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- Liu, Rui, et al.
(författare)
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Associations of sleep timing and time in bed with dementia and cognitive decline among Chinese older adults : A cohort study
- 2022
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Ingår i: Journal of The American Geriatrics Society. - : Wiley. - 0002-8614 .- 1532-5415. ; 70:11, s. 3138-3151
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Tidskriftsartikel (refereegranskat)abstract
- Background: The longitudinal associations of sleep timing and time in bed (TIB) with dementia and cognitive decline in older adults are unclear.Methods: This population-based cohort study used data from 1982 participants who were aged >= 60 years, free of dementia, and living in rural communities in western Shandong, China. At the baseline (2014) and follow-up (2018) examinations, sleep parameters were assessed using standard questionnaires. Cognitive function was measured using the Mini-Mental State Examination (MMSE). Dementia was diagnosed following the DSM-IV criteria, and the NIA-AA criteria for Alzheimer disease (AD). Data were analyzed using restricted cubic splines, Cox proportional-hazards models, and general linear models.Results: During the mean follow-up of 3.7 years, dementia was diagnosed in 97 participants (68 with AD). Restricted cubic spline curves showed J-shaped associations of sleep duration, TIB, and rise time with dementia risk, and a reverse J-shaped association with mid-sleep time. When sleep parameters were categorized into tertiles, the multivariable-adjusted hazard ratio (HR) of incident dementia was 1.69 (95%CI 1.01-2.83) for baseline sleep duration >8 hours (vs. 7-8 h), 2.17 (1.22-3.87) for bedtime before 9 p.m. (vs. 10 p.m. or later), and 2.00 (1.23-3.24) for mid-sleep time before 1 a.m. (vs. 1-1.5 a.m.). Early bedtime and mid-sleep time were significantly associated with incident AD (HR range: 2.25-2.51; p < 0.05). Among individuals who were free of dementia at follow-up, baseline long TIB, early bedtime and mid-sleep time, early and late rise time, and prolonged TIB and advanced bedtime and mid-sleep time from baseline to follow-up were associated with a greater decline in MMSE score (p < 0.05). These associations with cognitive decline were statistically evident mainly among men or participants who were aged 60-74 years.Conclusions: Long TIB and early sleep timing are associated with an increased risk of dementia, and the associations with greater cognitive decline are evident only among older people aged 60-74 years and men.
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- Christensen, Kirsten E, et al.
(författare)
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A germanate built from 68126 cavity co-templated by a (H2O)16 water cluster and 2-methylpiperazine
- 2008
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Ingår i: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 47:41, s. 7868-7871
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Tidskriftsartikel (refereegranskat)abstract
- Totally tubular: A new tubular germanate is cotemplated by 2-methylpiperazine and an (H2O)16 cluster in a hydro(solvo)thermal synthesis. The germanate features a large, highly symmetric 68126 cavity (see picture; yellow sphere) built from 12 Ge7X19 (X=O, OH, F) clusters (GeX6 red, GeX5 yellow, GeX4 green).
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- Tang, Liqiu, et al.
(författare)
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A Stacking Faults-Containing Silicogermanate with 24-Ring Channels and Unbranched Zweier Silica Double Chains
- 2012
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Ingår i: Crystal Growth & Design. - : American Chemical Society (ACS). - 1528-7483 .- 1528-7505. ; 12:7, s. 3714-3719
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Tidskriftsartikel (refereegranskat)abstract
- A novel open-framework silicogermanate SU-JU-14 (Stockholm University-Jilin University-Number 14), vertical bar NH3CH2CH2NH3 vertical bar(3)[Ge6.40Si0.60O15(OH)](2)[Ge0.73Si3.27O8], was synthesized by using ethylenediamine as the structure-directing agent under solvothermal conditions. Single-crystal structure analysis reveals that the crystal structure of SU-JU-14 consists of extended 24-ring channels built from [(Ge,Si)(7)O12O6/2(OH)](3-) [(Ge,Si)(7)] clusters and unbranched zweier silica double chains [Ge0.73Si3.27O4O8/2]. Charge neutrality is achieved by diprotonated ethylenediamine guest molecules. The structure consists of stacking faults of layered arrays in two different configurations along the a-axis. SU-JU-14 was characterized by X-ray diffraction, X-ray energy dispersive spectroscopy, scanning electron microscopy, nuclear magnetic resonance, inductively coupled plasma, and thermogravimetric analyses. Crystallographic data: monoclinic, space group C2/c, and unit cell parameters: a = 35.625 (7) angstrom, b = 28.580 (6) angstrom, c = 10.403 (2) angstrom, and beta = 98.30 (3)degrees.
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