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- Clark, Andrew G., et al.
(author)
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Evolution of genes and genomes on the Drosophila phylogeny
- 2007
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
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Journal article (peer-reviewed)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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- Hewitt, Graeme, et al.
(author)
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Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
- 2021
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In: Molecular Cell. - : Cell Press. - 1097-2765 .- 1097-4164. ; 81:4, s. 767-783.e11
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Journal article (peer-reviewed)abstract
- Chromatin is a barrier to efficient DNA repair, as it hinders access and processing of certain DNA lesions. ALC1/CHD1L is a nucleosome-remodeling enzyme that responds to DNA damage, but its precise function in DNA repair remains unknown. Here we report that loss of ALC1 confers sensitivity to PARP inhibitors, methyl-methanesulfonate, and uracil misincorporation, which reflects the need to remodel nucleosomes following base excision by DNA glycosylases but prior to handover to APEX1. Using CRISPR screens, we establish that ALC1 loss is synthetic lethal with homologous recombination deficiency (HRD), which we attribute to chromosome instability caused by unrepaired DNA gaps at replication forks. In the absence of ALC1 or APEX1, incomplete processing of BER intermediates results in post-replicative DNA gaps and a critical dependence on HR for repair. Hence, targeting ALC1 alone or as a PARP inhibitor sensitizer could be employed to augment existing therapeutic strategies for HRD cancers.
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- Lyon, Phil, et al.
(author)
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Broadcasting cookery : BBC radio programmes in the 1920s and 1930s
- 2016
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In: International Journal of Consumer Studies. - : Wiley. - 1470-6423 .- 1470-6431. ; 40:3, s. 327-335
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Journal article (peer-reviewed)abstract
- The development of British radio broadcasting technology in the 1920s and 1930s and,equally importantly, the progressively widespread purchase and use of radio setsestablished a new platform from which to engage and influence the population on anumber of matters. The British Broadcasting Corporation’s public service principles ofprogrammes to inform, educate and entertain gave rise to various content experiments ata time when there were very few precedents. One such innovation was the cookery talk.This was broadcast live, accomplished without the possibility of practical demonstration,and constituted a new, and abstract, form of communication primarily designed forwomen in their own homes. In this, women were the earliest and most frequentcontributors, and their broadcast content differed from that provided by men. Byreference to archive material, this article examines the social context and the thinkingbehind those early years of radio cookery talks and documents the contributors who wereto establish this now-familiar genre of broadcasting.
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- Ross, Liz, et al.
(author)
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Consumer choice for hearing aids and listening devices : newspaper advertisements for UK private sector provision
- 2011
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In: International Journal of Consumer Studies. - : Blackwell Publishing Ltd. - 1470-6423 .- 1470-6431. ; 35:1, s. 95-103
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Journal article (peer-reviewed)abstract
- In the UK there can be several ways to access health care and this is true of hearing aid provision. Although there may appear to be a well-defined distinction between the National Health Service (NHS) and independent dispenser hearing aid provision, there have been many examples of overlap between the two and recent government policy initiatives mean that distinctions have become less clear. This article outlines the changing relationship between the two sectors and the problems that potential consumers face accessing information on private sector options for amplification devices. A 1-year sample of newspaper advertisements was content-analysed for clarity of information provided. The analysis highlighted a range of provision, from well-known hearing aid dispensers to the greyer areas of listening device retailers and intermediary services. Some advertisements were found to have been reported to the Advertising Standards Authority. Sufficiently misleading adverts may also infringe consumer protection legislation. The article concludes there is the possibility of consumer confusion about products and their potential for amelioration.
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- Ross, Liz, et al.
(author)
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Escaping a silent world: profound earing loss, cochlear implants and household interaction
- 2006
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In: International Journal of Consumer Studies. - : Wiley. - 1470-6431 .- 1470-6423.
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Journal article (peer-reviewed)abstract
- For some people with profound hearing loss, cochlear implants offer a way back to patterns of communication that most of us take for granted. Travel, shopping and work contexts are largely dependent on the ability to recognize and respond to speech. This study examined implant user and partner perspectives on problems and coping strategies. The aim was to map the experiences of adults and their hearing partners living with deafness; and the changes brought about by cochlear implant use.Information was gathered by means of recorded joint interviews in a semi-structured form with implant users and their partners. Interview themes including social isolation, employment difficulties and loss of confidence emerged as main difficulties prior to implantation. All participants were positive regarding the use of cochlear implants and, after implantation, benefits accrued in communication and social interaction. Provision of multidisciplinary support and consumer information for severe/profoundly hearing impaired adults was seen as problematic. Sample size – six couples – reflected the limited number of adult cochlear implant operations performed in Scotland. However, the results indicate their interactional experiences to be worthy of further investigation on a larger scale.
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| 8. |
- Ross, Liz, et al.
(author)
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Pills, potions and devices : treatments for hearing loss advertised in mid-nineteenth century British newspapers
- 2014
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In: Social history of medicine. - Oxford : Oxford University Press. - 0951-631X .- 1477-4666. ; 27:3, s. 530-556
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Journal article (peer-reviewed)abstract
- This article examines the ameliorative options facing people with hearing loss in mid-nineteenth-century Britain. As reflected in professional journals of the day, medical understanding of diseases and dysfunctions of the ear was limited, yet there was vigorous assertion and counter-claim as to the cause and treatment of problems. At the time, medicine was largely unregulated and quack practitioners were also able to promote their nostrums and services to a credulous the general public with little chance of a genuine cure for their hearing loss. Using the nineteenth-century British Library Newspapers Archive for 1850, 379 advertisements offering cures for deafness were identified and examined to illustrate the variety of nostrums and devices offered to the public. Individuals with hearing loss were easy prey when even qualified medical practitioners had little understanding of cause or treatment, and when scant legal protection protected them from fraudulent treatment claims or offered redress for their failure.
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- Squazzoni, Flaminio, et al.
(author)
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Unlock ways to share data on peer review
- 2020
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In: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 578:7796, s. 512-514
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Journal article (peer-reviewed)
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