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Sökning: WFRF:(Wadsworth Emma J K)

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1.
  • Cardoso, Ricardo, et al. (författare)
  • BLOCOS URBANISM : Capitalism and Modularity in the Making of Contemporary Luanda
  • 2023
  • Ingår i: International Journal of Urban and Regional Research. - : Wiley. - 0309-1317 .- 1468-2427. ; 47:5, s. 809-832
  • Tidskriftsartikel (refereegranskat)abstract
    • In this article we portray and unpack the fabric of urban expansion in contemporary Luanda. In doing so, we examine interdependencies and complementarities between the organization of oil extraction off the coast of Angola, the emergence of particular modalities of modernist city planning for the expansion of its capital city, and the proliferation of cement blocks in the making of new urban forms throughout its burgeoning peripheries. By showing how urban development has unfolded through the interconnected realization of multiple kinds of systematizing blocks—namely oil blocks, city blocks and cement blocks—we analyse key material components in the production of new markets and urban spaces in the Angolan capital. By tracing forms of capitalism and modularity in the making of contemporary Luanda, we develop the concept of blocos urbanism to draw attention to modes of standardization and the production of legibility in contemporary processes of urbanization. Through this study, we aim to contribute to the conceptual apparatus for deciphering our global urban condition.
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2.
  • Cardoso, Simone J., et al. (författare)
  • Spatial variation of sediment mineralization supports differential CO2 emissions from a tropical hydroelectric reservoir
  • 2013
  • Ingår i: Frontiers in Microbiology. - : Frontiers Media SA. - 1664-302X. ; 4, s. 101-
  • Tidskriftsartikel (refereegranskat)abstract
    • Substantial amounts of organic matter (OM) from terrestrial ecosystems are buried as sediments in inland waters. It is still unclear to what extent this OM constitutes a sink of carbon, and how much of it is returned to the atmosphere upon mineralization to carbon dioxide (CO2). The construction of reservoirs affects the carbon cycle by increasing OM sedimentation at the regional scale. In this study we determine the OM mineralization in the sediment of three zones (river, transition, and dam) of a tropical hydroelectric reservoir in Brazil as well as identify the composition of the carbon pool available for mineralization. We measured sediment organic carbon mineralization rates and related them to the composition of the OM, bacterial abundance and pCO2 of the surface water of the reservoir. Terrestrial OM was an important substrate for the mineralization. In the river and transition zones most of the OM was allochthonous (56 and 48%, respectively) while the dam zone had the lowest allochthonous contribution (7%). The highest mineralization rates were found in the transition zone (154.80 ± 33.50 mg C m-2 d-1) and the lowest in the dam (51.60 ± 26.80 mg C m-2 d-1). Moreover, mineralization rates were significantly related to bacterial abundance (r2= 0.50, p < 0.001) and pCO2 in the surface water of the reservoir (r2 = 0.73, p < 0.001). The results indicate that allochthonous OM has different contributions to sediment mineralization in the three zones of the reservoir. Further, the sediment mineralization, mediated by heterotrophic bacteria metabolism, significantly contributes to CO2supersaturation in the water column, resulting in higher pCO2 in the river and transition zones in comparison with the dam zone, affecting greenhouse gas emission estimations from hydroelectric reservoirs.
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4.
  • Cardoso, Rebeca Franco (författare)
  • Beyond Th1 and Treg : intestinal T helper cells in disease and tolerance
  • 2022
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The human intestinal tract is not only one of the largest organs by surface area in our bodies but also harbors the greatest number of immune cells. These cells are crucial for maintaining tolerance towards the various food and microbial antigens and mounting protective inflammatory responses towards invading pathogens. Inasmuch, a delicate balance exists between anti- and pro-inflammatory signals which are influenced by several factors and must remain in check to ensure appropriate responses towards innocuous and harmful stimuli. To this end, CD4+ T helper (Th) cells play a crucial role in orchestrating both tolerogenic and proinflammatory responses. This thesis sought to better understand the factors controlling Th cells in the context of different intestinal challenges. In Studies I and II, we investigated how dietary cholesterol sensing can influence Th phenotypes during homeostasis. In Study I, we found that the liver X receptors (LXRs)— which senses oxidized forms of cholesterol—influence the balance of Foxp3+RORgt+ regulatory T cells (RORgt+ Tregs) and Foxp3-RORgt+ Th17 cells in the gut-draining mesenteric lymph nodes (MLNs). Differences in the microbiota could explain the changes in Th17 frequencies but not RORgt+ Tregs. Instead, we found that LXR signaling in CD11c+ cells altered the RORgt+ Treg population. In Study II, we found that ingestion of the LXR agonist GW3965 led to changes in the frequencies in the IL-10+ Foxp3+ Treg populations in the small intestine and spleen. Interestingly, while GW3965 led to a decrease in IL-10+ Tregs the small intestine, it decreased their frequency in the spleen. Intriguingly, mice lacking LXR signaling in CD11c+ cells failed to develop oral tolerance. Together, these studies demonstrate the importance of cholesterol sensing during steady state. In Study III, we tracked the activation of naïve Th cells recognizing the commensal CBir1 antigen (CBir1 cells). We found that naïve CBir1 cells could be activated in the MLNs following dextran sulfate sodium (DSS)-induced colitis and that, once activated, they were preferentially skewed towards an effector rather than regulatory T cell phenotype which was plastic over time. Furthermore, while CBir1 cells were not pathogenic on their own, they led to increased disease score in a T cell-driven mouse model of colitis. In Study IV, we analyzed how infection with the strictly enteric helminth Heligmosomoides polygyrus bakeri (H. polygyrus) could influence Th cell populations in the skin. H. polygyrus infection led to an increase in the number of Th cells in the skin. Interestingly, this was not due to translocation of bacteria or general intestinal inflammation. Instead, H. polygyrus infection led to an increase in MLN Th cells expressing the skin-homing receptors CCR4 and CCR10. Taken together, the results in this thesis highlight the importance of cholesterol sensing and intestinal inflammation in controlling the fate of CD4+ Th cells in the gut and beyond.
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5.
  • Cardoso, Roberto Speicys, et al. (författare)
  • Exploring Multi-Path Communication in Hybrid Mobile Ad Hoc Networks
  • 2010
  • Ingår i: International Journal of Ambient Computing and Intelligence (IJACI). - : IGI Global. - 1941-6237 .- 1941-6245. ; 2:4, s. 1-12
  • Tidskriftsartikel (refereegranskat)abstract
    • Ambient computing requires the integration of multiple mobile heterogeneous networks. Multi-path communication in such scenarios can provide reliability and privacy benefits. Even though the properties of multi-path routing have been extensively studied and a number of algorithms proposed, implementation of such techniques can be tricky, particularly when resource-constrained nodes are connected to each other through hybrid networks with different characteristics. In this paper, the authors discuss the challenges involved in implementing multipath communication on a middleware for hybrid mobile ad hoc networks. The authors present the PLASTIC middleware, several compelling applications of multi-path communication and the main issues concerning their implementation as a primitive middleware-provided communication.
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