1. |
- Andersson, Maria, et al.
(author)
-
Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti)
- 1997
-
In: Planta Medica. - : Georg Thieme Verlag KG. - 0032-0943 .- 1439-0221. ; 63:3, s. 251-254
-
Journal article (peer-reviewed)abstract
- All sesquiterpenes present in a sample of scented myrrh were isolated and characterised. Seven compounds, with cadinane, guaiane, oplopane, and eudesmane skeletons, were obtained, of which two are new and two are reported from a natural source for the first time. The major component, T-cadinol, has previously been shown to possess smooth muscle-relaxing properties, and the major purpose of the investigation was to compare the effects of the minor and more polar sesquiterpenes with that of T-cadinol in the rat aorta. Like T-cadinol, the minor sesquiterpenes are more efficient in reducing K(+)-induced contractions than those induced by the alpha-adrenoceptor agonist phenylephrine, however, they were all less potent than T-cadinol.
|
|
2. |
- Bergendorff, Ola, et al.
(author)
-
Furanocoumarins with affinity to brain benzodiazepine receptors in vitro
- 1997
-
In: Phytochemistry. - 0031-9422. ; 44:6, s. 1121-1124
-
Journal article (peer-reviewed)abstract
- Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.
|
|