| 1. |
- Adriani, O., et al.
(författare)
-
Design of an Antimatter Large Acceptance Detector In Orbit (ALADInO)
- 2022
-
Ingår i: Instruments. - : MDPI AG. - 2410-390X. ; 6:2
-
Tidskriftsartikel (refereegranskat)abstract
- A new generation magnetic spectrometer in space will open the opportunity to inves-tigate the frontiers in direct high-energy cosmic ray measurements and to precisely measure the amount of the rare antimatter component in cosmic rays beyond the reach of current missions. We propose the concept for an Antimatter Large Acceptance Detector In Orbit (ALADInO), designed to take over the legacy of direct measurements of cosmic rays in space performed by PAMELA and AMS-02. ALADInO features technological solutions conceived to overcome the current limi-tations of magnetic spectrometers in space with a layout that provides an acceptance larger than 10 m2 sr. A superconducting magnet coupled to precision tracking and time-of-flight systems can provide the required matter–antimatter separation capabilities and rigidity measurement resolution with a Maximum Detectable Rigidity better than 20 TV. The inner 3D-imaging deep calorimeter, designed to maximize the isotropic acceptance of particles, allows for the measurement of cosmic rays up to PeV energies with accurate energy resolution to precisely measure features in the cosmic ray spectra. The operations of ALADInO in the Sun–Earth L2 Lagrangian point for at least 5 years would enable unique revolutionary observations with groundbreaking discovery poten-tials in the field of astroparticle physics by precision measurements of electrons, positrons, and antiprotons up to 10 TeV and of nuclear cosmic rays up to PeV energies, and by the possible unam-biguous detection and measurement of low-energy antideuteron and antihelium components in cosmic rays.
|
|
| 2. |
- Laure, Erwin, et al.
(författare)
-
Programming the Grid using gLite
- 2006
-
Ingår i: Computational Methods in Science and Technology. - 1505-0602. ; 12:1, s. 33-45
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The past few years have seen the creation of the first production level Grid infrastructures that offer their users a dependableservice at an unprecedented scale. Depending on the flavor of middleware services these infrastructures deploy (for instance Condor,gLite, Globus, UNICORE, to name only a few) different interfaces to program the Grid infrastructures are provided. Despite ongoingefforts to standardize Grid service interfaces, there are still significant differences in how applications can interface to a Grid infrastructure.In this paper we describe the middleware (gLite) and services deployed on the EGEE Grid infrastructure and explain how applicationscan interface to them.
|
|
| 3. |
- Laure, Erwin, et al.
(författare)
-
Programming the grid with glite
- 2006
-
Ingår i: Computational Methods in Science and Technology. - 1505-0602. ; 12:1, s. 33-45
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The past few years have seen the creation of the first production level Grid infrastructures that offer their users a dependable service at an unprecedented scale. Depending on the flavor of middleware services these infrastructures deploy (for instance Condor, gLite, Globus, UNICORE, to name only a few) different interfaces to program the Grid infrastructures are provided. Despite ongoing efforts to standardize Grid service interfaces, there are still significant differences in how applications can interface to a Grid infrastructure. In this paper we describe the middleware (gLite) and services deployed on the EGEE Grid infrastructure and explain how applications can interface to them.
|
|
| 4. |
- Pasquali, D., et al.
(författare)
-
BROX haploinsufficiency in familial nonmedullary thyroid cancer
- 2021
-
Ingår i: Journal of Endocrinological Investigation. - : Springer Science and Business Media LLC. - 0391-4097 .- 1720-8386. ; 44, s. 165-171
-
Tidskriftsartikel (refereegranskat)abstract
- Background The familial nonmedullary thyroid cancer (FNMTC) is suspected to be a Mendelian condition in up to 3-8% of thyroid cancers. The susceptibility chromosomal loci and genes of 95% of FNMTC cases remain to be characterized. The inheritance of FNMTC appears to be autosomal dominant with incomplete penetrance and variable expressivity. The finding of the causative gene of FNMTC and the identification of patients at risk that need genetic testing were our aim. Methods We analyzed by whole-exome sequencing patients and non-affected relatives of five families with at least two family members affected by papillary thyroid cancer, selecting for new or extremely rare variants with predicted pathogenic value. Results A family showed, in all three affected members, a new loss-of-function variant (frameshift deletion) in BROX gene at 1q41 that was absent from all internal and external databases. In a second family with three affected relatives, we found an additional new BROX variant. The smaller families presented no variants in BROX or in the other causative genes studied. Conclusions BROX could be a new causative gene for FNMTC. Variants in BROX may result in the haploinsufficiency of a key gene involved in the morphogenesis of MVBs, in the endosomal sorting of cargo proteins, and in EGFR. Functional studies are needed to support this result. The thorough genomic analysis by NGS in all families with three or more affected members should become a routine approach to obtain a comprehensive genetic view and find confirmative second cases.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Ahrén, Bo, et al.
(författare)
-
Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men.
- 2009
-
Ingår i: European Journal of Clinical Nutrition. - : Springer Science and Business Media LLC. - 1476-5640 .- 0954-3007. ; Sep 3, s. 778-786
-
Tidskriftsartikel (refereegranskat)abstract
- Background/Objectives:Dietary addition of either conjugated linoleic acid (CLA) or n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) has been shown to alter adiposity and circulating lipids, risk markers of cardiovascular diseases. However, CLA may decrease insulin sensitivity, an effect that may be reversed by n-3 LC-PUFA. Thus, the potential of CLA plus n-3 LC-PUFA to affect insulin secretion and sensitivity in non-diabetic young and old, lean and obese subjects was tested.Subjects/Methods:CLA (3 g daily) plus n-3 LC-PUFA (3 g daily) or control oil (6 g daily) was given to lean (n=12; BMI 20-26 kg/m(2)) or obese (n=10; BMI 29-35 kg/m(2)) young (20-37 years old) or lean (n=16) or obese (n=11) older men (50-65 years) for 12 weeks. The study had a double-blind, placebo-controlled randomized crossover design, and primary end points were insulin secretion and sensitivity during a standardized meal test, evaluated by modeling glucose, insulin and C-peptide data.Results:The combination was well tolerated. There was no significant difference in fasting levels of glucose, insulin or C-peptide after CLA/n-3 LC-PUFA treatment compared with control oil. Neither insulin secretion nor estimated sensitivity was affected by CLA/n-3 LC-PUFA in lean or obese young subjects or in older lean subjects. However, in older obese subjects, estimated insulin sensitivity was reduced with CLA/n-3 LC-PUFA compared with control (P=0.024).Conclusions:The results do not support beneficial effects of CLA/n-3 LC-PUFA for beta-cell dysfunction or insulin resistance in humans but suggest that insulin sensitivity in older obese subjects is reduced.European Journal of Clinical Nutrition advance online publication, 3 September 2008; doi:10.1038/ejcn.2008.45.
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
- Gomes, J., et al.
(författare)
-
An overview of project COMPOUND: Cooperative communications and positioning in mobile underwater networks
- 2012
-
Ingår i: 2012 Future Network and Mobile Summit, FutureNetw 2012. - 9781905824304 ; , s. Article number6294172-
-
Konferensbidrag (refereegranskat)abstract
- One of the challenges faced by future networks is to integrate heterogeneous segments whose protocols are optimized for very different conditions. This work provides an overview of project COMPOUND, which tackles problems in this class to interface an underwater acoustic network comprising both static and mobile nodes to the Internet. The main goal is to create value and foster new applications in a niche but strategically important area by making the data and assets in the network easily available to a wide community. This will reduce the time, effort, and cost needed to customize the network to suit a specific need. A key insight in COMPOUND is to extensively exploit knowledge of node positions, including submerged ones with no access to GPS, to configure the network parameters at multiple levels, from the Internet gateway down to a node's physical layer. In turn, positioning is derived from observed data traffic on the network and collaborative exchanges between nodes, resulting in a system that tightly integrates positioning and communications. This paper discusses the proposed approach within the scope of current research on underwater acoustic communications and networking, describes application scenarios, envisaged technical solutions, planned developments, and identifies some of the possible impacts of this work. © 2012 IIMC Ltd.
|
|
| 15. |
- Hira, A., et al.
(författare)
-
Shifting to Circular Manufacturing in the Global South : Challenges and Pathways
- 2022
-
Ingår i: Journal of Developing Societies. - : SAGE Publications. - 0169-796X .- 1745-2546. ; 38:3, s. 310-335
-
Tidskriftsartikel (refereegranskat)abstract
- As the Global South shifts towards increased manufacturing, the negative effects on climate change and environmental pollution raise serious concerns. These global effects are increasingly felt locally, as reflected in health surveys throughout the Global South. The world cannot afford to wait for a natural development process to take place in which rising incomes might curb pollution. This article examines the challenges of reforming manufacturing in the Global South towards more sustainable practices. It also focuses on the lessons of the Sustainable Manufacturing and Environmental Pollution Program (SMEP) which has funded a series of environmental improvement projects across sub-Saharan Africa and South Asia aimed at reducing pollution in the manufacturing process. The lessons learned from these projects include the need to improve the tracking of the negative effects of the environmental damages caused by manufacturing and analyze the manufacturing supply chain processes to better identify potential points of intervention; as well as the need for more external financial and technical resources to expand these projects.
|
|
| 16. |
- Lindgren, Ola, et al.
(författare)
-
Incretin Effect after Oral Amino Acid Ingestion in Humans.
- 2015
-
Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 100:3, s. 1172-1176
-
Tidskriftsartikel (refereegranskat)abstract
- Context: The incretin effect is the augmented insulin secretion by oral versus intravenous glucose at matching glucose levels. We previously demonstrated an augmented insulin secretion when fat is given orally rather than intravenously, suggesting an incretin effect also after fat. However, whether there is an incretin effect is also present after amino acid ingestion is not known. Objective: To explore insulin secretion and islet hormones after oral and intravenous amino acid administration at matched total amino acid concentrations in healthy subjects. Design: Amino acid mixture (Vaminolac(R)) was administered orally or intravenously at a rate resulting in matching total amino acid concentrations to twelve male volunteers with age 22.5±1.4 yr and BMI 22.4±1.4 kg/m(2), who had no history of diabetes. Main outcome measures: Area under the 120 min curve (AUC) for insulin, C-peptide, glucagon, intact and total glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) and insulin secretory rate and insulin clearance. Results: Insulin, C-peptide and glucagon levels increased after both oral and intravenous administration, but insulin secretion was 25% higher after oral than after intravenous amino acid challenges (P=0.006), whereas there was no significant difference in the glucagon response. Intact and total GIP rose after oral but not after intravenous amino acid administration, whereas intact and total GLP-1 levels did not change significantly in either test. Conclusion: Oral amino acid mixture ingestion elicits a stronger insulin secretory response than intravenous amino acid at matching amino acid levels and that this is associated with increased GIP level, suggesting that an incretin effect exists also after oral amino acids, possibly mediated by GIP.
|
|
| 17. |
- Lindgren, Ola, et al.
(författare)
-
Incretin Hormone and Insulin Responses to Oral Versus Intravenous Lipid Administration in Humans.
- 2011
-
Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 96, s. 2519-2524
-
Tidskriftsartikel (refereegranskat)abstract
- Context: The incretin effect is responsible for the higher insulin response to oral glucose than to iv glucose at matching glucose levels. It is not known whether this effect is restricted to glucose only. Objective: The aim of the study was to examine whether insulin and incretin hormone responses are higher after oral vs. iv challenge of a lipid emulsion with matching triglyceride levels in humans. Design, Settings, and Participants: A lipid emulsion (Intralipid) was administered orally (3 ml/kg) or iv (variable infusion rates to match triglyceride levels after oral ingestion) in healthy lean males (n = 12) at a University Clinical Research Unit. Samples were collected during 300 min. Main Outcome Measures: We measured the suprabasal area under the curve for insulin, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and the insulin secretory rate based on C-peptide levels by deconvolution. Results: Triglyceride levels increased similarly after oral and iv lipid; also, glucose and free fatty acid levels were similar in the two tests. Oral lipid elicited a clear insulin and C-peptide response, whereas no insulin or C-peptide responses were observed during iv lipid. Total and intact GIP and GLP-1 levels both increased after oral lipid administration but were not significantly altered after iv lipid. Conclusions: At matching triglyceride levels and with no difference in glucose and free fatty acid levels, oral lipid ingestion but not iv lipid infusion elicits a clear insulin response in association with increased GIP and GLP-1 concentrations. This may suggest that the incretin hormones also contribute to the islet response to noncarbohydrate nutrients.
|
|
| 18. |
- Sanches Pereira, Alessandro, 1971-, et al.
(författare)
-
Fostering local sustainable development in Tanzania by enhancing linkages between tourism and small-scale agriculture
- 2017
-
Ingår i: Journal of Cleaner Production. - : Elsevier. - 0959-6526 .- 1879-1786. ; :162, s. 1567-1581
-
Tidskriftsartikel (refereegranskat)abstract
- Tourism and agriculture are important contributors to the development of local economies. Many developing nations that are now experiencing rapid tourism growth have agrarian societies and tourism is the first or second source of export earnings. In this context, the main objective of this study is to identify what are the main challenges for horticultural value chains to effectively benefit from tourism and foster sustainable development in the United Republic of Tanzania. Our results are based on pro-poor tourism, which is an approach that aims at generating net benefits for the poor, including unlocking opportunities by building a more supportive policy and planning framework. The study concludes that tourism and agriculture have an important contribution to make to local development in Tanzania. However, horticultural supply chains face a number of constraints that hold back growth and competitiveness in reaching the local tourism industry. These constraints can be divided into two main categories: lack of direct communication channels; and bottlenecks or inefficiencies in the supply chain.
|
|
