| 1. |
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| 2. |
- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 3. |
- Ablikim, M., et al.
(författare)
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Amplitude analysis of the pi(0)pi(0) system produced in radiative J/psi decays
- 2015
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 92:5
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Tidskriftsartikel (refereegranskat)abstract
- An amplitude analysis of the pi(0)pi(0) system produced in radiative J/psi decays is presented. In particular, a piecewise function that describes the dynamics of the pi(0)pi(0) system is determined as a function of M pi(0)pi(0) from an analysis of the (1.311 +/- 0.011) x 10(9) J/psi decays collected by the BESIII detector. The goal of this analysis is to provide a description of the scalar and tensor components of the pi(0)pi(0) system while making minimal assumptions about the properties or number of poles in the amplitude. Such a model-independent description allows one to integrate these results with other related results from complementary reactions in the development of phenomenological models, which can then be used to directly fit experimental data to obtain parameters of interest. The branching fraction of J/psi -> pi(0)pi(0) is determined to be (1.15 +/- 0.05) x 10(-3), where the uncertainty is systematic only and the statistical uncertainty is negligible.
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| 4. |
- Ablikim, M., et al.
(författare)
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Measurement of the leptonic decay width of J/psi using initial state radiation
- 2016
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 761, s. 98-103
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Tidskriftsartikel (refereegranskat)abstract
- Using a data set of 2.93 fb(-1) taken at a center-of-mass energy of root s = 3.773 GeV with the BESIII detector at the BEPCII collider, we measure the process e(+) e(-) -> J/psi gamma -> mu(+)mu(-)gamma and determine the product of the branching fraction and the electronic width B-mu mu . Gamma(ee) = (333.4 +/- 2.5(stat) +/- 4.4(sys)) eV. Using the earlier-published BESIII result for B-mu mu = (5.973 +/- 0.007(stat) +/- 0.037(sys))%, we derive the J/psi electronic width Gamma(ee) = (5.58 +/- 0.05(stat) +/- 0.08(sys)) keV. (C) 2016 The Author(s). Published by Elsevier B.V.
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| 5. |
- Ablikim, M., et al.
(författare)
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Dark photon search in the mass range between 1.5 and 3.4 GeV/c
- 2017
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 774, s. 252-257
-
Tidskriftsartikel (refereegranskat)abstract
- Using a data set of 2.93 fb taken at a center-of-mass energy root s = 3.773 GeV with the BESIII detector at the BEPCII collider, we perform a search for an extra U(1) gauge boson, also denoted as a dark photon. We examine the initial state radiation reactions e(+)e(-) -> e(+)e(-) gamma(ISR) and e(+)e(-) -> mu(+)mu(-) gamma(ISR) for this search, where the dark photon would appear as an enhancement in the invariant mass distribution of the leptonic pairs. We observe no obvious enhancement in the mass range between 1.5 and 3.4 GeV/c(2) and set a 90% confidence level upper limit on the mixing strength of the dark photon and the Standard Model photon. We obtain a competitive limit in the tested mass range.
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| 6. |
- Ablikim, M., et al.
(författare)
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Measurement of the branching fractions of D-s(+) -> eta ' X and D-s(+) -> eta 'rho(+) in e(+)e(-) -> Ds+Ds-
- 2015
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 750, s. 466-474
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Tidskriftsartikel (refereegranskat)abstract
- We study D-s(+) decays to final states involving the eta' with a 482 pb(-1) data sample collected at root s = 4.009 GeV with the BESIII detector at the BEPCII collider. We measure the branching fractions B(D-s(+) -> eta'X) = (8.8 +/- 1.8 +/- 0.5)% and B(D-s(+) > eta'rho(+)) = (5.8 +/- 1.4 +/- 0.4)% where the first uncertainty is statistical and the second is systematic. In addition, we estimate an upper limit on the non-resonant branching ratio B(D-s(+) -> eta'pi(+)pi(0)) < 5.1% at the 90% confidence level. Our results are consistent with CLEO's recent measurements and help to resolve the disagreement between the theoretical prediction and CLEO's previous measurement of B(D-s(+) -> eta'rho(+)).
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| 7. |
- Ablikim, M., et al.
(författare)
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Measurement of the e(+)e(-) -> pi(+) pi(-) cross section between 600 and 900 MeV using initial state radiation
- 2016
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 753, s. 629-638
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Tidskriftsartikel (refereegranskat)abstract
- We extract the e(+) e(-) -> pi(+) pi(-) cross section in the energy range between 600 and 900 MeV, exploiting the method of initial state radiation. A data set with an integrated luminosity of 2.93 fb(-1) taken at a center-of-mass energy of 3.773 GeV with the BESIII detector at the BEPCII collider is used. The cross section is measured with a systematic uncertainty of 0.9%. We extract the pion form factor vertical bar F pi vertical bar(2) as well as the contribution of the measured cross section to the leading-order hadronic vacuum polarization contribution to (g - 2)(mu). We find this value to be a(mu)(pi pi,LO) (600-900 MeV) = (368.2 +/- 2.5(stat)+/- 3.3(sys)).10(-10), which is between the corresponding values using the BaBar or KLOE data.
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| 8. |
- Ablikim, M., et al.
(författare)
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Measurement of the matrix elements for the decays eta -> pi(+)pi(-)pi(0) and eta/eta ' -> pi(0)pi(0)pi(0)
- 2015
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 92:1
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Tidskriftsartikel (refereegranskat)abstract
- Based on a sample of 1.31 x 10(9) J/psi events collected with the BESIII detector at the BEPCII collider, Dalitz plot analyses of selected 79,625 eta -> pi(+)pi(-)pi(0) events, 33,908 eta -> pi(0)pi(0)pi(0) events, and 1,888 eta' -> pi(0)pi(0)pi(0) events are performed. The measured matrix elements of eta -> pi(+)pi(-)pi(0) are in reasonable agreement with previous measurements. The Dalitz plot slope parameters of eta -> pi(0)pi(0)pi(0) and eta' -> pi(0)pi(0)pi(0) are determined to be -0.055 +/- 0.014 +/- 0.004 and -0.640 +/- 0.046 +/- 0.047, respectively, where the first uncertainties are statistical and the second systematic. Both values are consistent with previous measurements, while the precision of the latter one is improved by a factor of 3. Final state interactions are found to have an important role in those decays.
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| 9. |
- Ablikim, M., et al.
(författare)
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Observation and Spin-Parity Determination of the X(1835) in J/psi -> gamma(KSKS0)-K-0 eta
- 2015
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:9
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Tidskriftsartikel (refereegranskat)abstract
- We report an observation of the process J/psi -> gamma X(1835) -> gamma(KSKS0)-K-0 eta at low (KSKS0)-K-0 mass with a statistical significance larger than 12.9s using a data sample of 1.31 x 109 J/psi events collected with the BESIII detector. In this region of phase space the (KSKS0)-K-0 system is dominantly produced through the f (0)(980). By performing a partial wave analysis, we determine the spin parity of the Xd1835_ to be J(PC) = 0(-+). The mass and width of the observed X(1835) are 1844 +/- 9(stat)(-25)(+16)(syst) MeV/c(2) and 192(-17)(+20)(sta)(-43)(+62)(syst) MeV, respectively, which are consistent with the results obtained by BESIII in the channel J/psi -> gamma pi(+)pi(-)eta'.
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| 10. |
- Ablikim, M., et al.
(författare)
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Observation of a Neutral Charmoniumlike State Z(c)(4025)(0) in e(+)e(-) -> (D*(D)over-bar*)(0)pi(0)
- 2015
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:18
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Tidskriftsartikel (refereegranskat)abstract
- We report a study of the process e(+)e(-) -> (D*(D) over bar*)(0)pi(0) using e(+)e(-) collision data samples with integrated luminosities of 1092 pb(-1) at root s = 4.23 GeV and 826 pb(-1) at root s = 4.26 GeV collected with the BESIII detector at the BEPCII storage ring. We observe a new neutral structure near the (D*(D) over bar*)(0) mass threshold in the pi(0) recoil mass spectrum, which we denote as Z(c)(4025)(0). Assuming a Breit-Wigner line shape, its pole mass and pole width are determined to be (4025.5(-4.7)(+2.0) +/- 3.1) MeV/c(2) and (23.0 +/- 6.0 +/- 1.0) MeV, respectively. The Born cross sections of e(+)e(-) -> Z(c)(4025)(0)pi(0) -> (D*(D) over bar*)(0)pi(0) are measured to be (61.6 +/- 8.2 +/- 9.0) pb at root s = 4.23 GeV and (43.4 +/- 8.0 +/- 5.4) pb at root s = 4.26 GeV. The first uncertainties are statistical and the second are systematic.
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| 11. |
- Ablikim, M., et al.
(författare)
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Observation of Z(c)(3900)(0) in e(+)e(-) -> pi(0)pi(0) J/Psi
- 2015
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:11
-
Tidskriftsartikel (refereegranskat)abstract
- Using a data sample collected with the BESIII detector operating at the BEPCII storage ring, we observe a new neutral state Z(c)(3900)(0) with a significance of 10.4 sigma. The mass and width are measured to be 3894.8 +/- 2.3 +/- 3.2 MeV/c(2) and 29.6 +/- 8.2 +/- 8.2 MeV, respectively, where the first error is statistical and the second systematic. The Born cross section for e(+)e(-) -> pi(0)pi(0) J/Psi and the fraction of it attributable to pi(0)Z(c)(3900)(0) -> pi(0)pi(0) J/Psi in the range E-c.m. = 4.19-4.42 GeV are also determined. We interpret this state as the neutral partner of the four-quark candidate Z(c)(3900)(+/-).
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| 12. |
- Ablikim, M., et al.
(författare)
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Search for Z(c)(3900)(+/-) -> omega pi(+/-)
- 2015
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 92:3
-
Tidskriftsartikel (refereegranskat)abstract
- The decay Z(c)(3900)(+/-) -> omega pi(+/-) is searched for using data samples collected with the BESIII detector operating at the BEPCII storage ring at center-of-mass energies root s = 4.23 and 4.26 GeV. No significant signal for the Z(c)(3900)(+/-) is found, and upper limits at the 90% confidence level on the Born cross section for the process e(+)e(-) -> Z(c)(3900)(+/-) pi(-/+) -> omega pi(+)pi(-) are determined to be 0.26 and 0.18 pb at root s = 4.23 and 4.26 GeV, respectively.
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| 13. |
- Ablikim, M., et al.
(författare)
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Measurement of azimuthal asymmetries in inclusive charged dipion production in $e^+e^-$ annihilations at $\sqrt{s}$ = 3.65 GeV
- 2016
-
Ingår i: PHYSICAL REVIEW LETTERS. - 0031-9007 .- 1079-7114. ; 116:4
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the azimuthal asymmetries of two charged pions in the inclusive process $e^+e^-\rightarrow \pi\pi X$ based on a data set of 62 $\rm{pb}^{-1}$ at the center-of-mass energy $\sqrt{s}=3.65$ GeV collected with the BESIII detector. These asymmetries can be attributed to the Collins fragmentation function. We observe a nonzero asymmetry, which increases with increasing pion momentum. As our energy scale is close to that of the existing semi-inclusive deep inelastic scattering experimental data, the measured asymmetries are important inputs for the global analysis of extracting the quark transversity distribution inside the nucleon and are valuable to explore the energy evolution of the spin-dependent fragmentation function.
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| 14. |
- Ablikim, M., et al.
(författare)
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Measurement of the branching fraction for psi(3770) -> gamma chi c0
- 2016
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 753, s. 103-109
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Tidskriftsartikel (refereegranskat)abstract
- By analyzing a data set of 2.92 fb(-1) of e(+) e(-) collision data taken at root s = 3.773 GeVand 106.41 x 10(6) psi(3686) decays taken at root s = 3.686 GeVwith the BESIII detector at the BEPCII collider, we measure the branching fraction and the partial decay width for psi(3770)->gamma chi c0 to be B(psi(3770)->gamma chi c0) = (6.88 +/- 0.28 +/- 0.67) x 10(-3) and Gamma[psi(3770)->gamma chi c0] = (187 +/- 8 +/- 19) keV, respectively. These are the most precise measurements to date.
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| 15. |
- Ablikim, M., et al.
(författare)
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Measurement of the form factors in the decay D+ → ωe+νe and search for the decay D+ → ϕe+νe
- 2015
-
Ingår i: Physical Review D. - : American Physical Society. - 1550-7998 .- 1550-2368. ; 92:7
-
Tidskriftsartikel (refereegranskat)abstract
- Using 2.92 fb−1 of electron-positron annihilation data collected at a center-of-mass energy of √s=3.773 GeV with the BESIII detector, we present an improved measurement of the branching fraction B(D+ → ωe+νe)=(1.63±0.11±0.08)×10−3. The parameters defining the corresponding hadronic form factor ratios at zero momentum transfer are determined for the first time; we measure them to be rV=1.24±0.09±0.06 and r2=1.06±0.15±0.05. The first and second uncertainties are statistical and systematic, respectively. We also search for the decay D+ → ϕe+νe. An improved upper limit B(D+ → ϕe+νe)<1.3×10−5 is set at 90% confidence level.
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| 16. |
- Ablikim, M., et al.
(författare)
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Measurements of Absolute Hadronic Branching Fractions of the Lambda(+)(c) Baryon
- 2016
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 116:5
-
Tidskriftsartikel (refereegranskat)abstract
- We report the first measurement of absolute hadronic branching fractions of Lambda(+)(c) baryon at the Lambda(+)(c)(Lambda) over bar (-)(c) production threshold, in the 30 years since the Lambda(+)(c) discovery. In total, 12 Cabibbo-favored Lambda(+)(c) hadronic decay modes are analyzed with a double-tag technique, based on a sample of 567 pb(-1) of e(+)e(-) collisions at root s = 4.599 GeV recorded with the BESIII detector. A global least-squares fitter is utilized to improve the measured precision. Among the measurements for twelve Lambda(+)(c) decay modes, the branching fraction for Lambda(+)(c) -> pK(-)pi(+) is determined to be (5.84 +/- 0.27 +/- 0.23)%, where the first uncertainty is statistical and the second is systematic. In addition, the measurements of the branching fractions of the other 11 Cabibbo-favored hadronic decay modes are significantly improved.
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| 17. |
- Ablikim, M., et al.
(författare)
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Observation of e(+)e(-) -> omega chi(c1,2) near root s=4.42 and 4.6 GeV
- 2016
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 93:1
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Tidskriftsartikel (refereegranskat)abstract
- Based on data samples collected with the BESIII detector operating at the BEPCII storage ring at center-of-mass energies root s > 4.4 GeV, the processes e(+)e(-) -> omega chi(c1,2) are observed for the first time. With an integrated luminosity of 1074 pb(-1) near root s = 4.42 GeV, a significant omega chi(c2) signal is found, and the cross section is measured to be (20.9 +/- 3.2 +/- 2.5) pb. With 567 pb(-1) near root s = 4.6 GeV, a clear omega chi(c2) signal is seen, and the cross section is measured to be (9.5 +/- 2.1 +/- 1.3) pb, while evidence is found for an omega chi(c2) signal. The first errors are statistical, and the second are systematic. Due to low luminosity or low cross section at other energies, no significant signals are observed. In the omega chi(c2) cross section, an enhancement is seen around root s = 4.42 GeV. Fitting the cross section with a coherent sum of the psi(4415) Breit-Wigner function and a phase-space term, the branching fraction B(psi(4415) -> omega chi(c2)) is obtained to be of the order of 10(-3).
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| 18. |
- Ablikim, M., et al.
(författare)
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Observation of eta ' -> omega e(+)e(-)
- 2015
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 92:5
-
Tidskriftsartikel (refereegranskat)abstract
- Based on a sample of eta' mesons produced in the radiative decay J/psi -> gamma eta' in 1.31 x 10(9) J/psi events collected with the BESIII detector, the decay eta' -> omega e(+)e(-) is observed for the first time, with a statistical significance of 8 sigma. The branching fraction is measured to be B(eta' -> omega e(+)e(-)) = (1.97 +/- 0.34(stat) +/- 0.17(syst)) x 10(-4), which is in agreement with theoretical predictions. The branching fraction of eta' -> omega gamma is also measured to be (2.55 +/- 0.03(stat) +/- 0.16(syst)) x 10(-2), which is the most precise measurement to date, and the relative branching fraction B(eta' -> omega e(+)e(-))/B(eta' -> omega gamma) is determined to be (7.71 +/- 1.34(stat) +/- 0.54(syst)) x 10(-3).
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| 19. |
- Ablikim, M., et al.
(författare)
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Study of dynamics of D-0 -> K(-)e(+)nu(e) and D-0 -> pi(-)e(+)nu(e) decays
- 2015
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 92:7
-
Tidskriftsartikel (refereegranskat)abstract
- In an analysis of a 2.92 fb(-1) data sample taken at 3.773 GeV with the BESIII detector operated at the BEPCII collider, we measure the absolute decay branching fractions B(D-0 -> K(-)e(+)nu(e)) = (3.505 +/- 0.014 +/- 0.033)% and B(D-0 -> pi(-)e(+)nu(e)) = (0.295 +/- 0.004 +/- 0.003)%. From a study of the differential decay rates we obtain the products of hadronic form factor and the magnitude of the Cabibbo-Kobayashi-Maskawa (CKM) matrix element f(+)(K)(0)vertical bar V-cs vertical bar = 0.7172 +/- 0.0025 +/- 0.0035 and f(+)(pi)(0)vertical bar V-cd vertical bar = 0.1435 +/- 0.0018 +/- 0.0009. Combining these products with the values of vertical bar V-cs(d)vertical bar from the SM constraint fit, we extract the hadronic form factors f(+)(K)(0) = 0.7368 +/- 0.0026 +/- 0.0036 and f(+)(pi)(0) = 0.6372 +/- 0.0080 +/- 0.0044, and their ratio f(+)(pi)(0)/f(+)(K)(0) = 0.8649 +/- 0.0112 +/- 0.0073. These form factors and their ratio are used to test unquenched lattice QCD calculations of the form factors and a light cone sum rule (LCSR) calculation of their ratio. The measured value of f(+)(K(pi))(0)vertical bar V-cs(d)vertical bar and the lattice QCD value for f(+)(K(pi))(0) are used to extract values of the CKM matrix elements of vertical bar V-cs vertical bar = 0.9601 +/- 0.0033 +/- 0.0047 +/- 0.0239 and vertical bar V-cd vertical bar = 0.2155 +/- 0.0027 +/- 0.0014 +/- 0.0094, where the third errors are due to the uncertainties in lattice QCD calculations of the form factors. Using the LCSR value for f(+)(pi)(0)/f(+)(K)(0), we determine the ratio vertical bar V-cd vertical bar/vertical bar V-cs vertical bar = 0.238 +/- 0.004 +/- 0.002 +/- 0.011, where the third error is from the uncertainty in the LCSR normalization. In addition, we measure form factor parameters for three different theoretical models that describe the weak hadronic charged currents for these two semileptonic decays. All of these measurements are the most precise to date.
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| 20. |
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| 21. |
- Edwards, Robert A., et al.
(författare)
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Global phylogeography and ancient evolution of the widespread human gut virus crAssphage
- 2019
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Ingår i: Nature Microbiology. - : Springer Science and Business Media LLC. - 2058-5276. ; 4:10, s. 1727-1736
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Tidskriftsartikel (refereegranskat)abstract
- Microbiomes are vast communities of microorganisms and viruses that populate all natural ecosystems. Viruses have been considered to be the most variable component of microbiomes, as supported by virome surveys and examples of high genomic mosaicism. However, recent evidence suggests that the human gut virome is remarkably stable compared with that of other environments. Here, we investigate the origin, evolution and epidemiology of crAssphage, a widespread human gut virus. Through a global collaboration, we obtained DNA sequences of crAssphage from more than one-third of the world's countries and showed that the phylogeography of crAssphage is locally clustered within countries, cities and individuals. We also found fully colinear crAssphage-like genomes in both Old-World and New-World primates, suggesting that the association of crAssphage with primates may be millions of years old. Finally, by exploiting a large cohort of more than 1,000 individuals, we tested whether crAssphage is associated with bacterial taxonomic groups of the gut microbiome, diverse human health parameters and a wide range of dietary factors. We identified strong correlations with different clades of bacteria that are related to Bacteroidetes and weak associations with several diet categories, but no significant association with health or disease. We conclude that crAssphage is a benign cosmopolitan virus that may have coevolved with the human lineage and is an integral part of the normal human gut virome.
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| 22. |
- Kruse, N., et al.
(författare)
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Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study
- 2015
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Ingår i: Neurobiology of Aging. - : Elsevier BV. - 0197-4580. ; 36:9, s. 2587-2596
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Tidskriftsartikel (refereegranskat)abstract
- Decreased levels of alpha-synuclein (aSyn) in cerebrospinal fluid (CSF) in Parkinson's disease and related synucleinopathies have been reported, however, not consistently in all cross-sectional studies. To test the performance of one recently released human-specific enzyme-linked immunosorbent assay (ELISA) for the quantification of aSyn in CSF, we carried out a round robin trial with 18 participating laboratories trained in CSF ELISA analyses within the BIOMARKAPD project in the EU Joint Program -Neurodegenerative Disease Research. CSF samples (homogeneous aliquots from pools) and ELISA kits (one lot) were provided centrally and data reported back to one laboratory for data analysis. Our study showed that although factors such as preanalytical sample handling and lot-to-lot variability were minimized by our study design, we identified high variation in absolute values of CSF aSyn even when the same samples and same lots of assays were applied. We further demonstrate that although absolute concentrations differ between laboratories the quantitative results are comparable. With further standardization this assay may become an attractive tool for comparing aSyn measurements in diverse settings. Recommendations for further validation experiments and improvement of the interlaboratory results obtained are given. (C) 2015 Elsevier Inc. All rights reserved.
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| 23. |
- van Doorn, Ljcv, et al.
(författare)
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Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes
- 2017
-
Ingår i: Journal of Alzheimers Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 56:2, s. 543-555
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Tidskriftsartikel (refereegranskat)abstract
- Cerebrospinal fluid (CSF) biomarkers may support the diagnosis of Alzheimer's disease (AD). We studied if the diagnostic power of AD CSF biomarker concentrations, i.e., A beta(42), total tau (t-tau), and phosphorylated tau (p-tau), is affected by differences in lateral ventricular volume (VV), using CSF biomarker data and magnetic resonance imaging (MRI) scans of 730 subjects, from 13 European Memory Clinics. We developed a Matlab-algorithm for standardized automated segmentation analysis of T1 weighted MRI scans in SPM8 for determining VV, and computed its ratio with total intracranial volume (TIV) as proxy for total CSF volume. The diagnostic power of CSF biomarkers (and their combination), either corrected for VV/TIV ratio or not, was determined by ROC analysis. CSF A beta(42) levels inversely correlated to VV/TIV in the whole study population (A beta(42): r = -0.28; p < 0.0001). For CSF t-tau and p-tau, this association only reached statistical significance in the combined MCI and AD group (t-tau: r = -0.15; p-tau: r = -0.13; both p < 0.01). Correction for differences in VV/TIV improved the differentiation of AD versus controls based on CSF A beta(42) alone (AUC: 0.75 versus 0.81) or in combination with t-tau (AUC: 0.81 versus 0.91). In conclusion, differences in VV may be an important confounder in interpreting CSF A beta(42) levels.
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| 24. |
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| 25. |
- Bowers, Robert M., et al.
(författare)
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Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea
- 2017
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Ingår i: Nature Biotechnology. - : NATURE PUBLISHING GROUP. - 1087-0156 .- 1546-1696. ; 35:8, s. 725-731
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Tidskriftsartikel (refereegranskat)abstract
- We present two standards developed by the Genomic Standards Consortium (GSC) for reporting bacterial and archaeal genome sequences. Both are extensions of the Minimum Information about Any (x) Sequence (MIxS). The standards are the Minimum Information about a Single Amplified Genome (MISAG) and the Minimum Information about a Metagenome-Assembled Genome (MIMAG), including, but not limited to, assembly quality, and estimates of genome completeness and contamination. These standards can be used in combination with other GSC checklists, including the Minimum Information about a Genome Sequence (MIGS), Minimum Information about a Metagenomic Sequence (MIMS), and Minimum Information about a Marker Gene Sequence (MIMARKS). Community-wide adoption of MISAG and MIMAG will facilitate more robust comparative genomic analyses of bacterial and archaeal diversity.
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