| 1. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 2. |
- Fallerini, Chiara, et al.
(författare)
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Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
- 2022
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Ingår i: Human Genetics. - : Springer Nature. - 0340-6717 .- 1432-1203. ; 141:1, s. 147-173
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Tidskriftsartikel (refereegranskat)abstract
- The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management.
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| 3. |
- Barbieri, Maurizio, et al.
(författare)
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Changes in groundwater trace element concentrations before seismic and volcanic activities in Iceland during 2010-2018
- 2021
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 793
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Tidskriftsartikel (refereegranskat)abstract
- We analysed temporal variations of trace element concentrations in groundwater from a 101 m-deep borehole (HA01) in northern Iceland during 2010–2018 and compared them with seismic and volcanic events that occurred in the same period to identify potential hydrogeochemical precursors. An increase of B, Al, V, Li and Mo concentrations started from eight months to one month before the 2014 Bárðarbunga eruption (~115 km from HA01), a major rifting event in central Iceland, while Ga and V concentrations began to increase one day and one month after the onset of the event, respectively. We also found that concentrations of some trace elements (Li, B, Ga, Mo, Sr, Rb and Fe) significantly increased before an Mw 5.0 earthquake that occurred ~80 km from the borehole in 2018. However, other notable hydrogeochemical changes were detected during the monitoring period without apparent correlation with the seismic and volcanic events in the region. This study shows that the systematic long-term hydrogeochemical monitoring in seismic and volcanic areas is critical to advance the science of seismic and eruptive precursors. Furthermore, the use of statistical tools, such as Principal Component Analysis (PCA) and Change Point (CP) detection can help identify the most useful chemical elements and validate the trend variability of those elements in the time series, reducing arbitrary choices of pre-seismic and pre-volcanic hydrogeochemical anomalies as potential precursors.
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| 4. |
- Di Saverio, Salomone, et al.
(författare)
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Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines
- 2020
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Ingår i: World Journal of Emergency Surgery. - : BMC. - 1749-7922. ; 15:1
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Forskningsöversikt (refereegranskat)abstract
- Background and aims Acute appendicitis (AA) is among the most common causes of acute abdominal pain. Diagnosis of AA is still challenging and some controversies on its management are still present among different settings and practice patterns worldwide. In July 2015, the World Society of Emergency Surgery (WSES) organized in Jerusalem the first consensus conference on the diagnosis and treatment of AA in adult patients with the intention of producing evidence-based guidelines. An updated consensus conference took place in Nijemegen in June 2019 and the guidelines have now been updated in order to provide evidence-based statements and recommendations in keeping with varying clinical practice: use of clinical scores and imaging in diagnosing AA, indications and timing for surgery, use of non-operative management and antibiotics, laparoscopy and surgical techniques, intra-operative scoring, and peri-operative antibiotic therapy. Methods This executive manuscript summarizes the WSES guidelines for the diagnosis and treatment of AA. Literature search has been updated up to 2019 and statements and recommendations have been developed according to the GRADE methodology. The statements were voted, eventually modified, and finally approved by the participants to the consensus conference and by the board of co-authors, using a Delphi methodology for voting whenever there was controversy on a statement or a recommendation. Several tables highlighting the research topics and questions, search syntaxes, and the statements and the WSES evidence-based recommendations are provided. Finally, two different practical clinical algorithms are provided in the form of a flow chart for both adults and pediatric (< 16 years old) patients. Conclusions The 2020 WSES guidelines on AA aim to provide updated evidence-based statements and recommendations on each of the following topics: (1) diagnosis, (2) non-operative management for uncomplicated AA, (3) timing of appendectomy and in-hospital delay, (4) surgical treatment, (5) intra-operative grading of AA, (6) ,management of perforated AA with phlegmon or abscess, and (7) peri-operative antibiotic therapy.
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| 5. |
- Goudzovski, Evgueni, et al.
(författare)
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New physics searches at kaon and hyperon factories
- 2023
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Ingår i: Reports on progress in physics (Print). - : Institute of Physics (IOP). - 0034-4885 .- 1361-6633. ; 86:1
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Forskningsöversikt (refereegranskat)abstract
- Rare meson decays are among the most sensitive probes of both heavy and light new physics. Among them, new physics searches using kaons benefit from their small total decay widths and the availability of very large datasets. On the other hand, useful complementary information is provided by hyperon decay measurements. We summarize the relevant phenomenological models and the status of the searches in a comprehensive list of kaon and hyperon decay channels. We identify new search strategies for under-explored signatures, and demonstrate that the improved sensitivities from current and next-generation experiments could lead to a qualitative leap in the exploration of light dark sectors.
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| 6. |
- Viola, N., et al.
(författare)
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H2020 STRATOFLY PROJECT : FROM EUROPE TO AUSTRALIA IN LESS THAN 3 HOURS
- 2021
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Ingår i: 32nd Congress of the International Council of the Aeronautical Sciences, ICAS 2021. - 9783932182914
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Konferensbidrag (refereegranskat)abstract
- As eluded in previous studies, with special reference to those carried out in the European framework, some innovative high-speed aircraft configurations have now the potential to assure an economically viable high-speed aircraft fleet. They make use of unexploited flight routes in the stratosphere, offering a solution to the presently congested flight paths while ensuring a minimum environmental impact in terms of emitted noise and green-house gases, particularly during stratospheric cruise. However, only a dedicated multi-disciplinary integrated design approach could realize this, by considering airframe architectures embedding the propulsion systems as well as meticulously integrating crucial subsystems. In this context, starting from an in-depth investigation of the current status of the activities, the STRATOFLY project has been funded by the European Commission, under the framework of Horizon 2020 plan, with the aim of assessing the potential of this type of high-speed transport vehicle to reach Technology Readiness Level (TRL) 6 by 2035, with respect to key technological, societal and economical aspects. This paper aims at summarizing the main results achieved so far to solve the main issues related to thermal and structural integrity, low-emissions combined propulsion cycles, subsystems design and integration, including smart energy management, environmental aspects impacting climate change, noise emissions and social acceptance, and economic viability accounting for safety and human factors.
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| 7. |
- Viola, Nicole, et al.
(författare)
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Stratofly mr3 – how to reduce the environmental impact of high-speed transportation
- 2021
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Ingår i: AIAA Scitech 2021 Forum. - 9781624106095 ; , s. 1-21
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Konferensbidrag (refereegranskat)abstract
- This paper addresses the main progresses and achievements of the H2020 STRATOFLY Project, funded by the European Commission, under the Horizon 2020 framework, specifically looking at the latest results in terms of environmental sustainability. In particular, starting from reporting the main environmental challenges posed by high-speed civil transportation, at local, regional and global levels, this paper describes the way in which the STRATOFLY MR3 vehicle, a Mach 8 waverider fueled with liquid hydrogen, promises to limit the overall environmental impact. In details, firstly, the paper describes some of the main technological improvements adopted to reduce the aircraft emission and then it reports about the status of the numerical and experimental test campaigns on the high-speed engine, showing the results achieved so far. This preliminary emission inventory allows for the evaluation of emission indexes throughout the mission profile, the verification of the compliance with the ICAO prescriptions, the estimation of the impact on air quality and climate and eventually, when necessary, the paper proposes adequate mitigation actions.
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