| 1. |
- Hu, Wenping, et al.
(författare)
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Advancing conjugated polymers into nanometer-scale devices
- 2006
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Ingår i: Pure and Applied Chemistry. - : Walter de Gruyter GmbH. - 0033-4545 .- 1365-3075. ; 78:10, s. 1803-1822
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Tidskriftsartikel (refereegranskat)abstract
- In this article, we review the possibility of combining conjugated polymers with nanometer-scale devices (nanodevices), in order to introduce the properties associated with conjugated polymers into such nanodevices. This approach envisages combining the highly topical disciplines of polymer electronics and nanoelectronics to engender a new subdirection of polymer nanoelectronics, which can serve as a tool to probe the behavior of polymer molecules at the nanometer/molecular level, and contribute to clarifying transport mechanisms in conjugated polymers. In this study, we exemplify this combination, using a family of linear and conjugated polymers, poly(p-phenylene-ethynylene)s (PPEs) with thiolacetate-functionalized end groups.
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| 2. |
- Liu, Yongsheng, et al.
(författare)
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Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis
- 2022
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Ingår i: Pharmaceutics. - : MDPI. - 1999-4923. ; 14:11
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Tidskriftsartikel (refereegranskat)abstract
- Targeted molecular radiation therapy is a promising emerging treatment modality in oncology, and peptide synthesis may shorten the time to reach the clinical stage. In this study, we have explored Chemo-Enzymatic Peptide Synthesis, or CEPS, as a new means of producing a therapeutic HER2 targeted Affibody((R)) molecule, comprising a C-terminal albumin binding domain (ABD) for half-life extension and a total length of 108 amino acids. In addition, a DOTA moiety could be incorporated at N-terminus directly during the synthesis step and subsequently utilized for site-specific radiolabeling with the therapeutic radionuclide Lu-177. Retained thermodynamic stability as well as retained binding to both HER2 and albumin was verified. Furthermore, HER2 binding specificity of the radiolabeled Affibody molecule was confirmed by an in vitro saturation assay showing a significantly higher cell-bound activity of SKOV-3 (high HER2 expression) compared with BxPC3 (low HER2 expression), both in the presence and absence of HSA. In vivo evaluation in mice bearing HER2 expressing xenografts also showed specific tumor targeting as well as extended time in circulation and reduced kidney uptake compared with a HER2 targeted Affibody molecule without the ABD moiety. To conclude, we have demonstrated that CEPS can be used for production of Affibody-fusion molecules with retained in vitro and in vivo functionality.
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| 3. |
- Rothhämel, Malte, et al.
(författare)
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On Comfort in Cycle Carriers for Child Transport
- 2023
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Konferensbidrag (refereegranskat)abstract
- This study investigated the effects of load case (varying ex-tra load in addition to a single passenger) and tyre pressure (50, 200, 400kPa) on the whole-body vibration of children being transported in a cyclecarrier. The experiments were performed on a special test bed designedfor this purpose. Since previous work indicated non-linear influence ofthe tyres, static and dynamic tyre stiffness were measured separately.Overall, vibration total values were in a similar level as the results ofprevious on road experiments. The tyres seemed to have some eigenfre-quency that was rather independent of the vertical load but affected thepattern of the vibration experienced by the carrier passengers.
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| 4. |
- Xiao, Kai, et al.
(författare)
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Photoelectrical characteristics of a C/CNx multiwalled nanotube
- 2007
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Ingår i: Advanced Functional Materials. - : Wiley. - 1616-301X .- 1616-3028. ; 17:15, s. 2842-2846
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Tidskriftsartikel (refereegranskat)abstract
- A nanotube diode fabricated from a single C/CNx multiwalled nanotube exhibits a large photocurrent and a large photovoltage under illumination. The current-voltage (I-V) characteristics of the diode indicate a clear rectification effect. By comparing the I-V characteristics of C, CNx, and C/CNx nanotube diodes, we show that the rectifying characteristics of the C/CNx diode arises from the molecular junction formed at the C/CNx interface where the C and CNx segments are chemically bonded. External radiation photochernically generates electrons and holes in the C/CNx nanotube, producing a large photocurrent because of the influence of the strong electric field in the vicinity of the C/CNx junction. These unique photoresponsive characteristics of C/CNx, nanotube junction diodes points to potential applications such as photovoltaic devices and photodiodes.
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| 5. |
- Yu, Xianbin, et al.
(författare)
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Preface
- 2024
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Ingår i: Journal of Physics. - : IOP Publishing.
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Konferensbidrag (refereegranskat)
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