| 1. |
- Feroci, M., et al.
(author)
-
The large observatory for x-ray timing
- 2014
-
In: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 9780819496126
-
Conference paper (peer-reviewed)abstract
- The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final downselection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supranuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m2 effective area, 2-30 keV, 240 eV spectral resolution, 1° collimated field of view) and a Wide Field Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g. GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the status of the mission at the end of its Phase A study.
|
|
| 2. |
- Feroci, M., et al.
(author)
-
LOFT - The large observatory for x-ray timing
- 2012
-
In: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE - International Society for Optical Engineering. - 9780819491442 ; , s. 84432D-
-
Conference paper (peer-reviewed)abstract
- The LOFT mission concept is one of four candidates selected by ESA for the M3 launch opportunity as Medium Size missions of the Cosmic Vision programme. The launch window is currently planned for between 2022 and 2024. LOFT is designed to exploit the diagnostics of rapid X-ray flux and spectral variability that directly probe the motion of matter down to distances very close to black holes and neutron stars, as well as the physical state of ultradense matter. These primary science goals will be addressed by a payload composed of a Large Area Detector (LAD) and a Wide Field Monitor (WFM). The LAD is a collimated (<1 degree field of view) experiment operating in the energy range 2-50 keV, with a 10 m2 peak effective area and an energy resolution of 260 eV at 6 keV. The WFM will operate in the same energy range as the LAD, enabling simultaneous monitoring of a few-steradian wide field of view, with an angular resolution of <5 arcmin. The LAD and WFM experiments will allow us to investigate variability from submillisecond QPO's to yearlong transient outbursts. In this paper we report the current status of the project.
|
|
| 3. |
|
|
| 4. |
- Feroci, M., et al.
(author)
-
The Large Observatory for X-ray Timing (LOFT)
- 2012
-
In: Experimental Astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 34:2, s. 415-444
-
Journal article (peer-reviewed)abstract
- High-time-resolution X-ray observations of compact objects provide direct access to strong-field gravity, to the equation of state of ultradense matter and to black hole masses and spins. A 10 m(2)-class instrument in combination with good spectral resolution is required to exploit the relevant diagnostics and answer two of the fundamental questions of the European Space Agency (ESA) Cosmic Vision Theme "Matter under extreme conditions", namely: does matter orbiting close to the event horizon follow the predictions of general relativity? What is the equation of state of matter in neutron stars? The Large Observatory For X-ray Timing (LOFT), selected by ESA as one of the four Cosmic Vision M3 candidate missions to undergo an assessment phase, will revolutionise the study of collapsed objects in our galaxy and of the brightest supermassive black holes in active galactic nuclei. Thanks to an innovative design and the development of large-area monolithic silicon drift detectors, the Large Area Detector (LAD) on board LOFT will achieve an effective area of similar to 12 m(2) (more than an order of magnitude larger than any spaceborne predecessor) in the 2-30 keV range (up to 50 keV in expanded mode), yet still fits a conventional platform and small/medium-class launcher. With this large area and a spectral resolution of < 260 eV, LOFT will yield unprecedented information on strongly curved spacetimes and matter under extreme conditions of pressure and magnetic field strength.
|
|
| 5. |
- Gerotziafas, GT, et al.
(author)
-
Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine
- 2020
-
In: Thrombosis and haemostasis. - : Georg Thieme Verlag KG. - 2567-689X .- 0340-6245. ; 120:12, s. 1597-1628
-
Journal article (peer-reviewed)abstract
- COVID-19 is also manifested with hypercoagulability, pulmonary intravascular coagulation, microangiopathy, and venous thromboembolism (VTE) or arterial thrombosis. Predisposing risk factors to severe COVID-19 are male sex, underlying cardiovascular disease, or cardiovascular risk factors including noncontrolled diabetes mellitus or arterial hypertension, obesity, and advanced age. The VAS-European Independent Foundation in Angiology/Vascular Medicine draws attention to patients with vascular disease (VD) and presents an integral strategy for the management of patients with VD or cardiovascular risk factors (VD-CVR) and COVID-19. VAS recommends (1) a COVID-19-oriented primary health care network for patients with VD-CVR for identification of patients with VD-CVR in the community and patients' education for disease symptoms, use of eHealth technology, adherence to the antithrombotic and vascular regulating treatments, and (2) close medical follow-up for efficacious control of VD progression and prompt application of physical and social distancing measures in case of new epidemic waves. For patients with VD-CVR who receive home treatment for COVID-19, VAS recommends assessment for (1) disease worsening risk and prioritized hospitalization of those at high risk and (2) VTE risk assessment and thromboprophylaxis with rivaroxaban, betrixaban, or low-molecular-weight heparin (LMWH) for those at high risk. For hospitalized patients with VD-CVR and COVID-19, VAS recommends (1) routine thromboprophylaxis with weight-adjusted intermediate doses of LMWH (unless contraindication); (2) LMWH as the drug of choice over unfractionated heparin or direct oral anticoagulants for the treatment of VTE or hypercoagulability; (3) careful evaluation of the risk for disease worsening and prompt application of targeted antiviral or convalescence treatments; (4) monitoring of D-dimer for optimization of the antithrombotic treatment; and (5) evaluation of the risk of VTE before hospital discharge using the IMPROVE-D-dimer score and prolonged post-discharge thromboprophylaxis with rivaroxaban, betrixaban, or LMWH.
|
|
| 6. |
- Papitto, A., et al.
(author)
-
The INTEGRAL view of the pulsating hard X-ray sky : from accreting and transitional millisecond pulsars to rotation-powered pulsars and magnetars
- 2020
-
In: New astronomy reviews (Print). - : Elsevier BV. - 1387-6473 .- 1872-9630. ; 91
-
Journal article (peer-reviewed)abstract
- In the last 25 years a new generation of X-ray satellites imparted a significant leap forward in our knowledge of X-ray pulsars. The discovery of accreting and transitional millisecond pulsars proved that disk accretion can spin up a neutron star to a very high rotation speed. The detection of MeV-GeV pulsed emission from a few hundreds of rotation-powered pulsars probed particle acceleration in the outer magnetosphere, or even beyond. Also, a population of two dozens of magnetars has emerged. INTEGRAL played a central role to achieve these results by providing instruments with high temporal resolution up to the hard X-ray/soft, gamma-ray band and a large field of view imager with good angular resolution to spot hard X-ray transients. In this article we review the main contributions by INTEGRAL to our understanding of the pulsating hard X-ray sky, such as the discovery and characterization of several accreting and transitional millisecond pulsars, the generation of the first catalog of hard X-ray/soft gamma-ray rotation-powered pulsars, the detection of polarization in the hard X-ray emission from the Crab pulsar, and the discovery of persistent hard X-ray emission from several magnetars.
|
|
| 7. |
- Ambrozic, A, et al.
(author)
-
Corrigendum
- 2017
-
In: Journal of thrombosis and haemostasis : JTH. - : Elsevier BV. - 1538-7836. ; 15:6, s. 1236-1236
-
Journal article (peer-reviewed)
|
|
| 8. |
|
|
| 9. |
- Peterlongo, Paolo, et al.
(author)
-
FANCM c.5791C>T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factor.
- 2015
-
In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 24:18, s. 5345-5355
-
Journal article (peer-reviewed)abstract
- Numerous genetic factors that influence breast cancer risk are known. However, approximately two-thirds of the overall familial risk remain unexplained. To determine whether some of the missing heritability is due to rare variants conferring high to moderate risk, we tested for an association between the c.5791C>T nonsense mutation (p.Arg1931*; rs144567652) in exon 22 of FANCM gene and breast cancer. An analysis of genotyping data from 8635 familial breast cancer cases and 6625 controls from different countries yielded an association between the c.5791C>T mutation and breast cancer risk [odds ratio (OR) = 3.93 (95% confidence interval (CI) = 1.28-12.11; P = 0.017)]. Moreover, we performed two meta-analyses of studies from countries with carriers in both cases and controls and of all available data. These analyses showed breast cancer associations with OR = 3.67 (95% CI = 1.04-12.87; P = 0.043) and OR = 3.33 (95% CI = 1.09-13.62; P = 0.032), respectively. Based on information theory-based prediction, we established that the mutation caused an out-of-frame deletion of exon 22, due to the creation of a binding site for the pre-mRNA processing protein hnRNP A1. Furthermore, genetic complementation analyses showed that the mutation influenced the DNA repair activity of the FANCM protein. In summary, we provide evidence for the first time showing that the common p.Arg1931* loss-of-function variant in FANCM is a risk factor for familial breast cancer.
|
|
| 10. |
|
|
| 11. |
- Ageno, Walter, et al.
(author)
-
Managing reversal of direct oral anticoagulants in emergency situations Anticoagulation Education Task Force White Paper
- 2016
-
In: Thrombosis and Haemostasis. - : SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN. - 0340-6245 .- 2567-689X. ; 116:6, s. 1003-1010
-
Journal article (peer-reviewed)abstract
- Anticoagulation is the cornerstone of prevention and treatment of venous thromboembolism (VTE) and stroke prevention in patients with atrial fibrillation (AF). However, the mechanisms by which anticoagulants confer therapeutic benefit also increase the risk of bleeding. As such, reversal strategies are critical. Until recently, the direct oral anticoagulants (DOACs) dabigatran, rivaroxaban, apixaban, and edoxaban lacked a specific reversal agent. This report is based on findings from the Anticoagulation Education Task Force, which brought together patient groups and professionals representing different medical specialties with an interest in patient safety and expertise in AF, VTE, stroke, anticoagulation, and reversal agents, to discuss the current status of anticoagulation reversal and fundamental changes in management of bleeding associated with DOACs occasioned by the approval of idarucizumab, a specific reversal agent for dabigatran, as well as recent clinical data on specific reversal agents for factor Xa inhibitors. Recommendations are given for when there is a definite need for a reversal agent (e.g. in cases of life-threatening bleeding, bleeding into a closed space or organ, persistent bleeding despite local haemostatic measures, and need for urgent interventions and/or interventions that carry a high risk for bleeding), when reversal agents may be helpful, and when a reversal agent is generally not needed. Key stakeholders who require 24-7/around-the-clock access to these agents vary among hospitals; however, from a practical perspective the emergency department is recommended as an appropriate location for these agents. Clearly, the advent of new agents requires standardised protocols for treating bleeding on an institutional level.
|
|
| 12. |
- Kuiper, L., et al.
(author)
-
High-energy characteristics of the accretion-powered millisecond pulsar IGR J17591-2342 during its 2018 outburst : XMM-Newton, NICER, NuSTAR, and INTEGRAL view of the 0.3-300 keV X-ray band
- 2020
-
In: Astronomy and Astrophysics. - : EDP SCIENCES S A. - 0004-6361 .- 1432-0746. ; 641
-
Journal article (peer-reviewed)abstract
- IGR J17591-2342 is an accreting millisecond X-ray pulsar, discovered with INTEGRAL, which went into outburst around July 21, 2018. To better understand the physics acting in these systems during the outburst episode, we performed detailed temporal-, timing-, and spectral analyses across the 0.3-300 keV band using data from NICER, XMM-Newton, NuSTAR, and INTEGRAL. The hard X-ray 20-60 keV outburst profile covering similar to 85 days is composed of four flares. Over the course of the maximum of the last flare, we discovered a type-I thermonuclear burst in INTEGRAL JEM-X data, posing constraints on the source distance. We derived a distance of 7.6 +/- 0.7 kpc, adopting Eddington-limited photospheric radius expansion and assuming anisotropic emission. In the timing analysis, using all NICER 1-10 keV monitoring data, we observed a rather complex set of behaviours starting with a spin-up period (MJD 58345-58364), followed by a frequency drop (MJD 58364-58370), an episode of constant frequency (MJD 58370-58383), concluded by irregular behaviour till the end of the outburst. The 1-50 keV phase distributions of the pulsed emission, detected up to similar to 120 keV using INTEGRAL ISGRI data, was decomposed in three Fourier harmonics showing that the pulsed fraction of the fundamental increases from similar to 10% to similar to 17% going from similar to 1.5 to similar to 4 keV, while the harder photons arrive earlier than the soft photons for energies less than or similar to 10 keV. The total emission spectrum of IGR J17591-2342 across the 0.3-150 keV band could adequately be fitted in terms of an absorbed COMPPS model yielding as best fit parameters a column density of N-H=(2.09 +/- 0.05) x 10(22) cm(-2), a blackbody seed photon temperature kT(bb, seed) of 0.64 +/- 0.02 keV, electron temperature kT(e)=38.8 +/- 1.2 keV and Thomson optical depth tau (T)=1.59 +/- 0.04. The fit normalisation results in an emission area radius of 11.3 +/- 0.5 km adopting a distance of 7.6 kpc. Finally, the results are discussed within the framework of accretion physics- and X-ray thermonuclear burst theory.
|
|
| 13. |
- Lammer, H., et al.
(author)
-
The Science of Exoplanets and Their Systems
- 2013
-
In: Astrobiology. - : Mary Ann Liebert Inc. - 1531-1074 .- 1557-8070. ; 13:9, s. 793-813
-
Journal article (peer-reviewed)abstract
- A scientific forum on The Future Science of Exoplanets and Their Systems, sponsored by Europlanet(*) and the International Space Science Institute (ISSI)(dagger) and co-organized by the Center for Space and Habitability (CSH)(double dagger) of the University of Bern, was held during December 5 and 6, 2012, in Bern, Switzerland. It gathered 24 well-known specialists in exoplanetary, Solar System, and stellar science to discuss the future of the fast-expanding field of exoplanetary research, which now has nearly 1000 objects to analyze and compare and will develop even more quickly over the coming years. The forum discussions included a review of current observational knowledge, efforts for exoplanetary atmosphere characterization and their formation, water formation, atmospheric evolution, habitability aspects, and our understanding of how exoplanets interact with their stellar and galactic environment throughout their history. Several important and timely research areas of focus for further research efforts in the field were identified by the forum participants. These scientific topics are related to the origin and formation of water and its delivery to planetary bodies and the role of the disk in relation to planet formation, including constraints from observations as well as star-planet interaction processes and their consequences for atmosphere-magnetosphere environments, evolution, and habitability. The relevance of these research areas is outlined in this report, and possible themes for future ISSI workshops are identified that may be proposed by the international research community over the coming 2-3 years.
|
|
| 14. |
- Li, Z., et al.
(author)
-
Mixed H/He bursts in SAX J1748.9-2021 during the spectral change of its 2015 outburst
- 2018
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 620
-
Journal article (peer-reviewed)abstract
- SAX J1748.9-2021 is a transiently accreting X-ray millisecond pulsar. It is also known as an X-ray burster source discovered by Beppo-SAX. We analyzed the persistent emission and type-I X-ray burst properties during its 2015 outburst. The source changed from hard to soft state within half day. We modeled the broadband spectra of the persistent emission in the (1-250) keV energy band for both spectral states using the quasi-simultaneous INTEGRAL and Swift data. The broadband spectra are well fitted by an absorbed thermal Componization model, COMPPS, in a slab geometry. The best-fits for the two states indicate significantly different plasma temperature of 18 and 5 keV and the Thomson optical depths of three and four, respectively. In total, 56 type-I X-ray bursts were observed during the 2015 outburst, of which 26 detected by INTEGRAL in the hard state, 25 by XMM-Newton in the soft state, and five by Swift in both states. As the object transited from the hard to the soft state, the recurrence time for X-ray bursts decreased from approximate to 2 to approximate to 1 h. The relation between the recurrence time, Delta t(rec )and the local mass accretion rate per unit area onto the compact object, in, is fitted by a power-law model, and yielded as best fit at Delta t(rec )similar to <(m) over dot >(-1)(.0)(2 +/-)(0.)(03) using all X-ray bursts. In both cases, the observed recurrence times are consistent with the mixed hydrogen and helium bursts. We also discuss the effects of type-I X-ray bursts prior to the hard to soft transition.
|
|
