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- Åström, Mattias, et al.
(författare)
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Method for patient-specific finite element modeling and simulation of deep brain stimulation
- 2009
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Ingår i: Medical and Biological Engineering and Computing. - : Springer. - 0140-0118 .- 1741-0444. ; 47:1, s. 21-28
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Tidskriftsartikel (refereegranskat)abstract
- Deep brain stimulation (DBS) is an established treatment for Parkinsons disease. Success of DBS is highly dependent on electrode location and electrical parameter settings. The aim of this study was to develop a general method for setting up patient-specific 3D computer models of DBS, based on magnetic resonance images, and to demonstrate the use of such models for assessing the position of the electrode contacts and the distribution of the electric field in relation to individual patient anatomy. A software tool was developed for creating finite element DBS-models. The electric field generated by DBS was simulated in one patient and the result was visualized with isolevels and glyphs. The result was evaluated and it corresponded well with reported effects and side effects of stimulation. It was demonstrated that patient-specific finite element models and simulations of DBS can be useful for increasing the understanding of the clinical outcome of DBS.
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- Åström, Mattias, et al.
(författare)
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Patient-specific models and simulations of deep brain stimulation for postoperative follow-up
- 2009
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Ingår i: World Congress on Medical Physics and Biomedical Engineering. - Berlin, Heidelberg : Springer. - 9783642038884 - 9783642038891 ; , s. 331-334
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Konferensbidrag (refereegranskat)abstract
- Deep brain stimulation (DBS) is an established treatment for Parkinson’s disease (PD). The success of DBS is highly dependent on electrode location and electrical parameter settings. In this study patient-specific computer models of DBS were used for postoperative follow-up in three PD patients who suffered from stimulation induced hypomania, dysarthria, and uncontrollable laughter respectively. The overall aim of the study was to relate the anatomical aspect of the electric field to the effects and side effects of stimulation. The simulations showed the anatomical distribution of the electric field for all the patients and the results were in agreement with previous reports regarding these side effects of stimulation. It was demonstrated that patient-specific models and simulations of DBS may be useful for postoperative follow-up of DBS.
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