colleges and universities, and within other forms of post-secondary school education. There is also a Swedish version of the book with the title: Seminarieboken – att skriva, presentera och opponera.
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| 8. |
- Björklund, Maria, 1973-, et al.
(författare)
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Att opponera
- 2003
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Annan publikation (populärvet., debatt m.m.)abstract
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| 9. |
- Björklund, Maria, 1973-, et al.
(författare)
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Att presentera
- 2003
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Annan publikation (populärvet., debatt m.m.)abstract
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| 10. |
- Björklund, Maria, 1973-, et al.
(författare)
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Att skriva
- 2003
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
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