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- Augustyniak, W., et al.
(författare)
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Polarization of a stored beam by spin-filtering
- 2012
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Ingår i: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 718:1, s. 64-69
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Tidskriftsartikel (refereegranskat)abstract
- The PAX Collaboration has successfully performed a spin-filtering experiment with protons at the COSY-ring. The measurement allowed the determination of the spin-dependent polarizing cross section, that compares well with the theoretical prediction from the nucleon-nucleon potential. The test confirms that spin-filtering can be adopted as a method to polarize a stored beam and that the present interpretation of the mechanism in terms of the proton-proton interaction is correct. The outcome of the experiment is of utmost importance in view of the possible application of the method to polarize a beam of stored antiprotons.
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- Strijbos, R. M., et al.
(författare)
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Health Economic Cost Analysis for Percutaneous Bone Conduction Devices: The Minimally Invasive Ponto Surgery Versus Linear Incision Technique with Tissue Preservation
- 2023
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Ingår i: Otology & Neurotology. - 1531-7129. ; 44:7, s. 709-717
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Tidskriftsartikel (refereegranskat)abstract
- ObjectivesTo identify differences in mean cost per patient between the Minimally Invasive Ponto Surgery (MIPS) and the linear incision technique with tissue preservation (LITT-P).Study designHealth economic cost analysis.SettingThe analysis was performed in a randomized multicenter controlled trial cohort.PatientsAdult patients eligible for unilateral bone conduction device surgery.InterventionsMIPS versus LITT-P surgery for bone conduction device implantation.Main outcome measuresPerioperative and postoperative costs were identified and compared.ResultsThe difference in mean cost per patient between both techniques was euro77.83 in favor of the MIPS after 22 months follow-up. The mean costs per patient were lower in the MIPS cohort for surgery (euro145.68), outpatient visits (euro24.27), systemic antibiotic therapy with amoxicillin/clavulanic acid (euro0.30) or clindamycin (euro0.40), abutment change (euro0.36), and abutment removal (euro0.18). The mean costs per patient were higher for implant and abutment set (euro18.00), topical treatment with hydrocortison/oxytetracycline/polymyxine B (euro0.43), systemic therapy with azithromycin (euro0.09) or erythromycin (euro1.15), local revision surgery (euro1.45), elective explantation (euro1.82), and implant extrusion (euro70.42). Additional analysis of scenarios in which all patients were operated under general or local anesthesia or with recalculation when using current implant survival rates showed that differences in mean cost per patient were also in favor of the MIPS.ConclusionThe difference between the MIPS and the LITT-P in mean cost per patient was euro77.83 in favor of the MIPS after 22 months of follow-up. The MIPS is an economically responsible technique and could be promising for the future.
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| 3. |
- van den Born, Jacob, et al.
(författare)
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No change in glomerular heparan sulfate structure in early human and experimental diabetic nephropathy
- 2006
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Ingår i: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 281:40, s. 29606-29613
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Tidskriftsartikel (refereegranskat)abstract
- Heparan sulfate (HS) proteoglycans are major anionic glycoconjugates of the glomerular basement membrane and are thought to contribute to the permeability properties of the glomerular capillary wall. In this study we evaluated whether the development of ( micro) albuminuria in early human and experimental diabetic nephropathy is related to changes in glomerular HS expression or structure. Using a panel of recently characterized antibodies, glomerular HS expression was studied in kidney biopsies of type I diabetic patients with microalbuminuria or early albuminuria and in rat renal tissue after 5 months diabetes duration. Glomerular staining, however, revealed no differences between control and diabetic specimens. A significant (p < 0.05) similar to 60% increase was found in HS N-deacetylase activity, a key enzyme in HS sulfation reactions, in diabetic glomeruli. Structural analysis of glomerular HS after in vivo and in vitro radiolabeling techniques revealed no changes in HS N-sulfation or charge density. Also HS chain length, protein binding properties, as well as disaccharide composition did not differ between control and diabetic glomerular HS samples. These results indicate that in experimental and early human diabetic nephropathy, increased urinary albumin excretion is not caused by loss of glomerular HS expression or sulfation and suggest other mechanisms to be responsible for increased glomerular albumin permeability.
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