| 1. |
- Lorenzen, Eline D., et al.
(författare)
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Species-specific responses of Late Quaternary megafauna to climate and humans
- 2011
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 479:7373, s. 359-364
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Tidskriftsartikel (refereegranskat)abstract
- Despite decades of research, the roles of climate and humans in driving the dramatic extinctions of large-bodied mammals during the Late Quaternary period remain contentious. Here we use ancient DNA, species distribution models and the human fossil record to elucidate how climate and humans shaped the demographic history of woolly rhinoceros, woolly mammoth, wild horse, reindeer, bison and musk ox. We show that climate has been a major driver of population change over the past 50,000 years. However, each species responds differently to the effects of climatic shifts, habitat redistribution and human encroachment. Although climate change alone can explain the extinction of some species, such as Eurasian musk ox and woolly rhinoceros, a combination of climatic and anthropogenic effects appears to be responsible for the extinction of others, including Eurasian steppe bison and wild horse. We find no genetic signature or any distinctive range dynamics distinguishing extinct from surviving species, emphasizing the challenges associated with predicting future responses of extant mammals to climate and human-mediated habitat change.
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| 2. |
- Roy, Sushmita, et al.
(författare)
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Identification of functional elements and regulatory circuits by Drosophila modENCODE.
- 2010
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 330:6012, s. 1787-1797
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Tidskriftsartikel (refereegranskat)abstract
- To gain insight into how genomic information is translated into cellular and developmental programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) project is comprehensively mapping transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines. We have generated more than 700 data sets and discovered protein-coding, noncoding, RNA regulatory, replication, and chromatin elements, more than tripling the annotated portion of the Drosophila genome. Correlated activity patterns of these elements reveal a functional regulatory network, which predicts putative new functions for genes, reveals stage- and tissue-specific regulators, and enables gene-expression prediction. Our results provide a foundation for directed experimental and computational studies in Drosophila and related species and also a model for systematic data integration toward comprehensive genomic and functional annotation.
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| 3. |
- Rowlett, Julie, 1978, et al.
(författare)
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How to hear the corners of a drum
- 2019
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Ingår i: Matrix Annals. - Cham : Springer International Publishing. ; 2017, s. 243-278, s. 243-278
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Konferensbidrag (refereegranskat)abstract
- We prove that the existence of corners in a class of planar domain, which includes all simply connected polygonal domains and all smoothly bounded domains, is a spectral invariant of the Laplacian with both Neumann and Robin boundary conditions. The main ingredient in the proof is a locality principle in the spirit of Kac’s “principle of not feeling the boundary,” but which holds uniformly up to the boundary. Albeit previously known for Dirichlet boundary condition, this appears to be new for Robin and Neumann boundary conditions, in the geometric generality presented here. For the case of curvilinear polygons, we describe how the same arguments using the locality principle are insufficient to obtain the analogous result. However, we describe how one may be able to harness powerful microlocal methods and combine these with the locality principles demonstrated here to show that corners are a spectral invariant; this is current work-in-progress (Nursultanov et al., Preprint).
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