| 1. |
- De Stefano, V., et al.
(författare)
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High rate of recurrent venous thromboembolism in patients with myeloproliferative neoplasms and effect of prophylaxis with Vitamin K antagonists
- 2016
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Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 30:10, s. 2032-2038
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Tidskriftsartikel (refereegranskat)abstract
- The optimal duration of treatment with vitamin K antagonists (VKA) after venous thromboembolism (VTE) in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) is uncertain. To tackle this issue, we retrospectively studied 206 patients with MPN-related VTE (deep venous thrombosis of the legs and/or pulmonary embolism). After this index event, we recorded over 695 pt-years 45 recurrences, venous in 36 cases, with an incidence rate (IR) of 6.5 per 100 pt-years (95% confidence interval (CI): 4.9-8.6). One hundred fifty-five patients received VKA; the IR of recurrent thrombosis per 100 pt-years was 4.7 (95% CI: 2.8-7.3) on VKA and 8.9 (95% CI: 5.7-13.2) off VKA (P=0.03). In patients receiving VKA, the IR of recurrent thrombosis per 100 pt-years was 5.3 (95% CI: 3.2-8.4) among 108 patients on long-term VKA and 12.8 (95% CI: 7.3-20.7) after discontinuation among the 47 who ceased treatment (P=0.008), with a doubled risk of recurrence after stopping VKA (hazard ratio: 2.21, 95% CI: 1.19-5.30). The IR of major bleeding per 100 pt-years was 2.4 (95%: CI: 1.1-4.5) on VKA and 0.7 (95% CI: 0.08-2.5) off VKA (P=0.08). In conclusion, in MPN patients with VTE recurrent thrombosis is significantly reduced by VKA and caution should be adopted in discontinuation; however, the incidence of recurrence on treatment remains high, calling for clinical trials aimed to improve prophylaxis in this setting.
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| 2. |
- De Stefano, V., et al.
(författare)
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Splanchnic vein thrombosis in myeloproliferative neoplasms : Risk factors for recurrences in a cohort of 181 patients
- 2016
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Ingår i: Blood Cancer Journal. - : Springer Science and Business Media LLC. - 2044-5385. ; 6:11
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Tidskriftsartikel (refereegranskat)abstract
- We retrospectively studied 181 patients with polycythaemia vera (n=67), essential thrombocythaemia (n=67) or primary myelofibrosis (n=47), who presented a first episode of splanchnic vein thrombosis (SVT). Budd-Chiari syndrome (BCS) and portal vein thrombosis were diagnosed in 31 (17.1%) and 109 (60.3%) patients, respectively; isolated thrombosis of the mesenteric or splenic veins was detected in 18 and 23 cases, respectively. After this index event, the patients were followed for 735 patient years (pt-years) and experienced 31 recurrences corresponding to an incidence rate of 4.2 per 100 pt-years. Factors associated with a significantly higher risk of recurrence were BCS (hazard ratio (HR): 3.03), history of previous thrombosis (HR: 3.62), splenomegaly (HR: 2.66) and leukocytosis (HR: 2.8). Vitamin K-antagonists (VKA) were prescribed in 85% of patients and the recurrence rate was 3.9 per 100 pt-years, whereas in the small fraction (15%) not receiving VKA more recurrences (7.2 per 100 pt-years) were reported. Intracranial and extracranial major bleeding was recorded mainly in patients on VKA and the corresponding rate was 2.0 per 100 pt-years. In conclusion, despite anticoagulation treatment, the recurrence rate after SVT in myeloproliferative neoplasms is high and suggests the exploration of new avenues of secondary prophylaxis with new antithrombotic drugs and JAK-2 inhibitors.
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| 3. |
- Razaq, A., et al.
(författare)
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Phylogeography and diversification of Oriental weaverbirds (Ploceus spp.): A gradual increase of eurytopy
- 2023
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Ingår i: Avian Research. - 2053-7166. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- Weaverbirds are a speciose group of colorful passerines inhabiting the Old World Tropics. Nevertheless, the Oriental weaverbirds (Ploceus spp.), widespread across southern Asia, are much less diverse and restricted to a few ecological niches compared to their African counterpart. To investigate their phylogeography, we retrieved 101 samples of Baya Weaver (P. philippinus), Streaked Weaver (P. manyar), Black-Throated Weaver (P. benghalensis) and Asian Golden Weaver (P. hypoxanthus) along with GenBank sequences of Finn's Weaver (P. megarhynchus). We reconstructed the first molecular phylogeny based on a dataset consisting of both mitochondrial and nuclear genes, dating the most recent common ancestor of Oriental Ploceus to similar to 11 mya. Subsequent speciation appears to have been a combination of divergence within the Indian subcontinent and dispersal across a barrier situated between the Indian subcontinent and the Indochinese region, which provided habitats with a varying degree of isolations and ultimately promoted divergences in allopatry. Two descendants of the earliest nodes, P. megarhynchus and P. hypoxanthus, are both rare and local, often found near large river systems, which perhaps reflects niche conservatism and a lack of adaptive potential. The three smaller species are all widespread, common and less habitat specific. The most recent divergence, between western and eastern P. philippinus populations, is supported by both phylogenetic and morphological evidence, pointing toward limited gene flow between them. However, a zone of intergradation may exist in Myanmar and Brahmaputra flood plains, thus preventing a recommendation for species level recognition without further study.
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| 4. |
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| 5. |
- Castagnari, C., et al.
(författare)
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Lightweight preprocessing for agent-based simulation of smart mobility initiatives
- 2018
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Ingår i: Lect. Notes Comput. Sci.. - Cham : Springer Verlag. - 9783319747804 ; , s. 541-557
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Konferensbidrag (refereegranskat)abstract
- Understanding the impacts of a mobility initiative prior to deployment is a complex task for both urban planners and transport companies. To support this task, Tangramob offers an agent-based simulation framework for assessing the evolution of urban traffic after the introduction of new mobility services. However, Tangramob simulations are computationally expensive due to their iterative nature. Thus, we simplified the Tangramob model into a Timed Rebeca (TRebeca) model and we designed a tool-chain that generates instances of this model starting from the same Tangramob’s inputs. Running TRebeca models allows users to get an idea of how mobility initiatives affect the system performance, in a short time, without resorting to the simulator. To validate this approach, we compared the output of both the simulator and the TRebeca model on a collection of mobility initiatives. Results show a correlation between them, thus demonstrating the usefulness of using TRebeca models for unconventional contexts of application.
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| 6. |
- de Berardinis, J., et al.
(författare)
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Actor-based macroscopic modeling and simulation for smart urban planning
- 2018
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Ingår i: Science of Computer Programming. - : Elsevier B.V.. - 0167-6423 .- 1872-7964. ; 168, s. 142-164
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Tidskriftsartikel (refereegranskat)abstract
- Assessing the impacts of a mobility initiative prior to deployment is a complex task for both urban planners and transport companies. Computational models like Tangramob offer an agent-based framework for simulating the evolution of urban traffic after the introduction of new mobility services. However, simulations can be computationally expensive to perform due to their iterative nature and the microscopic representation of traffic. To address this issue, we designed a simplified model architecture of Tangramob in Timed Rebeca (TRebeca) and we developed a tool-chain for the generation runnable instances of this model starting from the same input files of Tangramob. Running TRebeca models allows users to get an idea of how the mobility initiatives under study affect the traveling experience of commuters, in a short time and without the need to use the simulator during this first experimental step. Then, once a subset of these initiatives is identified according to user's criteria, it is reasonable to simulate them with Tangramob in order to get more detailed results. To validate this approach, we compared the output of both the simulator and the TRebeca model on a collection of mobility initiatives. The correlation between the results demonstrates the usefulness of using TRebeca models for unconventional contexts of application.
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| 7. |
- Forcina, Giorgio, et al.
(författare)
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Safe design of flow management systems using rebeca
- 2020
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Ingår i: Journal of Information Processing. - : Information Processing Society of Japan. - 0387-5806 .- 1882-6652. ; 28, s. 588-598
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Tidskriftsartikel (refereegranskat)abstract
- Track-based flow management systems like transportation systems and traffic control systems play a crucial role in our daily life. Safety and performance are among the most important quality requirements for these systems. This paper presents AdaptiveFlow as a framework for modeling, safety checking and performance analysis of track-based flow management systems. AdaptiveFlow is based on the Hewitt actors computation model. In particular, tracks are modeled as actors and moving objects as messages. Timed Rebeca is used for modeling, and the model checking tool Afra is used for safety verification and performance evaluation in AdaptiveFlow. To react to dynamic changes in the environment, AdaptiveFlow provides support for three adaptive policies, which can be examined and compared in different scenarios. To demonstrate the applicability of AdaptiveFlow, we consider the Electric Site Research Project of Volvo Construction Equipment as a case study. In this project, a fleet of autonomous haulers is utilized to transport materials in a quarry site. Furthermore, to show the reusability of the framework for other flow management scenarios, an experiment on an urban garbage collection system is presented. © 2020 Information Processing Society of Japan.
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