| 1. |
|
|
| 2. |
- Borggren, Marie, et al.
(författare)
-
Evolution of DC-SIGN use revealed by fitness studies of R5 HIV-I variants emerging during AIDS progression
- 2008
-
Ingår i: Retrovirology. - : Springer Science and Business Media LLC. - 1742-4690. ; 5:28
-
Tidskriftsartikel (refereegranskat)abstract
- Background: At early stages of infection CCR5 is the predominant HIV-1 coreceptor, but in approximately 50% of those infected CXCR4-using viruses emerge with disease progression. This coreceptor switch is correlated with an accelerated progression. However, those that maintain virus exclusively restricted to CCR5 (R5) also develop AIDS. We have previously reported that R5 variants in these "non-switch virus" patients evolve during disease progression towards a more replicative phenotype exhibiting altered CCR5 coreceptor interactions. DC-SIGN is a C-type lectin expressed by dendritic cells that HIV-1 may bind and utilize for enhanced infection of T cells in trans. To further explore the evolution of the R5 phenotype we analyzed sequential R5 isolates obtained before and after AIDS onset, i.e. at the chronic stage and during end-stage disease, with regard to efficiency of DC-SIGN use in trans-infections. Results: Results from binding and trans-infection assays showed that R5 viruses emerging during end-stage AIDS disease displayed reduced ability to use DC-SIGN. To better understand viral determinants underlying altered DC-SIGN usage by R5 viruses, we cloned and sequenced the HIV-1 env gene. We found that end-stage R5 viruses lacked potential N-linked glycosylation sites (PNGS) in the gp120 V2 and V4 regions, which were present in the majority of the chronic stage R5 variants. One of these sites, amino acid position 160 (aa160) in the V2 region, also correlated with efficient use of DC-SIGN for binding and trans-infections. In fitness assays, where head-to-head competitions between chronic stage and AIDS R5 viruses were setup in parallel direct and DCSIGN-mediated infections, results were further supported. Competitions revealed that R5 viruses obtained before AIDS onset, containing the V2 PNGS at aa160, were selected for in the transinfection. Whereas, in agreement with our previous studies, the opposite was seen in direct target cell infections where end-stage viruses out-competed the chronic stage viruses. Conclusion: Results of our study suggest R5 virus variants with diverse fitness for direct and DCSIGN-mediated trans-infections evolve within infected individuals at end-stage disease. In addition, our results point to the importance of a glycosylation site within the gp120 V2 region for efficient DC-SIGN use of HIV-1 R5 viruses.
|
|
| 3. |
- Finizia, Caterina, 1961, et al.
(författare)
-
Advanced laryngeal cancer T3-T4 in Sweden: a retrospective study 1986-1990. Survival and locoregional control related to treatment.
- 1996
-
Ingår i: Acta oto-laryngologica. - : Informa UK Limited. - 0001-6489 .- 1651-2251. ; 116:6, s. 906-12
-
Tidskriftsartikel (refereegranskat)abstract
- Different treatment modalities for advanced laryngeal cancer are much discussed in the literature. One-hundred-and-sixty patients with T3-4, N0-3, M0-1 laryngeal cancer diagnosed in Sweden between 1986 and 1990 were retrospectively analysed. One hundred (65 T3: 35 T4) received radical radiotherapy with salvage surgery (RRSS) in case of residual or recurrent disease. Thirty-eight (11T3: 27 T4) patients received surgery with or without radiotherapy (S +/- RT). Twenty-two patients received no treatment. After a median follow up of 4.4 years, the estimated 5-year actuarial corrected survival and 3-year locoregional control were 59% and 44% for T3 RRSS and 47% and 54% for T3 S +/- RT. No significant difference between the different treatment modalities was found. The 5-year corrected survival rate and the locoregional control at 3 years between T4-RRSS (32%; 26%) and T4-S + RT (58%; 68%) groups were significantly different (p < 0.05 and p < 0.01). This might suggest that surgery with or without radiotherapy still has its place as a treatment modality for patients with advanced T4 laryngeal carcinoma.
|
|
| 4. |
|
|
| 5. |
- Dasandi, N., et al.
(författare)
-
The inclusion of health in major global reports on climate change and biodiversity
- 2022
-
Ingår i: Bmj Global Health. - : BMJ. - 2059-7908. ; 7:6
-
Tidskriftsartikel (refereegranskat)abstract
- This article argues that human health has become a key consideration in recent global reports on climate change and biodiversity produced by various international organisations; however, greater attention must be given to the unequal health impacts of climate change and biodiversity loss around the world and the different health adaptation measures that are urgently required.
|
|
| 6. |
- Eriksson, M. G., et al.
(författare)
-
Cross-sectoral Approaches Help Build Water Resilience – Reflections
- 2014
-
Ingår i: Aquatic Procedia. - : Elsevier BV. - 2214-241X. ; 2, s. 42-47
-
Tidskriftsartikel (refereegranskat)abstract
- Future challenges for the planet includes e.g. population growth, climate change and urbanisation. The combined pressure from these and other processes on water, energy and ecosystem services call for cross-sectoral approaches to increase the resilience of society, with particular aim to reduce hydro-climatic hazards and secure water availability of sufficient quantity and quality. In the global strife to achieve this water resilience, we pinpoint four strategies of pivotal importance. These are: 1) to ensure sustainable utilisation of ecosystems and their services; 2) to ensure that interventions for increased resilience are tailor-made to local conditions; 3) to broaden livelihood opportunities in order to make income-generating activities less dependent on only one sector or resource; and 4) to facilitate interactions between rural and urban areas and processes. Although the challenges mentioned are largely human induced, the power to address these are also within human reach. It is only if we properly facilitate work building on the linkages between humans and the environment that we can enhance water resilience.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
|
|
| 17. |
- Kuylenstierna, D., et al.
(författare)
-
VALIDATION, ACCURACY AND PRACTICAL USE OF A POWER MEASUREMENT SYSTEM FOR CROSS-COUNTRY SKIING ANALYSIS – A PILOT STUDY
- 2020
-
Ingår i: Karczewska-Lindinger, M., Hakkarainen, A., Linnamo, V., Lindinger, S. (2020) (Eds), Science and Skiing VIII, University of Jyväskylä. - Jyväskylä, Finland : University of Jyväskylä. - 9789513980771 ; , s. 154-161
-
Bokkapitel (refereegranskat)
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
- Mattsson, Tobias, 1990-, et al.
(författare)
-
Quantifying the crystal cargo of the Cerro Bayo cryptodome, Argentina; A window into pre-emplacement magma processes and storage conditions
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Shallow plumbing systems with intermediate to evolved volcanic systems can show complex magma recycling and recharge systematics. Such evidence is often stored in the information looked within the crystal cargo found in shallow systems. The Cerro Bayo cryptodome provides a classic example of such processes and was emplaced in the upper kilometre of the Miocene, back-arc Chachahuén volcano. Cerro Bayo formed during an extensive dome-building (and collapse) stage of the Chachahuén volcano, and is composed of a porphyritic trachyandesite which contains numerous mafic enclaves. This contribution investigates the deeper magma plumbing system and magmatic processes preceding the emplacement of Cerro Bayo with petrography, mineral chemistry, crystal size distributions and thermobarometry. The main crystals found in Cerro Bayo are plagioclase and amphiboles, found as mixed phenocryst/antecryst and glomerocryts, constituting about 30 vol. % of the rock. Minor mineral phases include pyroxene, apatite and magnetite. Several crystal populations are identified within the Cerro Bayo, which indicate differences within the growth histories of the populations. Some plagioclase crystal display resorbed textures and show zones with sharp increases in An mol% (up to 25 %), indicative of recharge events with hot (more mafic) magma. Whereas other crystals record only small temperature shifts, likely induced by latent heat of crystallisation. Amphibole and clinopyroxene barometers yield average crystallisation pressure estimates that range from 740 to 1036 MPa, however, they overlap within error of the barometers, revealing a storage region prior to shallow emplacement at about 30 to 40 km depth in the lower crust. The voluminous crystal cargo, diverse zoning patterns, sieve-textured plagioclase and the abundant enclaves in Cerro Bayo suggest that the magma was derived from a crystal mush storage region that was mobilised and partly mixed by the recharge of mafic melt.
|
|
| 22. |
|
|
| 23. |
|
|
| 24. |
|
|
| 25. |
- Thorstensson, H, et al.
(författare)
-
Medical status and complications in relation to periodontal disease experience in insulin-dependent diabetics.
- 1996
-
Ingår i: Journal of Clinical Periodontology. - 0303-6979 .- 1600-051X. ; 23:3 Pt 1, s. 194-202
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to define a population of diabetics exhibiting an increased risk of developing severe periodontitis by comparing the medical status of 2 groups of diabetics, 1 with no/minor periodontal disease and 1 with severe periodontal disease. The case-control study consisted of 2 parts, a baseline study and a follow-up study. 39 case-control pairs were selected. They were adult, long-duration, insulin-dependent diabetics matched according to sex, age and diabetes duration. One individual in each pair (the CASE) exhibited severe periodontal disease while the other (the CONTROL) exhibited gingivitis or only minor alveolar bone loss. The median age of the cases was 58 years (range 36 to 70 years) and of the controls 59 years (range 37 to 69 years). The median disease duration in cases and controls was 24 years and 25 years, respectively. The median follow-up time was 6 years. The medical variables analysed were weight, insulin dose, systolic and diastolic blood pressure, vibratory threshold, triglycerides, total-cholesterol, HDL-cholesterol, creatinine, HbA1, proteinuria, ECG, retinopathy, stroke, transient ischemic attacks (TIA), angina, myocardial infarct, heart failure, hypertension, intermittent claudication, foot ulcer, death, cause of death, and smoking habit. Biochemical analyses and clinical variables used as a routine in the monitoring of diabetics failed to differentiate between diabetics with severe and minor periodontal disease. In the follow-up study, significantly higher prevalences of proteinuria and cardiovascular complications such as stroke, TIA, angina, myocardial infarct and intermittent claudication were found in the case group. An association between renal disease, cardiovascular complications and severe periodontitis seems to exist. This indicates that a closer cooperation between the diabetologist and the dentist is necessary in monitoring the diabetic patient.
|
|
