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- Patel, Riyaz S., et al.
(author)
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Subsequent Event Risk in Individuals With Established Coronary Heart Disease : Design and Rationale of the GENIUS-CHD Consortium
- 2019
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In: Circulation. - 2574-8300. ; 12:4
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Journal article (peer-reviewed)abstract
- BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints.CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.
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- Söderberg, Rebecka
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Displacing Diversity : How Social Mix Interventions are Legitimised, Experienced and Resisted in a Danish Neighbourhood
- 2024
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Doctoral thesis (other academic/artistic)abstract
- This doctoral thesis explores residents’ experiences of and resistance to social mix interventions, as well as how these interventions are legitimised in policies. This is studied through an ethnographic approach to policies combined with ethnographic fieldwork in a neighbourhood targeted by social mix interventions. In its empirical scope, the thesis is limited to a Scandinavian context, highlighting the perspectives of residents in a Danish neighbourhood targeted by the so-called ghetto legislation and comparing Danish and Swedish policies. The first article of this compilation thesis explores problematisations of urban diversity in Danish and Swedish urban and integration policies. It highlights processes of ‘selfing/othering’, showing how Danish policies construct the figure of ’the non-Western’ and myths of national sameness based on assumptions about cultural homogeneity, while Swedish policies construct the figure of ‘the unproductive’ based on assumptions about sameness as productiveness. The second article explores residents’ experiences of ongoing interventions for social mix. The analysis shows how residents live in conditions of evictability and how they are subjected to the discursive, material, and psychological violence of un-homing, i.e., residents are deprived of their home on multiple scales, even before relocation. The third article highlights how residents engage in various forms of resistance against displacement and commodification. The analysis emphasises how residents’ resistance is both individual and collective, material and discursive, discreet and confrontational. In addition, it shows how residents’ resistance is productive and ambiguous, producing new discourses, (dis)alliances, and places.Researching experiences of social mix interventions while they occur, this thesis adds new aspects to previous research, which is mainly concerned with whether social mix policies ‘work’. The analysis shows how social mix interventions have immediate, wide-reaching and unintended consequences, and highlights mundane and productive dimensions of processes of resistance.
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