| 1. |
- Hammami, Feras, 1978, et al.
(författare)
-
Heritage and peacebuilding : Challenges, possibilities and sustainable practices
- 2022
-
Ingår i: Routledge Handbook of Sustainable Heritage. - London : Routledge. - 9781003038955 - 9781000594850 ; , s. 241-260
-
Bokkapitel (refereegranskat)abstract
- This handbook presents cutting-edge and global insights on sustainable heritage, engaging with ideas such as data science in heritage, climate change and environmental challenges, indigenous heritage, contested heritage and resilience. It does so across a diverse range of global heritage sites.Organized into six themed parts, the handbook offers cross-disciplinary perspectives on the latest theory, research and practice. Thirty-five chapters offer insights from leading scholars and practitioners in the field as well as early career researchers. This book fills a lacuna in the literature by offering scientific approaches to sustainable heritage, as well as multicultural perspectives by exploring sustainable heritage in a range of different geographical contexts and scales. The themes covered revolve around heritage values and heritage risk; participatory approaches to heritage; dissonant heritage; socio-environmental challenges to heritage; sustainable heritage-led transformation and new cross-disciplinary methods for heritage research.This book will be an invaluable resource for students and scholars in heritage studies, archaeology, museum studies, cultural studies, architecture, landscape, urban design, planning, geography and tourism.
|
|
| 2. |
-
Heritage and peacebuilding
- 2017
-
Samlingsverk (redaktörskap) (refereegranskat)abstract
- Case-studies of whether and how heritage can be used to bring about reconciliation. This volume explores one of the most critical issues of our time: whether heritage can contribute to a more peaceful society and future. It reflects a core belief that heritage can provide solutions to reconciling peoples and demonstrates the amount of significant work being carried out internationally. Based round the core themes of new and emerging ideas around heritage and peace, heritage and peace-building in practice, and heritage, peace-building and sites, the twenty contributions seek to raise perceptions and understanding of heritage-based peace-building practices. Responding to the emphasis placed on conflict, war and memorialization, they reflect exploratory yet significant steps towards reclaiming the history, theory, and practice of peacebuilding as serious issues for heritage in contemporary society. The geographical scope of the book includes contributions from Europe, notably the Balkans and Northern Ireland, the Middle East, and Kenya. Diana Walters is an International Heritage Consultant and Honorary Senior Research Fellow at the University of Exeter; Daniel Laven is Associate Professor of Human Geography, Department of Tourism Studies and Geography/European Tourism Research Institute (ETOUR), Mid Sweden University; Peter Davis is Emeritus Professor of Museology, Newcastle University. Contributors: Tatjana Cvjeticanin, Peter Davis, Jonathan Eaton, David Fleming, Seth Frankel, Timothy Gachanga, Alon Gelbman, Felicity Gibling, Will Glendinning, Elaine Heumann Gurian, Lejla Hadzic, Feras Hammami, Lotte Hughes, Bosse Lagerqvist, Daniel Laven, Bernadette Lynch, Elena Monicelli, Yongtanit Pimonsathean, Saleem H. Ali, Sultan Somjee, Peter Stone, Michèle Taylor, Peter van den Dungen, Alda Vezic, Jasper Visser, Diana Walters.
|
|
| 3. |
- Lagerqvist, Bosse, 1957, et al.
(författare)
-
Reclaiming a divided heritage - Bhopal after Union Carbide
- 2011
-
Ingår i: Asian urban heritage. Proceedings ICOMOS Thailand International Conference 2011, Phuket Town, THAILAND 15-17, October 15-17, 2011. - Bangkok : ICOMOS Thailand. - 9786169059943 ; , s. 34-47
-
Konferensbidrag (refereegranskat)abstract
- The decision to create a memorial on the site of the Union Carbide India Limited factory represents an opportunity to mark one of the worst industrial accidents on record. The derelict site of the former factory has acquired iconic status as a landmark in a thriving city and has come to represent many things; shame, pain, embarrassment, anger, sorrow and ongoing demands for justice to name but a few. Divisions and multiple narratives remain amongst the many and often divided stakeholders. The process of heritage management offers an opportunity for participatory and inclusive practice in the creation of a memorial / museum. This paper explores the case of Bhopal within the context of the need for a broad interdisciplinary approach that embraces industrial heritage as a relevant force for contemporary society and a contributor to the goals of active memorialization. The authors were both participants in the modern Asian Architectural Network Workshop and Symposium in Bhopal in January 2011 and are part of an international consortium of researchers supporting the architects Space Matters who in 2005 won the governmentally initiated architectural competition for developing the site.
|
|
| 4. |
- Palmer, Nicholette D, et al.
(författare)
-
A genome-wide association search for type 2 diabetes genes in African Americans.
- 2012
-
Ingår i: PloS one. - San Francisco : Public Library of Science (PLoS). - 1932-6203. ; 7:1, s. e29202-
-
Tidskriftsartikel (refereegranskat)abstract
- African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.
|
|
| 5. |
- Sonderby, Ida E., et al.
(författare)
-
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
- 2020
-
Ingår i: Molecular Psychiatry. - : Nature Publishing Group. - 1359-4184 .- 1476-5578. ; 25:3, s. 584-602
-
Tidskriftsartikel (refereegranskat)abstract
- Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β = −0.71 to −1.37; P < 0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (β = −0.95, P = 0.0042). The two data sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P = 0.0032, 8.9 × 10−6, 1.7 × 10−9, 3.5 × 10−12 and 1.0 × 10−4, respectively). Full scale IQ was lower in both deletion and duplication carriers compared to non-carriers. This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes.
|
|
| 6. |
- Speliotes, Elizabeth K., et al.
(författare)
-
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- 2010
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
-
Tidskriftsartikel (refereegranskat)abstract
- Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
|
|
| 7. |
- Sønderby, Ida E., et al.
(författare)
-
1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
- 2021
-
Ingår i: Translational Psychiatry. - : Nature Publishing Group. - 2158-3188. ; 11:1
-
Tidskriftsartikel (refereegranskat)abstract
- Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Human carriers display a high prevalence of micro- and macrocephaly in deletion and duplication carriers, respectively. The underlying brain structural diversity remains largely unknown. We systematically called CNVs in 38 cohorts from the large-scale ENIGMA-CNV collaboration and the UK Biobank and identified 28 1q21.1 distal deletion and 22 duplication carriers and 37,088 non-carriers (48% male) derived from 15 distinct magnetic resonance imaging scanner sites. With standardized methods, we compared subcortical and cortical brain measures (all) and cognitive performance (UK Biobank only) between carrier groups also testing for mediation of brain structure on cognition. We identified positive dosage effects of copy number on intracranial volume (ICV) and total cortical surface area, with the largest effects in frontal and cingulate cortices, and negative dosage effects on caudate and hippocampal volumes. The carriers displayed distinct cognitive deficit profiles in cognitive tasks from the UK Biobank with intermediate decreases in duplication carriers and somewhat larger in deletion carriers-the latter potentially mediated by ICV or cortical surface area. These results shed light on pathobiological mechanisms of neurodevelopmental disorders, by demonstrating gene dose effect on specific brain structures and effect on cognitive function.
|
|
| 8. |
- van der Meer, Dennis, et al.
(författare)
-
Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition
- 2020
-
Ingår i: JAMA psychiatry. - : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 77:4, s. 420-430
-
Tidskriftsartikel (refereegranskat)abstract
- Importance: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities.Objective: To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive task performance.Design, Setting, and Participants: In this genetic association study, T1-weighted brain magnetic resonance imaging were combined with genetic data from the ENIGMA-CNV consortium and the UK Biobank, with a replication cohort from Iceland. In total, 203 deletion carriers, 45 247 noncarriers, and 306 duplication carriers were included. Data were collected from August 2015 to April 2019, and data were analyzed from September 2018 to September 2019.Main Outcomes and Measures: The associations of the CNV with global and regional measures of surface area and cortical thickness as well as subcortical volumes were investigated, correcting for age, age2, sex, scanner, and intracranial volume. Additionally, measures of cognitive ability were analyzed in the full UK Biobank cohort.Results: Of 45 756 included individuals, the mean (SD) age was 55.8 (18.3) years, and 23 754 (51.9%) were female. Compared with noncarriers, deletion carriers had a lower surface area (Cohen d = -0.41; SE, 0.08; P = 4.9 × 10-8), thicker cortex (Cohen d = 0.36; SE, 0.07; P = 1.3 × 10-7), and a smaller nucleus accumbens (Cohen d = -0.27; SE, 0.07; P = 7.3 × 10-5). There was also a significant negative dose response on cortical thickness (β = -0.24; SE, 0.05; P = 6.8 × 10-7). Regional cortical analyses showed a localization of the effects to the frontal, cingulate, and parietal lobes. Further, cognitive ability was lower for deletion carriers compared with noncarriers on 5 of 7 tasks.Conclusions and Relevance: These findings, from the largest CNV neuroimaging study to date, provide evidence that 15q11.2 BP1-BP2 structural variation is associated with brain morphology and cognition, with deletion carriers being particularly affected. The pattern of results fits with known molecular functions of genes in the 15q11.2 BP1-BP2 region and suggests involvement of these genes in neuronal plasticity. These neurobiological effects likely contribute to the association of this CNV with neurodevelopmental disorders.
|
|
| 9. |
|
|
| 10. |
- Walters, Diana, et al.
(författare)
-
Introduction
- 2017
-
Ingår i: Heritage and peacebuilding. - Woodbridge : Boydell & Brewer. - 9781783272167 ; , s. 1-4
-
Bokkapitel (refereegranskat)
|
|
