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1.	Haitjema, S, et al. (author) Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization 2017 In: Circulation. Cardiovascular genetics. - 1942-3268. ; 10:2 Journal article (peer-reviewed)
2.	Leusink, M., et al. (author) Cholesteryl Ester Transfer Protein Polymorphisms, Statin Use, and Their Impact on Cholesterol Levels and Cardiovascular Events 2014 In: Clinical Pharmacology & Therapeutics. - : Springer Science and Business Media LLC. - 0009-9236 .- 1532-6535. ; 95:3, s. 314-320 Journal article (peer-reviewed)abstract The association of nonfunctional variants of the cholesteryl ester transfer protein (CETP) with efficacy of statins has been a subject of debate. We evaluated whether three functional CETP variants influence statin efficacy. The effect of CETP genotype on achieved levels of high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), and total cholesterol during statin treatment was estimated by meta-analysis of the linear regression outcomes of three studies (11,021 individuals). The effect of these single-nucleotide polymorphisms (SNPs) on statin response in protecting against myocardial infarction (MI) was estimated by meta-analysis of statin x SNP interaction terms from logistic regression in five studies (16,570 individuals). The enhancer SNP rs3764261 significantly increased HDLc by 0.02 mmol/l per T allele (P = 6 x 10-5) and reduced protection against MI by statins (interaction odds ratio (OR) = 1.19 per T allele; P = 0.04). Focusing on functional CETP variants, we showed that in carriers of the rs3764261 T variant, HDLc increased more during statin treatment, and protection against MI by statins appeared to be reduced as compared with those in noncarriers.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Doevendans, PAFM (2); Erdmann, J. (1); Bjorkegren, JLM (1); Bis, JC (1); Jukema, JW (1); Simon, T (1); show more...; van der Laan, SW (1); Pasterkamp, G (1); den Ruijter, HM (1); Ridker, P. M. (1); Chasman, D. I. (1); Nyberg, Fredrik, 196 ... (1); Ding, B. (1); Morris, A. D. (1); Palmer, C. N. A. (1); Cheng, C (1); Mokry, M (1); Waltenberger, J (1); Maitland-van der Zee ... (1); van der Harst, P (1); Asselbergs, F. W. (1); de Bakker, P. I. W. (1); Asselbergs, FW (1); Donnelly, L. (1); Tragante, V (1); Danchin, N (1); Asl, HF (1); Onland-Moret, N. C. (1); O'Donnell, C. (1); Hoefer, IE (1); van Setten, J (1); Van Gilst, W. H. (1); Biessen, E (1); Leusink, M (1); Haitjema, S (1); Meddens, CA (1); Kofink, D (1); Harakalova, M (1); Brandt, MM (1); Nieuwenhuis, EES (1); Kotti, S (1); Klungel, O. H. (1); de Boer, A. (1); van Zuydam, N. R. (1); Papp, A. C. (1); Sadee, W. (1); Verstuyft, C. (1); show less...

University: University of Gothenburg (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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