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- Basso, L, et al.
(author)
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Sex Differences in Comorbidity Combinations in the Swedish Population
- 2022
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In: Biomolecules. - : MDPI AG. - 2218-273X. ; 12:7
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Journal article (peer-reviewed)abstract
- High comorbidity rates, especially mental–physical comorbidity, constitute an increasing health care burden, with women and men being differentially affected. To gain an overview of comorbidity rates stratified by sex across a range of different conditions, this study examines comorbidity patterns within and between cardiovascular, pulmonary, skin, endocrine, digestive, urogenital, musculoskeletal, neurological diseases, and psychiatric conditions. Self-report data from the LifeGene cohort of 31,825 participants from the general Swedish population (62.5% female, 18–84 years) were analyzed. Pairwise comorbidity rates of 54 self-reported conditions in women and men and adjusted odds ratios (ORs) for their comparison were calculated. Overall, the rate of pairwise disease combinations with significant comorbidity was higher in women than men (14.36% vs. 9.40%). Among psychiatric conditions, this rate was considerably high, with 41.76% in women and 39.01% in men. The highest percentages of elevated mental–physical comorbidity in women were found for musculoskeletal diseases (21.43%), digestive diseases (20.71%), and skin diseases (13.39%); in men, for musculoskeletal diseases (14.29%), neurological diseases (11.22%), and digestive diseases (10%). Implications include the need for integrating mental and physical health care services and a shift from a disease-centered to an individualized, patient-centered focus in clinical care.
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- Cederroth, CR, et al.
(author)
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A New Buzz for Tinnitus-It's in the Genes!
- 2020
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In: JAMA otolaryngology-- head & neck surgery. - : American Medical Association (AMA). - 2168-619X .- 2168-6181. ; 146:11, s. 1025-1026
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Journal article (peer-reviewed)
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- Cederroth, CR, et al.
(author)
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An update: emerging drugs for tinnitus
- 2018
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In: Expert opinion on emerging drugs. - : Informa UK Limited. - 1744-7623 .- 1472-8214. ; 23:4, s. 251-260
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Journal article (peer-reviewed)
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- Cederroth, CR, et al.
(author)
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Association between Hyperacusis and Tinnitus
- 2020
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In: Journal of clinical medicine. - : MDPI AG. - 2077-0383. ; 9:8
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Journal article (peer-reviewed)abstract
- Many individuals with tinnitus report experiencing hyperacusis (enhanced sensitivity to sounds). However, estimates of the association between hyperacusis and tinnitus is lacking. Here, we investigate this relationship in a Swedish study. A total of 3645 participants (1984 with tinnitus and 1661 without tinnitus) were enrolled via LifeGene, a study from the general Swedish population, aged 18–90 years, and provided information on socio-demographic characteristics, as well as presence of hyperacusis and its severity. Tinnitus presence and severity were self-reported or assessed using the Tinnitus Handicap Inventory (THI). Phenotypes of tinnitus with (n = 1388) or without (n = 1044) hyperacusis were also compared. Of 1661 participants without tinnitus, 1098 (66.1%) were women and 563 were men (33.9%), and the mean (SD) age was 45.1 (12.9). Of 1984 participants with tinnitus, 1034 (52.1%) were women and 950 (47.9%) were men, and the mean (SD) age was 47.7 (14.0) years. Hyperacusis was associated with any tinnitus [Odds ratio (OR) 3.51, 95% confidence interval (CI) 2.99–4.13], self-reported severe tinnitus (OR 7.43, 95% CI 5.06–10.9), and THI ≥ 58 (OR 12.1, 95% CI 7.06–20.6). The association with THI ≥ 58 was greater with increasing severity of hyperacusis, the ORs being 8.15 (95% CI 4.68–14.2) for moderate and 77.4 (95% CI 35.0–171.3) for severe hyperacusis. No difference between sexes was observed in the association between hyperacusis and tinnitus. The occurrence of hyperacusis in severe tinnitus is as high as 80%, showing a very tight relationship. Discriminating the pathophysiological mechanisms between the two conditions in cases of severe tinnitus will be challenging, and optimized study designs are necessary to better understand the mechanisms behind the strong relationship between hyperacusis and tinnitus.
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- Cederroth, CR, et al.
(author)
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Medicine in the Fourth Dimension
- 2019
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In: Cell metabolism. - : Elsevier BV. - 1932-7420 .- 1550-4131. ; 30:2, s. 238-250
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Journal article (peer-reviewed)
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- Cederroth, CR
(author)
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Reporting and Sharing Matters
- 2023
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In: Journal of the Association for Research in Otolaryngology : JARO. - 1438-7573. ; 24:5, s. 463-
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Journal article (other academic/artistic)
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| 24. |
- Cederroth, CR
(author)
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Reporting and Sharing Matters
- 2023
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In: Journal of the Association for Research in Otolaryngology : JARO. - 1438-7573. ; 24:5, s. 463-463
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Journal article (other academic/artistic)
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| 25. |
- Cima, RFF, et al.
(author)
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Tinnitus healthcare: a survey revealing extensive variation in opinion and practices across Europe
- 2020
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In: BMJ open. - : BMJ. - 2044-6055. ; 10:1, s. e029346-
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Journal article (peer-reviewed)abstract
- Tinnitus remains a scientific and clinical problem whereby, in spite of increasing knowledge on effective treatment and management for tinnitus, very little impact on clinical practice has been observed. There is evidence that prolonged, obscure and indirect referral trajectories persist in usual tinnitus care.It is widely acknowledged that efforts to change professional practice are more successful if barriers are identified and implementation activities are systematically tailored to the specific determinants of practice. The aim of this study was to administer a health service evaluation survey to scope current practice and knowledge of standards in tinnitus care across Europe. The purpose of this survey was to specifically inform the development process of a European clinical guideline that would be implementable in all European countries.DesignA health service evaluation survey was carried out.SettingThe survey was carried out online across Europe.ParticipantsClinical experts, researchers and policy-makers involved in national tinnitus healthcare and decision-making.Outcome measuresA survey was developed by the study steering group, piloted on clinicians from the TINNET network and underwent two iterations before being finalised. The survey was then administered to clinicians and policy-makers from 24 European countries.ResultsData collected from 625 respondents revealed significant differences in national healthcare structures, use of tinnitus definitions, opinions on characteristics of patients with tinnitus, assessment procedures and particularly in available treatment options. Differences between northern and eastern European countries were most notable.ConclusionsMost European countries do not have national clinical guidelines for the management of tinnitus. Reflective of this, clinical practices in tinnitus healthcare vary dramatically across countries. This equates to inequities of care for people with tinnitus across Europe and an opportunity to introduce standards in the form of a European clinical guideline. This survey has highlighted important barriers and facilitators to the implementation of such a guideline.
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