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Träfflista för sökning "WFRF:(Wikman A.) "

Search: WFRF:(Wikman A.)

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  • Agren, A, et al. (author)
  • In response
  • 2014
  • In: Anesthesia and analgesia. - 1526-7598. ; 119:6, s. 1453-1453
  • Journal article (other academic/artistic)
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  • Almskog, LM, et al. (author)
  • A retrospective register study comparing fibrinogen treated trauma patients with an injury severity score matched control group
  • 2020
  • In: Scandinavian journal of trauma, resuscitation and emergency medicine. - : Springer Science and Business Media LLC. - 1757-7241. ; 28:1, s. 5-
  • Journal article (peer-reviewed)abstract
    • BackgroundFibrinogen concentrate (FC) is frequently used to treat bleeding trauma patients, although the clinical effects are not well known. In this study we describe demographic and clinical outcome data in a cohort of trauma patients receiving FC, compared to a matched control group, who did not receive FC.MethodsThis retrospective, single-center, observational study included adult trauma patients admitted to a level 1-trauma center in Sweden between January 2013 and June 2015. The study population consisted of patients to whom FC was administrated within 24 h (n = 138, “Fib+”). Patients with Injury Severity Score (ISS) > 49 and/or deceased within 1 h from arrival were excluded (n = 30). Controls (n = 108) were matched for age, gender and ISS (“Fib-“). Primary outcome was mortality (24 h−/30 days−/1 year-), and secondary outcomes were blood transfusions, thromboembolic events and organ failure.ResultsThe Fib+ group, despite having similar ISS as Fib-, had higher prevalence of penetrating trauma and lower Glasgow Coma Scale (GCS), indicating more severe injuries. Patients receiving FC had a higher mortality after 24 h/ 30 days/ 1 year compared to controls (Fib-). However, in a propensity score matched model, the differences in mortality between Fib+ and Fib- were no longer significant. Blood transfusions were more common in the Fib+ group, but no difference was observed in thromboembolic events or organ failure. In both groups, low as well as high P-fibrinogen levels at arrival were associated with increased mortality, with the lowest mortality observed at P-fibrinogen values of 2–3 g/l.ConclusionsDespite equal ISS, patients receiving FC had a higher mortality compared to the control group, presumably associated to the fact that these patients were bleeding and physiologically deranged on arrival. When applying a propensity score matching approach, the difference in mortality between the groups was no longer significant. No differences were observed between the groups regarding thromboembolic events or organ failure, despite higher transfusion volumes in patients receiving FC.
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  • Result 1-10 of 180
Type of publication
journal article (138)
conference paper (35)
reports (2)
book (2)
doctoral thesis (1)
research review (1)
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book chapter (1)
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Type of content
peer-reviewed (138)
other academic/artistic (42)
Author/Editor
Wikman, A (121)
Edgren, G (17)
Tiblad, E (17)
Westgren, M (16)
Hoglund, P (14)
Agren, A (13)
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Ostlund, A (13)
Gryfelt, G (12)
Lundahl, J (12)
Reilly, M (11)
Nicholls, Ian A. (10)
Wikman, Susanne (10)
Lagergren, P (10)
Wikman, AT (9)
Wikman, Anna (9)
Lozano, M (7)
Andersson, Håkan S. (7)
Karlsson, A. (7)
Sandgren, P (7)
Meinke, S (7)
Delaney, M (7)
Uhlin, M. (6)
Ajne, G (6)
Henschel, Henning (6)
Alexanderson, K (5)
Watz, E. (5)
Ståhl, Stefan (5)
Requena-Méndez, A (5)
Lindqvist, PG (5)
Hjalgrim, H (5)
Johar, MA (5)
Steptoe, A (5)
Rostgaard, K (5)
Murphy, MF (5)
Yazer, MH (5)
Kutner, JM (5)
Savoia, H (5)
Jacobson, SH (4)
Remberger, M. (4)
Mattsson, J. (4)
Hesselman, Susanne, ... (4)
Johar, A (4)
Wikman, Maria (4)
Wahlgren, CM (4)
Muniz-Diaz, E (4)
Bruun, MT (4)
Titlestad, K (4)
Pierelli, L (4)
Karlsson, Björn C. G ... (4)
Rosengren, Annika M. (4)
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University
Karolinska Institutet (147)
Uppsala University (18)
Royal Institute of Technology (10)
Linnaeus University (9)
Lund University (6)
Luleå University of Technology (5)
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Umeå University (4)
University of Gothenburg (3)
Linköping University (3)
Stockholm University (2)
Malmö University (2)
Halmstad University (1)
Karlstad University (1)
Swedish University of Agricultural Sciences (1)
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Language
English (178)
Swedish (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (29)
Natural sciences (15)
Social Sciences (6)
Engineering and Technology (3)
Humanities (2)

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