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Träfflista för sökning "WFRF:(Selva Erica M.) "

Search: WFRF:(Selva Erica M.)

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  • Lueders, Florian, et al. (author)
  • Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila.
  • 2003
  • In: EMBO Journal. - : Wiley. - 1460-2075. ; 22:14, s. 3635-3644
  • Journal article (peer-reviewed)abstract
    • Sulfation of all macromolecules entering the secretory pathway in higher organisms occurs in the Golgi and requires the high-energy sulfate donor adenosine 3'-phosphate 5'-phosphosulfate. Here we report the first molecular identification of a gene that encodes a transmembrane protein required to transport adenosine 3'-phosphate 5'-phosphosulfate from the cytosol into the Golgi lumen. Mutations in this gene, which we call slalom, display defects in Wg and Hh signaling, which are likely due to the lack of sulfation of glycos aminoglycans by the sulfotransferase sulfateless. Analysis of mosaic mutant ovaries shows that sll function is also essential for dorsal–ventral axis determination, suggesting that sll transports the sulfate donor required for sulfotransferase activity of the dorsal–ventral determinant pipe.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Häcker, Udo (1)
Perrimon, Norbert (1)
Lueders, Florian (1)
Segawa, Hiroaki (1)
Stein, David (1)
Selva, Erica M. (1)
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Turco, Salvatore J. (1)
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University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Year
2003 (1)

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