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- Evangelou, Evangelos, et al.
(author)
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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
- 2018
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:10, s. 1412-1425
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Journal article (peer-reviewed)abstract
- High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
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- Gaziano, Liam, et al.
(author)
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Mild-to-moderate kidney dysfunction and cardiovascular disease : Observational and mendelian randomization analyses
- 2022
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In: Circulation. - : Wolters Kluwer. - 0009-7322 .- 1524-4539. ; 146:20, s. 1507-1517
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Journal article (peer-reviewed)abstract
- BACKGROUND: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke.METHODS: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25 917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank.RESULTS: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values <60 or >105 mL·min-1·1.73 m-2, compared with those with eGFR between 60 and 105 mL·min-1·1.73 m-2. Mendelian randomization analyses for CHD showed an association among participants with eGFR <60 mL·min-1·1.73 m-2, with a 14% (95% CI, 3%-27%) higher CHD risk per 5 mL·min-1·1.73 m-2 lower genetically predicted eGFR, but not for those with eGFR >105 mL·min-1·1.73 m-2. Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin A1c, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD.CONCLUSIONS: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function.
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- Balogh, Péter, 1982-
(author)
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Perpetual borders : German-Polish cross-border contacts in the Szczecin area
- 2014
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Doctoral thesis (other academic/artistic)abstract
- Borderlands are often peripheral geographically, administratively, and economically. A particularly illustrative case is the Szczecin area at the border between Poland and Germany, where a large city on one side neighbours to a sparsely populated hinterland on the other. There is a number of similar cases throughout Europe, but studies on them point to a mixed level of linkages following the opening and removal of the physical border.At the project’s start there were few if any studies on the Szczecin area per se, which was here studied through various methods. On the one hand, different pre-EU enlargement plans and visions for the area’s development were compared with practices and realities of recent years. This shows that earlier imaginations on the development potentials have not quite materialised, although some of them were probably too optimistic and ambitious from the beginning. Some of the area’s potentials following EU-enlargement have been more successfully exploited than others, and disproportionately by actors coming from outside. On the other hand, cross-border contacts were studied in the discourses on and attitudes towards the other side among local and regional elites, and among local residents more generally. This revealed a polarised attitudinal landscape, not least when compared to country-wide opinion surveys in both Germany and Poland. This is in line with other studies showing that identities are particularly accentuated in border situations, where the Other is more frequently encountered.These results support recent investigations pointing to a continued relevance of the border even after the physical barriers are removed. At the same time, another contribution of this work to border studies is that the time and contingency of the importance of identities and of the border needs more attention. In the Szczecin area, awareness of national identities and of the boundary appeared to be particularly high just after changes in the border’s status occurred – i.e. in 1989–1991, and then around the years 2007–2010. But while its importance may be fluctuating over time, given the opportunities and resources the boundary provides it will always be maintained in some forms.
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- Wagner Tsoni, Ioanna
(author)
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Affective Borderscapes : Constructing, Enacting and Contesting Borders across the Southeastern Mediterranean
- 2019
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Doctoral thesis (other academic/artistic)abstract
- In the wake of a sociopolitically volatile era, which is increasingly characterized by the intensive and extensive proliferation of borders, the management of borders and migration are considered as predominantly rational and dispassionate processes. Their functions and filtering mechanisms, however, are increasingly underpinned by the instrumental top-down exertion of affective power and by the cultivation of emotional dispositions among political communities. At the same time, compliance to- or contestation of these forces also manifests ‘from below’ through transgressive patterns of human mobilities and mobilisations around borders, which are similarly affectively-driven. This Ph.D. dissertation examines the impact of various actors’ affective practices on the construction, enactment and contestation of affective borderscapes in the southeastern Mediterrane-an and its Aegean appendix, and explores how those processes manifest and link up at multiple scales across space and time from a perspective that accounts for the affective dimensions of border regimes aside from their legal, infrastructural and political causes and consequences. Through long-term ethnographic engagement with communities and individuals that have been passing through or inhabiting several locations along the much-fraught Aegean borders in times of major socioeconomic and geopolitical upheaval, this thesis formulates and puts forth the concept of affective borderscapes. They are liminal, overlapping landscapes that function as contact zones and as charged fields of affective interaction between assemblages of animate and inanimate actors. As an original contribution to border and migration studies, this concept bears great potential for the acquisition and mobilisation of knowledge, as well as for the design and application of human-centered policy and practice.
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