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1.	Blay, J., et al. (author) Characterisation Of The Hepatic Safety Profile Of Trabectedin: Pooled Analysis Of 19 Phase II Clinical Trials (CTS) In 1132 Patients With Solid Tumours 2010 In: Annals of Oncology. - : Elsevier BV. - 1569-8041 .- 0923-7534. ; 21:Suppl. 8, s. 177-178 Conference paper (peer-reviewed)
2.	Georgiesh, T, et al. (author) Validation of a novel risk score to predict early and late recurrence in solitary fibrous tumour 2022 In: British journal of cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 127:10, s. 1793-1798 Journal article (peer-reviewed)
3.	Kohne, CH, et al. (author) Clinical determinants of survival in patients with 5-fluorouracil-based treatment for metastatic colorectal cancer: results of a multivariate analysis of 3825 patients 2002 In: Annals of oncology : official journal of the European Society for Medical Oncology. - : Elsevier BV. - 0923-7534. ; 13:2, s. 308-317 Journal article (peer-reviewed)
4.	Pulkka, OP, et al. (author) Anagrelide for Gastrointestinal Stromal Tumor 2019 In: Clinical cancer research : an official journal of the American Association for Cancer Research. - 1557-3265. ; 25:5, s. 1676-1687 Journal article (peer-reviewed)
5.	Isfort, I, et al. (author) SS18-SSX-Dependent YAP/TAZ Signaling in Synovial Sarcoma 2019 In: Clinical cancer research : an official journal of the American Association for Cancer Research. - 1557-3265. ; 25:12, s. 3718-3731 Journal article (peer-reviewed)
6.	Schoffski, P., et al. (author) Tyrosine kinase inhibition in renal cell carcinoma and gastrointestinal stromal tumours: case reports 2009 In: Annals Of Oncology. - : Elsevier BV. - 0923-7534. ; 20, s. 25-31 Conference paper (peer-reviewed)abstract Background: Sunitinib malate is approved multinationally for the treatment of metastatic renal cell carcinoma (mRCC) and advanced imatinib-refractory gastrointestinal stromal tumour (GIST). Greater exposure to sunitinib is associated with improved efficacy. Therefore, minimising the impact of adverse events (AEs) on patient quality of life is important to enable patients to achieve optimal exposure to sunitinib and maximum clinical benefit. Design: This report describes four patient cases in which sunitinib was utilised for the management of advanced malignancies: two cases describe mRCC patients who received first-line sunitinib and two cases describe the use of targeted therapies, including sunitinib, in patients with advanced GIST. Results: In all four cases, effective AE management enabled patients to receive long-term therapy with sunitinib and achieve sustained clinical benefit. The two mRCC cases show prolonged responses and manageable AEs with sunitinib. The two GIST cases demonstrate that patients with imatinib-refractory GIST with KIT exon 9 mutations, including elderly patients, can achieve sustained responses to sunitinib. Conclusions: These case studies support the long-term efficacy and safety of sunitinib in the management of mRCC and imatinib-refractory GIST and demonstrate how AE management can be used to optimise patient responses.

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Type of publication: journal article (4); conference paper (2)

Type of content: peer-reviewed (6)

Author/Editor: Schoffski, P. (6); Mpindi, JP (1); Kallioniemi, O (1); Larsson, O (1); Joensuu, H (1); Cervera, A. (1); show more...; Cunningham, D (1); Zhang, YF (1); Glimelius, B (1); Palmér, M (1); Haas, RL (1); Hartmann, W (1); Jones, RL (1); Judson, I (1); Wardelmann, E (1); Flodgren, Per (1); Lehtonen, R (1); Laaksonen, M (1); Jebsen, NL (1); Pignatti, F (1); Wennerberg, K (1); Sihto, H. (1); Haglund, F (1); Högberg, Thomas (1); Icay, K (1); Varjosalo, M (1); Hautaniemi, S (1); Tang, G (1); Scheithauer, W. (1); Isfort, I. (1); Trautmann, M. (1); Le Cesne, A. (1); Huang, P (1); Blay, J. (1); Sessa, C. (1); Paz-Ares, L. (1); Zintl, P. (1); Parekh, T. V. (1); Demetri, G. D. (1); Wils, J (1); Blijham, G (1); Rougier, P (1); Aggerholm-Pedersen, ... (1); Murumagi, A (1); Sciot, R (1); Spalek, M. (1); Bjerkehagen, B. (1); Hesla, AC (1); van de Sande, M. (1); Bovee, Jvmg (1); show less...

University: Karolinska Institutet (4); Lund University (2)

Language: English (6)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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