1. |
- Aad, G, et al.
(author)
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- 2015
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swepub:Mat__t
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6. |
- Arndt, D. S., et al.
(author)
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STATE OF THE CLIMATE IN 2017
- 2018
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In: Bulletin of The American Meteorological Society - (BAMS). - : American Meteorological Society. - 0003-0007 .- 1520-0477. ; 99:8, s. S1-S310
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Research review (peer-reviewed)
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7. |
- Abbafati, Cristiana, et al.
(author)
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- 2020
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Journal article (peer-reviewed)
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9. |
- Cespedes, PF, et al.
(author)
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T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles
- 2022
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 3460-
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Journal article (peer-reviewed)abstract
- The immunological synapse is a molecular hub that facilitates the delivery of three activation signals, namely antigen, costimulation/corepression and cytokines, from antigen-presenting cells (APC) to T cells. T cells release a fourth class of signaling entities, trans-synaptic vesicles (tSV), to mediate bidirectional communication. Here we present bead-supported lipid bilayers (BSLB) as versatile synthetic APCs to capture, characterize and advance the understanding of tSV biogenesis. Specifically, the integration of juxtacrine signals, such as CD40 and antigen, results in the adaptive tailoring and release of tSV, which differ in size, yields and immune receptor cargo compared with steadily released extracellular vesicles (EVs). Focusing on CD40L+tSV as model effectors, we show that PD-L1 trans-presentation together with TSG101, ADAM10 and CD81 are key in determining CD40L vesicular release. Lastly, we find greater RNA-binding protein and microRNA content in tSV compared with EVs, supporting the specialized role of tSV as intercellular messengers.
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10. |
- York, A. M., et al.
(author)
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Household bottled water consumption in Phoneix : a lifestyle choice
- 2011
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In: Water international. - : Informa UK Limited. - 0250-8060 .- 1941-1707. ; 36:6, s. 708-718
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Journal article (peer-reviewed)abstract
- The demand for bottled water has grown tremendously in recent years, together with concern about its environmental impacts. The authors surveyed individuals in Phoenix, Arizona about their water consumption behaviour, socio-demographic characteristics, perception of water quality and trust in the government's willingness to respond to water quality issues. Using a logit model, the authors then tested the relationship between the respondents' characteristics and bottled water consumption for cooking and drinking in the home. Our results indicate that bottled water consumption reflects lifestyle choice not environmental concerns.
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