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- Bannai, Hideo, et al.
(författare)
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HypothesisCreator: Concepts for Accelerating the Computational Knowledge Discovery Process
- 2001
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- We summarize and discuss the work accomplished through the HypothesisCreator project, an ongoing effort whose aim is to develop systematic methods to accelerate the computational knowledge discovery process.A novel approach to describe the knowledge discovery process, focusing on a generalized form of attribute called view, is presented. It is observed that the process of knowledge discovery can, in fact, be modeled as the design, generation, use, and evaluation of views, asserting that views are the fundamental building blocks in the discovery process. Also, we note that the trial-and-error cycle inherent in any knowledge discovery process, can be formulated as the composing and decomposing of views. To assist this cycle, a programming language called VML (View Modeling Language) was designed, providing facilities for this purpose. Following this view oriented perspective, we describe our approach to the problem of characterizing N-terminal protein sorting signals in which we have obtained significant results.
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- Hudson, Thomas J., et al.
(författare)
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International network of cancer genome projects
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7291, s. 993-998
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Tidskriftsartikel (refereegranskat)abstract
- The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
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