| 1. |
|
|
| 2. |
|
|
| 3. |
- Dreilich, Martin, 1970-
(författare)
-
Predictive Factors in Esophageal Carcinoma
- 2006
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Esophageal carcinoma is a malignancy with a poor prognosis and is the sixth cause of cancer related death worldwide. In Sweden approximately 400 new cases are diagnosed every year. The aim of this present thesis was to investigate predictive factors for esophageal carcinoma patients.126 esophageal carcinoma patients admitted to the department of Oncology at the University Hospital in Uppsala between 1990-2000 were investigated with focus on known and potential prognostic factors. Performance status and stage of the disease were the only independent prognostic factors (p-values <0.001). Angiogenic factors VEGF and bFGF were correlated to platelet and leukocyte counts and VEGF was correlated to tumor volume (p=0.04) whereas bFGF was not (p=0.08) in pre-treatment serum samples from 42 esophageal carcinoma patients. The use of the angiogenic factors as prognostic factors, prior to therapy in patients with esophageal carcinoma, according to the results from the present study, seems limited. HER-2 overexpression was seen in 17% of 97 investigated esophageal tumor samples. In squamous cell carcinoma patients, HER-2 overexpression correlated with poorer survival (p=0.035), whereas in adenocarcinoma patients, HER-2 status did not. HER-2 overexpression seems to be associated with poorer survival in esophageal carcinomas, especially in patients with squamous cell esophageal carcinoma. Telomerase activity was detected in all esophageal cell lines, with a broad range of activity levels. No correlation was found between telomerase activity levels and sensitivity to investigated cytotoxic drugs. We therefore conclude that basal telomerase activity level is not a key determinant of sensitivity to standard cytotoxic drugs in esophageal carcinoma cell lines. The virus HPV-16 was detected in 16 % of the patients; no other type HPV was detected. HPV-16 infection had no significant effect on survival (p=0.72). Our results did not show that HPV-16 increases survival or improve therapy response in patients with esophageal carcinoma.
|
|
| 4. |
- Dreilich, Martin, et al.
(författare)
-
Telomerase activity is not a key determinant of sensitivity to standard cytotoxic drugs in human esophageal carcinoma cell lines
- 2006
-
Ingår i: Anti-Cancer Drugs. - 0959-4973 .- 1473-5741. ; 17:5, s. 503-509
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of the present study was to investigate if basal telomerase activity levels may predict sensitivity to cytotoxic drugs in a panel of human esophageal carcinoma cell lines. The TRAPeze telomerase detection assay was used to investigate telomerase activity in the cell lines. Cytotoxic drug sensitivity for 20 standard cytotoxic agents was assessed using the fluorometric microculture cytotoxicity assay (FMCA). Telomerase activity was detected in all cell lines with a broad range of activity levels. Drug sensitivity also varied considerably between the cell lines. Except for a P value towards a correlation between mitoxantrone and telomerase activity (P=0.054), no statistically significant correlation was found between telomerase activity levels and sensitivity to investigated drugs, including key drugs such as cisplatin (P=0.9), 5-fluorouracil (P=0.8) and doxorubicin (P=0.54). We therefore conclude that basal telomerase activity level is not a key determinant of sensitivity to standard cytotoxic drugs in esophageal carcinoma cell lines.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Snyder, Kristen, et al.
(författare)
-
Building International education networks through ICT : Possibilities and Challenges
- 2002
-
Ingår i: Internationalisation in a shrinking world. - Eisenstadt : Stiftung Pädagogische Akademie Burgenland. - 3831147361 ; , s. 240-
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter focuses on the use of a social network model for shaping professional development among educators in an international learning context. Findings from a three-year study show that the social network is a powerful model for professional development, and that the ICT context and international relations add important dimensions to teacher and leader development in the global age.
|
|
| 8. |
- Snyder, Kristen, et al.
(författare)
-
International Connections through ICT : Expanding the training and development of teachers and school leaders
- 2002
-
Ingår i: Internationalisation in a shrinking world. - Eisenstadt : Stiftung Pädagogische Akademie Burgenland. - 3831147361 ; , s. 240-
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter discusses the use of ICT in an international learning environment for educators as a tool for facilitating cross-cultural collaborative learning. Examined are aspects of ICT in this international professional development context, including time, language, decision making, group dynamics, and communication.
|
|
| 9. |
|
|
| 10. |
- Snyder, Kristen M, 1964-, et al.
(författare)
-
The Rainbow Runners : A Sleddog Adventure
- 2021. - 1
-
Bok (populärvet., debatt m.m.)abstract
- The Rainbow Runners is a true story of a sled dog adventure told by Alaskan Husky, Nija JaJa, the youngest member of the team, who along with her “Uncle Buncles” and brother set out to follow a dream to participate in a long-distance race through the mountains. The story takes place in the white-capped mountains of Sweden. The book begins with a dream to prepare for a 250-kilometer long distance sled dog race through the Swedish Mountains. With fewer dogs in the team than is common for such a race, the team begins their journey with an uphill battle. During preparations for the race the dogs experience what it means to build a team, and not just a functioning team, but a team that is flexible and adaptable to changing conditions; a team that is built on recognizing and celebrating the unique strengths in each team member; and a team that keeps sight on their own dream, even when others doubt their ability.Among the issues focused on in the book are teambuilding, vision, goal setting and strategic planning, diversity, and leadership.
|
|
