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| 3. |
- Balldin, J, et al.
(author)
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A 6-month controlled naltrexone study: Combined effect with cognitive behavioral therapy in outpatient treatment of alcohol dependence
- 2003
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In: Alcoholism: Clinical and Experimental Research. - 0145-6008 .- 1530-0277. ; 11
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Journal article (peer-reviewed)abstract
- Background: In several studies, patients with alcohol dependence treated with the opioid antagonist naltrexone have shown fewer relapses to heavy drinking than those receiving placebo. An interaction between the naltrexone effect and the type of psychological therapy has been observed. Methods: A 6-month, double-blind, placebo-controlled, parallel-group study was performed at 10 different investigation sites. After a placebo run-in period of 1 week, 118 patients were randomized into 4 treatment groups—50 mg of naltrexone daily or placebo in combination with either cognitive behavioral therapy (CBT) or supportive therapy. The CBT was performed over nine sessions according to the manual of Project MATCH (Matching Alcoholism Treatments to Client Heterogeneity). The supportive therapy was defined as "the treatment as usual." Alcohol consumption, craving, carbohydrate-deficient transferrin, medication compliance by tablet count, and adverse clinical events were assessed at all visits. Other liver enzymes and psychiatric symptoms were also determined. Results: Ninety-one (77%) patients completed the study, and 92 (78%) were 80% compliant with the medication regimen. A lower percentage of heavy-drinking days was shown in the naltrexone group (p = 0.045) compared with the placebo group, as was a lower craving score (p = 0.029). These results are supported by the lower levels of liver enzyme activities (p < 0.010 for aspartate aminotransferase, alanine aminotransferase, and γ-glutamyltransferase), but not by the carbohydrate-deficient transferrin levels, in the naltrexone group. The mean time period before the first day of heavy drinking was longer for the group treated with CBT (p = 0.010), especially in combination with naltrexone (p = 0.007). Naltrexone was well tolerated, and no patients discontinued the study due to side effects. Conclusions: This study supports the effect of naltrexone in outpatient treatment of alcohol dependence and suggests that a beneficial interaction effect with CBT can be expected.
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| 4. |
- Berglund, Anders, 1974-
(author)
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Two facets of Innovation in Engineering Education : The interplay of Student Learning and Curricula Design
- 2013
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Doctoral thesis (other academic/artistic)abstract
- This thesis covers two main perspectives ofinnovation; first, innovation is regarded as an outcome-related mechanism wherelearning is expressed through artefact presentations at the end of adevelopment process; second, innovation comprises a change mechanism in theprocess of student learning, influencing educators to reconsider new methods andpractices. Building on qualitative data from engineering design courses, theaim has been to explore how learning elements in engineering educationinfluence students during early-phase innovation. By implementing andpracticing learning elements, early-phase innovation could strengthen both currentand future engineering curricula, courses, and programmes.This thesis put attention to authentic experiences in which learning elementsis acted upon by students and targeted, defined, and refined by educators.Introducing learning elements need educators to manifest learning efforts moreexplicitly to match students’ capability to interpret new knowledge. Adoptinglearning elements that challenge existing paths of action are characterized by diversity, proactivity, opennessand motivation. For students to excel in the exploration of early-phaseinnovation, it is important to identify when, how and to what extent leaningelements can be reinforced. Thestrengthened understanding by students is mirrored in improved ability to takeaction and apply relevant knowledge in distinct learning situations. Theopportunity to influence student learning provides the design and redesign of curricula,courses and programmes as a prime feature to leaning elements relevant to early-phaseinnovation. To successfully pursue innovation in engineering education abalance is necessary between responsible actors integrating learning elementsand by those determined to learn.
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| 9. |
- Brunnberg, Elinor, 1948-, et al.
(author)
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Hard-of-hearing adolescents reporting some other disability or tinnitus : a replication study including an age-related analysis
- 2009
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Conference paper (other academic/artistic)abstract
- In two previous studies based on the survey, Life & Health Young 2005 in Örebro county 15-16 years old Hard-of-hearing (HH) students with some other disability (HHDIS) and HH with tinnitus (HHTINN) reported considerably higher scores for mental symptoms and substance use than adolescents ‘just‘ HH or hearing adolescents. In order to replicate these findings we analysed the 2007 survey and included adolescents in grade 7, 9 and 2 in secondary school concerning substance use and depression. We also used reference data from the corresponding adult survey Life & Health 2008. In grade 9 HHDIS (2.0%) and HHTINN (2.0 %) both reported strongly increased rates of risky alcohol consumption (55/51% versus 13%), daily tobacco use (57/54% versus 10%) and depression (43/43% versus 14%) than hearing or ´just´ HH adolescents. Similar but less pronounced changes were present in grade 7 and grade 2. In HHDIS increased risk drinking was found until age 35, increased daily tobacco use until age 50 and increased depression until age 65. In HHTINN only rate of depression was increased in adult life. HHDIS and HHTINN thus are important targets for preventive measures. In addition tinnitus in young people can be a marker like disability of vulnerability.
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| 10. |
- Brunnberg, Elinor, et al.
(author)
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School adjustment, mental symptoms and substance use in 16 year old students with hearing impairment and other disabilities
- 2007
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Conference paper (peer-reviewed)abstract
- There are few studies on substance use, mental symptoms and school problems in adolescents with multi-disabilities. This survey, “Life and health-young 2005”, included all children in mainstream schools class 9 in the county of Örebro, Sweden. Children attending special schools for deaf/hard-of-hearing and multi-disabled children were not included. There were 56 (1.9%) hard-of-hearing students with some other disability, 93 (3.1%) ‘just hard-of-hearing’ students, 282 (9.7%) students with some other disability than hearing impairment and 2488 (85.2%) without a disability. Hard-of-hearing/other disability group of students reported considerably higher scores on mental symptoms, substance use and school problems than the others. A logistic regression analysis showed that mental symptoms explained 17% of the variance, alcohol and drugs 15% and school problems 9%. The final model explained 24% and included use of illegal drugs (OR 8.3), often irritated (OR 4.2), feeling bad (OR 3.2) and bullied (OR 2.2). In the hard-of-hearing/other disability group 43% reported at least 2 of these symptoms and in the other groups 17%, 18% and 8%, respectively. The combination of hearing impairment and other disabilities increases the risk for mental symptoms, substance use and school problems. This group of students in mainstream schools ought to be an important target for preventive efforts.
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| 11. |
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| 12. |
- Brunnberg, Elinor, 1948-, et al.
(author)
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Self-rated mental health, school adjustment, and substance use in hard-of-hearing adolescents
- 2008
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In: Journal of Deaf Studies and Deaf Education. - : Oxford University Press (OUP). - 1081-4159 .- 1465-7325. ; 13:3, s. 324-335
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Journal article (peer-reviewed)abstract
- This survey, "Life and Health—Young People 2005," included all 15/16-year-old adolescents in mainstream schools in the county of Örebro, Sweden. Just students with a slight/mild or moderate hearing loss were included. There were 56 (1.9%) "hard-of-hearing (HH) students with multiple disabilities," 93 (3.1%) students who were "just HH," 282 (9.7%) students with some "other disability than HH," and 2,488 (85.2%) students with "no disability." "HH with multiple disabilities" reported considerably higher scores for mental symptoms, substance use, and school problems than the "no disability" group. Those with "just HH" and those with "other disability than HH" had more mental symptoms and school problems than the "no disability" group but no significant differences in substance use. In conclusion, the combination of a hearing loss and some other disability strongly increases the risk for mental symptoms, school problems, and substance use. This group, thus, is an important target for preventive measures.
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| 13. |
- Brunnberg, Elinor, 1948-, et al.
(author)
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Sexual force at sexual debut. Swedish adolescents with disabilities at higher risk than adolescents without disabilities
- 2012
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In: Child Abuse & Neglect. - : Elsevier BV. - 1873-7757 .- 0145-2134. ; 36:4, s. 285-295
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Journal article (peer-reviewed)abstract
- The aims of this study are first to compare the incidence of force on the first occasion of sexual intercourse reported by participants with disabilities to that of students without disabilities; second to determine whether there are significant differences in mental health, substance abuse, and school performance as reported by participants forced into their sexual debut as opposed to those who were not forced, analysed by gender; and finally to identify the significant variables that predict girls reporting force at sexual debut as opposed to girls not reporting force, as well as to identify similar variables within the male group. There were no data on sexual abuse prior to the first occasion of full sexual intercourse. Method: This cross-sectional study is based on 2 surveys: Life and Health Young People 2005 and 2007. All 17/18-year-old adolescents in upper-secondary schools in a county in Sweden were asked the same questions both years. A total of 2,254 students completed the survey in 2005 and 2,641 in 2007. Results: The main finding is that force at sexual debut (intercourse) is more common among adolescents with a disability (4.0%) than those not reporting any disability (1.6%), and is most common among those reporting multiple disabilities (10.4%). This was found both for girls and boys, even if the rates for girls were several times higher. Other findings are that girls and boys reporting force at sexual debut (disability and non-disability groups taken together) reported different profiles. For girls, their country of origin and who they live with are significant. This background data is not significant for boys. Boys report a strong psychosomatic reaction. Conclusion: Culture-, functionality-, and gender-sensitive studies of adolescents' reactions to sexual abuse are needed to help determine relevant and effective interventions (C) 2012 Elsevier Ltd. All rights reserved.
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| 14. |
- Brunnberg, Elinor, 1948-, et al.
(author)
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Sexuality of 15/16-year-old girls and boys with and without modest disabilities
- 2009
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In: Sexuality and disability. - : Springer. - 0146-1044 .- 1573-6717. ; 27:3, s. 139-153
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Journal article (peer-reviewed)abstract
- Girls and boys with disabilities, 15-16 years of age, report a significantly higher rate of sexual debut than adolescents with no disabilities. In a society where a young person with a disability often is considered to have an essentially asexual status, there can be several fronts for adolescents to fight. The survey Life and Health - Young People 2005 was completed by 3,084 adolescents attending mainstream schools in Sweden. In this study the sexual debut in girls and boys with and without disabilities is related to mental health, school exposure and substance use. Our findings might be explained by a mechanism of identity construction from the adolescents' ideas of normality and by a battle for acceptance and confirmation of life. The ideas of normality can be erroneous but still influence the adolescents' sexual activity. Multivariate analyses also showed that the relationship between sex and substance use is strong among all adolescents.
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| 15. |
- Brunnberg, Elinor, et al.
(author)
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Tinnitus and hearing loss in 15-16-year-old students : mental health symptoms, substance use, and exposure in school
- 2008
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In: International Journal of Audiology. - : Informa UK Limited. - 1499-2027 .- 1708-8186. ; 47:11, s. 688-694
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Journal article (peer-reviewed)abstract
- The current study assessed the responses from a survey titled ”Life and Health – Young People 2005”, completed by 2.878 15-16 year-old adolescents in mainstream schools in the county of Örebro, Sweden. Thirty-nine percent of students with hearing loss (slight, mild, or moderate) and 6% of students with normal hearing reported tinnitus often or always during the past three months. Almost no gender difference was observed among students with normal hearing reporting tinnitus (boys 6.3%, girls 5.6%); however, a gender difference was noticed among hard-of-hearing (HH) students (boys 50%, girls 28%). Adolescents with both hearing loss and tinnitus reported considerably higher scores for mental symptoms, substance use, and school problems than other students. Anxiety in the past three months, male gender, and alcohol consumption in the past year were associated with tinnitus in HH students; irritation and anxiety in the past three months, disability, use of illicit drugs, and truancy predicted tinnitus in the normal hearing group. Consequently, students with a hearing loss and tinnitus are at high risk and should be monitored for subsequent problems.
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| 16. |
- Dijken, Jan W.V. van, 1947-, et al.
(author)
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Samarbete breddar forskning : Oral Biomaterialgruppen, Umeå
- 2008
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In: Tandläkartidningen. - : Sveriges Tandläkarförbund. ; 100:5, s. 74-79
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Journal article (pop. science, debate, etc.)abstract
- Vid institutionen för odontologi vid Umeå Universitet finns en lång tradition av biomaterialforskning. För drygt två år sedan samlades större delen av den forskningen i ett vetenskapligt nätverk. Här beskrivs ett axplock av det breda forskningsarbetet.
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| 17. |
- Djahedi, Cyrus, 1985-
(author)
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Deformation of cellulose allomorphs studied by molecular dynamics
- 2015
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Licentiate thesis (other academic/artistic)abstract
- Cellulose-based materials draw their good mechanical properties from the cellu-lose crystal. Improved understanding of crystal properties could lead to a wider range of applications for cellulose-based materials, Cellulose crystals show high axial Youngs modulus. Cellulose can attain several allomorphic forms which show unique structural arrangements in terms of both intra-molecular and inter-molecular bonding, as well as unit cell parameters and chain packing. Although several studies have confirmed that mechanical tensile properties of cellulose differ between different allomorphic forms, few reports have investigated the deformation mechanisms explaining the differences.In the first part of this thesis, the tensile elastic Youngs modulus of cellulose allo-morphs Iβ, II and III I were calculated under uniform conditions using Molecular Dynamics simulation techniques. As expected, a difference in modulus valuesc ould be observed, and the cooperative nature of energy contributions to crys-tal modulus is apparent. The allomorphs also show large differences in terms of how contributions to elastic energy are distributed between covalent bonds,angles, dihedrals, electrostatic forces, dispersion and steric forces.In the second part of this thesis, the cellulose Iβ and II allomorphs were sub-jected to a more detailed structural study. The purpose was to clarify how the deformation of the central glucosidic linkage between the monomer units depends on the hydrogen-bonding structures. This was carried out by studying simulated vibrational spectra and local deformations in the crystals.The results presented in this thesis confirm the differences in the tensile elastic properties of these cellulose allomorphs. These differences can in part be explained by the different intra-molecular hydrogen bonding patterns between allomorphs. Deformation mechanisms are discussed. The results are in supportof the so called ”leverage effect” proposed in the literature. The present analysis shows significant differences in details of deformation mechanisms compared with previous simpler analyses.
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| 18. |
- Drevin, Jennifer, et al.
(author)
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Adverse childhood experiences influence development of pain during pregnancy.
- 2015
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In: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 0001-6349 .- 1600-0412. ; 94:8, s. 840-846
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Journal article (peer-reviewed)abstract
- OBJECTIVE: To investigate the association between adverse childhood experiences (ACE) and pain with onset during pregnancy.DESIGN: Cross-sectional study.SETTING: Eighteen antenatal clinics in southern Mid-Sweden.SAMPLE: Of 293 women invited to participate, 232 (79%) women agreed to participate in early pregnancy and were assessed in late pregnancy.METHODS: Questionnaires were distributed in early and late pregnancy. The questionnaires sought information on socio-demography, ACE, pain location by pain drawing and pain intensity by visual analogue scales. Distribution of pain was coded in 41 predetermined areas.MAIN OUTCOME MEASURES: Pain in third trimester with onset during present pregnancy: intensity, location and number of pain locations.RESULTS: In late pregnancy, 62% of the women reported any ACE and 72% reported any pain location with onset during the present pregnancy. Among women reporting any ACE the median pain intensity was higher compared with women without such an experience (p = 0.01). The accumulated ACE displayed a positive association with the number of reported pain locations in late pregnancy (rs = 0.19, p = 0.02). This association remained significant after adjusting for background factors in multiple regression analysis (p = 0.01). When ACE was dichotomized the prevalence of pain did not differ between women with and without ACE. The subgroup of women reporting physical abuse as a child reported a higher prevalence of sacral and pelvic pain (p = 0.0003 and p = 0.02, respectively).CONCLUSIONS: Adverse childhood experiences were associated with higher pain intensities and larger pain distributions in late pregnancy, which are risk factors for transition to chronic pain postpartum.
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| 23. |
- Hagerman, Inger, et al.
(author)
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Effects on heart rate variability by artificially generated indoor nano-sized particles in a chamber study
- 2014
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In: Atmospheric Environment. - : Elsevier BV. - 1352-2310. ; 88, s. 165-171
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Journal article (peer-reviewed)abstract
- Background: Airborne particles are associated with increased morbidity and mortality due to respiratory and cardiovascular diseases in polluted areas. There is a growing interest in nano-sized particles with diameter < 100 nm and their potential health effects. Heart rate variability (HRV) is a noninvasive method for cardiovascular risk prediction in high prevalent groups. Aim of study: The aim was to evaluate the impact of nano-sized indoor air particles on HRV for healthy and adult females. Methods: All exposures were performed as controlled chamber experiments with particle exposure from burning candles, terpene + ozone reactions or filtered air in a double-blind cross over design. Twenty-two healthy females were investigated during 10 min periods at different exposures and the reactivity in high frequency (HF) spectral band of HRV were computed. Results: Heart rate was unchanged from baseline values in all groups during all experimental settings. HF power of HRV tended to increase during exposure to particles from burning candle while particles from terpene + ozone reactions tended to decrease HF power. Conclusions: Exposure to nano-sized particles of burning candles or terpene + ozone reactions results in different patterns of heart rate variability, with signs of altered autonomic cardiovascular control. Practical implications: This study indicates that the HRV method may be used for information on physiological responses of exposure to different nano-sized particles and contribute to the understanding of mechanisms behind health effects of particle exposures. (C) 2014 The Authors. Published by Elsevier Ltd.
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