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Sökning: WFRF:(Schiffrin M)

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1.
  • Schiffrin, M, et al. (författare)
  • Sex Dimorphism of Nonalcoholic Fatty Liver Disease (NAFLD) in Pparg-Null Mice
  • 2021
  • Ingår i: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 22:18
  • Tidskriftsartikel (refereegranskat)abstract
    • Men with nonalcoholic fatty liver disease (NAFLD) are more exposed to nonalcoholic steatohepatitis (NASH) and liver fibrosis than women. However, the underlying molecular mechanisms of NALFD sex dimorphism are unclear. We combined gene expression, histological and lipidomic analyses to systematically compare male and female liver steatosis. We characterized hepatosteatosis in three independent mouse models of NAFLD, ob/ob and lipodystrophic fat-specific (PpargFΔ/Δ) and whole-body PPARγ-null (PpargΔ/Δ) mice. We identified a clear sex dimorphism occurring only in PpargΔ/Δ mice, with females showing macro- and microvesicular hepatosteatosis throughout their entire life, while males had fewer lipid droplets starting from 20 weeks. This sex dimorphism in hepatosteatosis was lost in gonadectomized PpargΔ/Δ mice. Lipidomics revealed hepatic accumulation of short and highly saturated TGs in females, while TGs were enriched in long and unsaturated hydrocarbon chains in males. Strikingly, sex-biased genes were particularly perturbed in both sexes, affecting lipid metabolism, drug metabolism, inflammatory and cellular stress response pathways. Most importantly, we found that the expression of key sex-biased genes was severely affected in all the NAFLD models we tested. Thus, hepatosteatosis strongly affects hepatic sex-biased gene expression. With NAFLD increasing in prevalence, this emphasizes the urgent need to specifically address the consequences of this deregulation in humans.
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5.
  • Kuzume, A., et al. (författare)
  • Electrochemical reactivity in nanoscale domains: O-2 reduction on a fullerene modified gold surface
  • 2005
  • Ingår i: Physical Chemistry Chemical Physics. - : Royal Society of Chemistry (RSC). - 1463-9076 .- 1463-9084. ; 7:6, s. 1293-1299
  • Tidskriftsartikel (refereegranskat)abstract
    • Fullerene is strongly adsorbed on both single crystal and polycrystalline gold surfaces and its specific adsorption resulted in the formation of high coverage large hexagonal rafts with strong interactions between the adsorbed fullerene molecules and the Au substrate. The oxygen reduction reaction (ORR) was investigated on these surfaces to determine their influence on the reduction mechanism. Oxygen reduction did not take place on the fullerene overlayer but proceeded on the sub-nanometer sized exposed pockets of the underlying Au substrate. Reduction at these confined sites produces hydrogen peroxide selectively. This effect is ascribed to the blocking action, or so-called "third body effect'', of the adsorbed fullerene molecules, which do not display electrocatalytic properties for oxygen reduction.
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