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- Li, Yanying, et al.
(författare)
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A D-peptide ligand of neuropeptide Y receptor Y-1 serves as nanocarrier traversing of the blood brain barrier and targets glioma
- 2022
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Ingår i: Nano Today. - : Elsevier. - 1748-0132 .- 1878-044X. ; 44
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Tidskriftsartikel (refereegranskat)abstract
- Diseases of the central nervous system (CNS) are challenging for drug treatment because the blood-brain barrier (BBB) restricts entry of drugs into the brain tissue. Therefore, strategies for drug transport across the BBB are an important component in development of CNS drug therapies. Here, a D-amino acid ligand of the neuropeptide Y (NPY) receptor Y1 is described, (D)[Asn(28), Pro(30), Trp(32)]-DNPY (25-36) (termed DAPT), with 2.5 times higher number of hydrogen bonds interacting with the receptor, based on docking into a structural model, than the corresponding peptide with standard L-amino acids (LAPT). Using in vitro BBB models, in vivo healthy mice with intact BBB, and U87-MG orthotopic tumor-bearing mice, we demonstrate that DAPT exhibits significantly higher ability than LAPT to serve as nanocarrier across the BBB and specifically targets gliomas. Using DAPT nanomicelles loaded with IRDye780, it was possible to achieve excellent photothermal therapeutic and photoacoustic cancer imaging. Thus, this study demonstrates the importance of ligand stability and affinity in Y1 receptor-mediated transcytosis and paves the way for versatile brain tumor imaging and therapy using nanomicelles.
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- Losch, Pit, et al.
(författare)
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Colloidal nanocrystals for heterogeneous catalysis
- 2019
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Ingår i: Nano Today. - : Elsevier. - 1748-0132 .- 1878-044X. ; 24, s. 15-47
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Tidskriftsartikel (refereegranskat)abstract
- Catalytic materials are an essential component of the chemical industry. They find applications in everything from fine chemical manufacturing to greenhouse gas mitigation. They are indispensable for developing a sustainable future. Their development has been continuous, from early trial and error efforts to the first fundamental insights gained through surface science, to modern in-situ characterization and computational predictions. The accumulation of knowledge on the working principles of catalytic surfaces allowed designing and producing better systems with improved performance. Even though tremendous progress has been made thanks to surface science techniques, these studies are usually performed under ultra-high vacuum and are therefore limited in their applicability to more relevant industrial conditions. The control over size, shape and composition in colloidal nanocrystals makes them formidable precursors for model heterogeneous catalysts. These model systems enable linking the insights from surface science studies via in-situ and operando studies to realistic catalytic reaction conditions. In this review, colloidal nanocrystals are presented as powerful building blocks for catalytic materials in the quest for fundamental understanding. A review of the principal methods to produce colloidal nanocrystals with a high level of control is reported, complemented by procedures for how to prepare active catalysts from these particles. Examples and guidelines for the catalytic applications of these materials revolve around the three guiding objectives in catalysis science: activity, selectivity and stability. This work will be limited to examples of this colloidal approach in the areas of thermal, electro- and photocatalysis. The exposed approaches can be used and extended to many other areas of catalysis science, thus providing a new avenue to explore fundamentals and applications of catalytic materials.
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| 10. |
- Otnes, Gaute, et al.
(författare)
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Towards high efficiency nanowire solar cells
- 2017
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Ingår i: Nano Today. - : Elsevier BV. - 1748-0132. ; 12, s. 31-45
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Tidskriftsartikel (refereegranskat)abstract
- Semiconductor nanowires are a class of materials recently gaining increasing interest for solar cell applications. In this article we review the development of the field with a special focus on the III-V materials due to their potential to reach high power conversion efficiencies. After introducing basic concepts of nanowire synthesis, we discuss important aspects of nanowire design for high power conversion efficiencies; first in terms of light absorption, then in terms of charge carrier separation and collection. Further, we examine methods to assess and understand the materials quality and the solar cell performance. We end the review by a discussion of strategies and challenges in achieving efficiencies above the Shockley-Queisser limit, and the potential for cost efficient production.
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| 11. |
- Perivoliotis, Dimitrios K., et al.
(författare)
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Recent progress on defect-rich electrocatalysts for hydrogen and oxygen evolution reactions
- 2023
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Ingår i: Nano Today. - : Elsevier. - 1748-0132 .- 1878-044X. ; 50
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Forskningsöversikt (refereegranskat)abstract
- To meet the demanding requirements for clean energy production, the need to develop advanced electrocatalysts for efficiently catalysing the water splitting reactions attracts a continuously increased attention. However, to meet the anticipated expansion in green hydrogen production from renewable energy sources, the catalysts used for the water splitting reaction not only need to satisfy the required figures of merit but should concurrently be based mainly on abundant, non-critical materials with low environmental impact. In last decades, non-noble metal catalysts, based on transition metals, rare-earth metals, dichalcogenides, and light elements such as phosphorus, nitrogen, and sulphur have shown improved performance. Moreover, in recent years increased interest has been focused on variations of such materials, more specifically on the introduction of defects to further boost their catalytic performance. Through the many studies performed over the last years, it is now possible to summarize, understand and describe the role of these defects for the water splitting reactions, namely the hydrogen and oxygen evolution reactions, and thereby to suggest strategies in the development of next generation electrocatalysts. This is the goal of the current review; we critically summarize the latest progress on the role of introduced defects for catalytic electrolysis applications by scrutinizing the structure–performance correlation as well as the specific catalytic activity. A broad class of nanomaterials is covered, comprising transition metal dichalcogenides, transition metal oxides and carbides, carbon-based materials as well as metal–organic frameworks (MOFs). Finally, the main challenges and future strategies and perspectives in this rapidly evolving field are provided at the end of the review.
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| 12. |
- Schönborn, Konrad, et al.
(författare)
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Nano education with interactive visualization
- 2016
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Ingår i: Nano Today. - : Elsevier. - 1748-0132 .- 1878-044X. ; 11:5, s. 543-546
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Tidskriftsartikel (refereegranskat)abstract
- Future societal and economic impacts of nanoscience and nanotechnology raise the demand for a nano-literate public as well as a nano-competent workforce. This translates into the urgent need for nano education interventions in schools and informal learning contexts. In seeking to meet this mandate, we have developed and investigated a virtual reality environment that induces immersive presence (feeling as being ‘in’ the virtual world) and exploits bodily movements (e.g. hand gestures to control virtual objects) for students and citizens to learn nano concepts. In this article, we argue that such scientifically-informed immersive and interactive visualizations have a unique potential in communicating nanoscale ideas to students as well as the general public.
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| 13. |
- Xu, Wen, et al.
(författare)
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Localized surface plasmon resonances in self-doped copper chalcogenide binary nanocrystals and their emerging applications
- 2020
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Ingår i: Nano Today. - : Elsevier BV. - 1748-0132 .- 1878-044X. ; 33, s. 100892-
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Forskningsöversikt (refereegranskat)abstract
- Owing to their extraordinary surface plasmon and semiconductor properties, copper chalcogenide nanocrystals (NCs) have experienced a steeply increased interest for various types of applications since the first discovery of their plasmonic property in 2009. This article critically and comprehensively reviews the decade long research effort devoted to doped plasmonic copper chalcogenide binary NCs with respect to their synthesis methods, their theoretical description and various applications. In particular, we focus on factors that impact their localized surface plasmon resonances (LSPRs) and on methods used for tuning the LSPRs. We emphasize the underlying mechanisms of LSPR generation and the unique roles and advantages of the copper chalcogenide NCs with respect to the commonly attended plasmonic metal nanoparticles. Finally, we review current challenges in the field of copper chalcogenide NCs and give a perspective for further research. We believe that this review provides a timely and concise summary of the field of plasmonic copper chalcogenide NCs for the benefit and inspiration of its rapid and formulated development.
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| 14. |
- Yang, Zhongwei, et al.
(författare)
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Application of bismuth sulfide based nanomaterials in cancer diagnosis and treatment
- 2023
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Ingår i: Nano Today. - : Elsevier BV. - 1878-044X .- 1748-0132. ; 49
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Forskningsöversikt (refereegranskat)abstract
- Cancer is still the leading disease threatening human life and health at present. With the development of nanotechnology, multifunctional nanomaterials integrated with different diagnostic and therapeutic functions have become the most active field in nano-research. Among them, Bi2S3-based nanomaterials have attracted great attention in the biomedical field due to their special photothermal effect and biocompatibility. In this review, we systematically summarize the synthetic strategies and their physical-chemical properties of Bi2S3-based nanomaterials. Then we outline the recent research progress in the diagnosis and treatment of cancer, which are highlighted and discussed in detail. In addition, the safety and biodistribution of Bi2S3-based nanomaterials are emphasized and discussed. It is believed that the emerging Bi2S3-based nanomaterials may realize the practical applications via unremitting efforts of scientific researchers in the near future.
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| 15. |
- Ye, Fei, et al.
(författare)
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Advances in nanotechnology for cancer biomarkers
- 2018
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Ingår i: Nano Today. - : Elsevier. - 1748-0132 .- 1878-044X. ; 18, s. 103-123
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Tidskriftsartikel (refereegranskat)abstract
- Cancer biomarkers with high selectivity, specificity and reproducibility play essential role in diagnosis, prognosis and prediction of treatment efficacy in cancer patients. However, the current biomarker assays used in clinics could be improved due to low sensitivity and specificity. Nanoparticle-based assays are emerging as an upcoming approach, providing ultra-high sensitivity and specificity in cancer biomarker detection. The current survey presents an overview of strategies used in the development and integration of nanoparticles for cancer biomarker detection, including mass spectrometry, optical and electrical detection methods. Moreover, we discuss the future trends in the field in correlation to new approaches from fundamental and practical standpoints.
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| 17. |
- Zhang, Ye, et al.
(författare)
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Application of graphdiyne oxide in photoelectrochemical-type photodetectors and ultrafast fiber lasers
- 2022
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Ingår i: Nano Today. - : Elsevier. - 1748-0132 .- 1878-044X. ; 47
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Tidskriftsartikel (refereegranskat)abstract
- Graphdiyne oxide (GDYO), the oxidized form of graphdiyne (GDY), has been widely explored for applica-tions in various technological fields owing to its fascinating properties. However, the research of GDYO for applications in photodetectors (PDs) and mode-locker has been lagging. Herein, we present experimental demonstrations of promising applications of GDYO for narrow-band photoelectrochemical (PEC)-type PDs with tunable performance. Moreover, the measured excellent nonlinear optical absorption of GDYO makes it a suitable material for mode-locking in ultrafast fiber lasers. Ultrastable pulses as short as 1.5 ps could be obtained from an Erbium-doped fiber laser based on GDYO at 1559 nm. These findings have been supported and interpreted by density functional theory (DFT) calculations as well as transient absorption dynamics studies. The presented results provide pathways for the future utilization of GDYO in high-performance optoelectronic devices.
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| 18. |
- Zhao, Yiming, et al.
(författare)
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Fabrication of lead telluride quantum dots and their application in photoelectrochemical-type photodetectors
- 2023
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Ingår i: Nano Today. - : ELSEVIER SCI LTD. - 1748-0132 .- 1878-044X. ; 52
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Tidskriftsartikel (refereegranskat)abstract
- IV-VI semiconductors have been extensively applied in photo-electrochemical (PEC)-type photodetectors. However, electrolytes with relatively high concentrations have been addressed which could induce electro-chemical reactions during the measurement and result in a performance decrement. In this work, lead telluride quantum dots (PbTe QDs) with uniform size distribution are fabricated for PEC-type photodetectors and their performance is systematically investigated in electrolytes with concentrations as low as 10-4 mol/L. As revealed, the PbTe QD-based photodetectors show apparent photo-response with excellent stability in 1000 cycles (decrement of 0.018 % per cycle). In addition, the as-fabricated photodetectors show a broadband response to light in a region of 350-700 nm. These results are well supported by density functional theory calculations based on structural features and electronic and optical properties. Hence, we envisage that this work paves the way to fabricate high-performance photodetectors in relatively low-concentration electrolytes, which also can extend their applications to other optoelectronic devices.
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