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| 2. |
- Ida, Shigeru, et al.
(författare)
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Slowing Down Type II Migration of Gas Giants to Match Observational Data
- 2018
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 864:1
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Tidskriftsartikel (refereegranskat)abstract
- The mass and semimajor axis distribution of gas giants in exoplanetary systems obtained by radial velocity surveys shows that super-Jupiter-mass planets are piled up at 1 au, while Jupiter/sub-Jupiter-mass planets are broadly distributed from ∼0.03 au to beyond 1 au. This feature has not been explained by theoretical predictions. In order to reconcile this inconsistency, we investigate evolution of gas giants with a new type II migration formula by Kanagawa et al., by comparing the migration, growth timescales of gas giants, and disk lifetime, and by population synthesis simulation. While the classical migration model assumes that a gas giant opens up a clear gap in the protoplanetary disk and the planet migration is tied to the disk gas accretion, recent high-resolution simulations show that the migration of gap-opening planets is decoupled from the disk gas accretion and Kanagawa et al. proposed that type II migration speed is nothing other than type I migration speed with the reduced disk gas surface density in the gap. We show that with this new formula, type II migration is significantly reduced for super-Jupiter-mass planets, if the disk accretion is driven by the disk wind as suggested by recent magnetohydrodynamic simulations. Population synthesis simulations show that super-Jupiter-mass planets remain at 1 au without any additional ingredient such as disk photoevaporation. Therefore, the mystery of the pile-up of gas giants at 1 au will be theoretically solved if the new formula is confirmed and wind-driven disk accretion dominates.
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| 3. |
- Okada, Shigeru, et al.
(författare)
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Growth and some properties of Sc2AlB6 crystal obtained from the solution in aluminium melt
- 2004
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Ingår i: Journal of Solid State Chemistry. - : Elsevier BV. - 0022-4596. ; 177:2, s. 547-550
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Tidskriftsartikel (refereegranskat)abstract
- Crystals of Sc2AlB6 were grown using scandium oxide and elemental boron as starting materials in a self-component aluminum solution under an argon atmosphere. The growth conditions for obtaining single crystals of relatively large size were investigated. Sc2AlB6 single crystals were obtained in the form of prisms extending in the b-axis direction. The largest Sc2AlB6 crystals prepared had maximum dimensions of about 0.4×0.4×4.2 mm3. The values of the Vickers microhardness and the electrical resistivity of Sc2AlB6 crystals are 12.7±0.8 GPa and 43±8 cm, respectively. The oxidation of Sc2AlB6 crystals starts at about 773°C, and the weight gain after TG determination is 12.9 mass% at 1200°C. The oxidation products of Sc2AlB6 crystals could not determined.
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| 4. |
- Qi, Qibin, et al.
(författare)
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FTO genetic variants, dietary intake and body mass index : insights from 177 330 individuals
- 2014
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:25, s. 6961-6972
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Tidskriftsartikel (refereegranskat)abstract
- FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.
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| 5. |
- Shoda, Jumpei, et al.
(författare)
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Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium
- 2022
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Ingår i: Arthritis Research & Therapy. - : BioMed Central (BMC). - 1478-6362. ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- Objectives Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA). However, the precise mechanisms by which MTX stalls RA progression and alleviates the ensuing disease effects remain unknown. The aim of the present study was to identify novel therapeutic target molecules, the expression patterns of which are affected by MTX in patients with RA. Methods CD4(+) T cells from 28 treatment-naive patients with RA before and 3 months after the initiation of MTX treatment were subjected to DNA microarray analyses. The expression levels of semaphorin 3G, a differentially expressed gene, and its receptor, neuropilin-2, were evaluated in the RA synovium and collagen-induced arthritis synovium. Collagen-induced arthritis and collagen antibody-induced arthritis were induced in semaphorin3G-deficient mice and control mice, and the clinical score, histological score, and serum cytokines were assessed. The migration and proliferation of semaphorin 3G-stimulated bone marrow-derived macrophages were analyzed in vitro. The effect of local semaphorin 3G administration on the clinical score and number of infiltrating macrophages during collagen antibody-induced arthritis was evaluated. Results Semaphorin 3G expression in CD4(+) T cells was downregulated by MTX treatment in RA patients. It was determined that semaphorin 3G is expressed in RA but not in the osteoarthritis synovium; its receptor neuropilin-2 is primarily expressed on activated macrophages. Semaphorin3G deficiency ameliorated collagen-induced arthritis and collagen antibody-induced arthritis. Semaphorin 3G stimulation enhanced the migration and proliferation of bone marrow-derived macrophages. Local administration of semaphorin 3G deteriorated collagen antibody-induced arthritis and increased the number of infiltrating macrophages. Conclusions Upregulation of semaphorin 3G in the RA synovium is a novel mechanism that exacerbates joint inflammation, leading to further deterioration, through macrophage accumulation.
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| 6. |
- Takata, Naoki, 1979-, et al.
(författare)
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Phylogenetic footprint of the plant clock system in angiosperms : evolutionary processes of Pseudo-Response Regulators
- 2010
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Ingår i: BMC Evolutionary Biology. - : BMC Evolutionary Biology. - 1471-2148. ; 10, s. 126-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Plant circadian clocks regulate many photoperiodic and diurnal responses that are conserved among plant species. The plant circadian clock system has been uncovered in the model plant, Arabidopsis thaliana, using genetics and systems biology approaches. However, it is still not clear how the clock system had been organized in the evolutionary history of plants. We recently revealed the molecular phylogeny of LHY/CCA1 genes, one of the essential components of the clock system. The aims of this study are to reconstruct the phylogenetic relationships of angiosperm clock-associated PRR genes, the partner of the LHY/CCA1 genes, and to clarify the evolutionary history of the plant clock system in angiosperm lineages. Results: In the present study, to investigate the molecular phylogeny of PRR genes, we performed two approaches: reconstruction of phylogenetic trees and examination of syntenic relationships. Phylogenetic analyses revealed that PRR genes had diverged into three clades prior to the speciation of monocots and eudicots. Furthermore, copy numbers of PRR genes have been independently increased in monocots and eudicots as a result of ancient chromosomal duplication events. Conclusions: Based on the molecular phylogenies of both PRR genes and LHY/CCA1 genes, we inferred the evolutionary process of the plant clock system in angiosperms. This scenario provides evolutionary information that a common ancestor of monocots and eudicots had retained the basic components required for reconstructing a clock system and that the plant circadian clock may have become a more elaborate mechanism after the speciation of monocots and eudicots because of the gene expansion that resulted from polyploidy events.
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