| 1. |
- Frøkedal, Hilde, et al.
(författare)
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Participation in Existential Groups Led by Norwegian Healthcare Chaplains : Relations to Psychological Distress, Crisis of Meaning and Meaningfulness
- 2022
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Ingår i: The international journal for the psychology of religion. - : Routledge. - 1050-8619 .- 1532-7582. ; 32:1, s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- Spirituality groups led by healthcare chaplains have been found to aid patients' recovery processes in US psychiatric units. In Norway, existential groups (EGs) led by healthcare chaplains and co-led by healthcare staff members are offered at psychiatric units; these groups share commonalities with spirituality groups, group psychotherapy, existential therapy and clinical pastoral care, facilitating patients' reflections regarding existential, spiritual and religious issues. The study aimed to examine associations between patients' participation and topics discussed in the EGs and their experiences of psychological distress, crisis of meaning and meaningfulness. A cross-sectional design was applied among 157 patients attending EGs led by healthcare chaplains across Norway. Multivariate regression analyses assessed the strength of possible associations, adjusted for relevant demographical variables. Significant association was found between lengthier EG participation and lower levels of psychological distress, while discussion topics concerning religious and spiritual issues were significantly associated with the experience of meaningfulness.
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| 2. |
- In ’t Veld, Sjors G.J.G., et al.
(författare)
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Detection and localization of early- and late-stage cancers using platelet RNA
- 2022
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Ingår i: Cancer Cell. - : Elsevier. - 1535-6108 .- 1878-3686. ; 40:9, s. 999-1009.e6
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Tidskriftsartikel (refereegranskat)abstract
- Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I–IV cancer patients and in half of 352 stage I–III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening.
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| 3. |
- van 't Hoff, Merel L. R., et al.
(författare)
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Imaging the water snowline in a protostellar envelope with (HCO+)-C-13
- 2018
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 613
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Tidskriftsartikel (refereegranskat)abstract
- Context. Snowlines are key ingredients for planet formation. Providing observational constraints on the locations of the major snowlines is therefore crucial for fully connecting planet compositions to their formation mechanism. Unfortunately, the most important snowline, that of water, is very difficult to observe directly in protoplanetary disks because of the close proximity of this snowline to the central star. Aims. Based on chemical considerations, HCO+ is predicted to be a good chemical tracer of the water snowline because it is particularly abundant in dense clouds when water is frozen out. This work aims to map the optically thin isotopolog (HCO+)-C-13 toward the envelope of the low-mass protostar NGC1333-IRAS2A, where the snowline is at a greater distance from the star than in disks. Comparison with previous observations of (H2O)-O-18 show whether (HCO+)-C-13 is indeed a good tracer of the water snwline. Methods. NGC1333-IRAS2A was observed using the NOrthern Extended Millimeter Array (NOEMA) at similar to 0:0.9 resolution, targeting the (HCO+)-C-13 J = 3-2 transition at 260.255 GHz. The integrated emission profile was analyzed using 1D radiative transfer modeling of a spherical envelope with a parametrized abundance profile for (HCO+)-C-13. This profile was validated with a full chemical model. Results. The (HCO+)-C-13 emission peaks similar to 2" northeast of the continuum peak, whereas (H2O)-O-18 sh ows compact emission on source. Quantitative modeling shows that a decrease in (HCO+)-C-13 abundance by at least a factor of six is needed in the inner similar to 360 AU to reproduce the observed emission profile. Chemical modeling indeed predicts a steep increase in HCO+ just outside the water snowline; the 50% decrease in gaseous H2O at the snowline is not enough to allow HCO+ to be abundant. This places the water snowline at 225 AU, further away from the star than expected based on the 1D envelope temperature structure for NGC1333-IRAS2A. In contrast, DCO+ observations show that the CO snowline is at the expected location, making an outburst scenario unlikely. Conclusions. The spatial anticorrelation of (HCO+)-C-13 and (H2O)-O-18 emission provide proof of concept that (HCO+)-C-13 can be used as a tracer of the water snowline.
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