| 1. |
|
|
| 2. |
- Bousquet, J, et al.
(författare)
-
Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
- 2020
-
Ingår i: Clinical and translational allergy. - : Wiley. - 2045-7022. ; 10:1, s. 58-
-
Tidskriftsartikel (refereegranskat)abstract
- There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
|
|
| 3. |
|
|
| 4. |
- Bousquet, J., et al.
(författare)
-
Building Bridges for Innovation in Ageing : Synergies between Action Groups of the EIP on AHA
- 2017
-
Ingår i: The Journal of Nutrition, Health & Aging. - : Springer Nature. - 1279-7707 .- 1760-4788. ; 21:1, s. 92-104
-
Tidskriftsartikel (refereegranskat)abstract
- The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
|
|
| 5. |
|
|
| 6. |
- Kampessis, G, et al.
(författare)
-
Prospective Study on the Effectiveness of Low-Laser Therapy in the Treatment of Tinnitus
- 2009
-
Ingår i: Skull base. - : Georg Thieme Verlag. - 1052-1453 .- 1532-0065 .- 1531-5010. ; 19:S 02
-
Tidskriftsartikel (refereegranskat)abstract
- Background and Aim: It is estimated that 10–15% of the general population suffers from tinnitus, including 60% of all otologic patients. Quality of life is reportedly affected in approximately 0.5% of tinnitus patients. The aim of this study is to investigate the role of low-laser therapy in alleviating the symptoms of tinnitus.Material and Methods: Seventeen tinnitus patients (8 men, 9 women) were included in the study. Tinnitus was identified by the patients either as their sole complaint, or as symptom within the context of other otologic diseases. A 0–5 Visual Analogue Scale (VAS) was used to personally quantify the severity of patients' symptoms. Treatment included the use of an external laser beam in the periauricular area and the external auditory canal, which was produced either by a GaAlAs (808 nm, 450 mW), or by a GaAs (904 nm, 240 mW) laser, for 4 and 2 minutes, respectively. The mean number of sessions for each patient was 17, and the mean duration of therapy was 4 weeks.Results: With regard to the severity of symptoms, the pretreatment mean score was 4.3, and the respected number after the intervention was 3.2. There was a consistent trend toward symptom improvement; however, the results were not statistically significant due to the small sample size. No side effects or deterioration of symptoms was reported.Conclusion: Low-laser therapy does seem to have some effect in alleviating tinnitus. However, additional studies are necessary to prove the actual efficacy of this treatment mode and to establish superior outcomes compared with placebo.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
- Papanikolaou, E., et al.
(författare)
-
Implicit business model effects of DLT adoption
- 2021
-
Ingår i: Procedia CIRP. - : Elsevier BV. - 2212-8271. ; , s. 298-304
-
Konferensbidrag (refereegranskat)abstract
- The significance of supply chain collaboration, communication and data exchange along with the importance of the relationships established among interconnected parties in a digital connected world, indicates the power of Distributed Ledger Technology (DLT) to transform the business model. In our study we set out to advance our understanding on how DLT impacts the business model. Since DLT is in its primitive stage of development, most studies focus into the implementation aspect of the technology and limited research has been done into the business model implications. Our research closes that knowledge gap in the literature by answering the question of "What are the secondary effects in business model that stem from DLT adoption?"Due to the inherent characteristics of the DLT, in respect to its network facet and the network effects created, we argue for a business ecosystem approach for our research. The main contributions of this paper are twofold. It presents implicit effects on business model beyond the direct trust and data openness aspects, and it also provides managers and scholars a process model for assessing how each implicit effect impacts the various business model dimensions.
|
|
| 14. |
|
|
| 15. |
- Poulios, A., et al.
(författare)
-
Post-Game High Protein Intake May Improve Recovery of Football-Specific Performance during a Congested Game Fixture: Results from the PRO-FOOTBALL Study
- 2018
-
Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 10:4
-
Tidskriftsartikel (refereegranskat)abstract
- The effects of protein supplementation on performance recovery and inflammatory responses during a simulated one-week in-season microcycle with two games (G1, G2) performed three days apart were examined. Twenty football players participated in two trials, receiving either milk protein concentrate (1.15 and 0.26 g/kg on game and training days, respectively) (PRO) or an energy-matched placebo (1.37 and 0.31 g/kg of carbohydrate on game and training days, respectively) (PLA) according to a randomized, repeated-measures, crossover, double-blind design. Each trial included two games and four daily practices. Speed, jump height, isokinetic peak torque, and muscle soreness of knee flexors (KF) and extensors (KE) were measured before G1 and daily thereafter for six days. Blood was drawn before G1 and daily thereafter. Football-specific locomotor activity and heart rate were monitored using GPS technology during games and practices. The two games resulted in reduced speed (by 3-17%), strength of knee flexors (by 12-23%), and jumping performance (by 3-10%) throughout recovery, in both trials. Average heart rate and total distance covered during games remained unchanged in PRO but not in PLA. Moreover, PRO resulted in a change of smaller magnitude in high-intensity running at the end of G2 (75-90 min vs. 0-15 min) compared to PLA (P = 0.012). KE concentric strength demonstrated a more prolonged decline in PLA (days 1 and 2 after G1, P = 0.014-0.018; days 1, 2 and 3 after G2, P = 0.016-0.037) compared to PRO (days 1 after G1, P = 0.013; days 1 and 2 after G2, P = 0.014-0.033) following both games. KF eccentric strength decreased throughout recovery after G1 (PLA: P=0.001-0.047-PRO: P =0.004-0.22) in both trials, whereas after G2 it declined throughout recovery in PLA (P = 0.000-0.013) but only during the first two days (P = 0.000-0.014) in PRO. No treatment effect was observed for delayed onset of muscle soreness, leukocyte counts, and creatine kinase activity. PRO resulted in a faster recovery of protein and lipid peroxidation markers after both games. Reduced glutathione demonstrated a more short-lived reduction after G2 in PRO compared to PLA. In summary, these results provide evidence that protein feeding may more efficiently restore football-specific performance and strength and provide antioxidant protection during a congested game fixture.
|
|
| 16. |
|
|
| 17. |
- Stathakis, S, et al.
(författare)
-
Monte Carlo Based Dose Verification for Serial Tomotherapy
- 2007
-
Ingår i: Proceedings in 49th AAPM Annual Meeting, Minneapolis, Minnesota, USA, July 22-26, 2007. - : Wiley.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Purpose: To develop a Monte Carlo model to verify the final dose distributions and monitor units for serial tomotherapy plans developed and delivered using the Peacock system (Corvus Treatment Planning System and MIMiC collimator, Nomos Corp., Sewickley, PA). Materials and methods: The Peacock system delivers the dose to the patient using arc therapy. The treatment plan is created in Corvus were sinograms are created for each arc in order to dictate the state of each of the MIMiC leaves at different locations along the arc. In-house functions were written in Matlab (Mathworks Inc., Natick, MA) to decode these sinograms. A simple three-field plan (three gantry positions), as well as full patient treatment plans were simulated using our Monte Carlo model and the same plans were delivered using the Peacock system in solid water. Films were placed in the solid water phantom in order to measure the dose distribution for comparison against the Monte Carlo calculations. Matlab functions were written to convert the Monte Carlo output into a format RIT113 (RIT Inc., Colorado Springs, CO) could read. This allowed us to co-register the calculated dose maps and the measured ones in order to compare the two. Results: The Monte Carlo calculated dose distribution from the complete arc therapy in solid water phantom was compared against film measurements. The agreement was within 2%. The comparison between Monte Carlo results and Corvus calculated dose distribution revealed that Corvus would fail to accurately compute the dose in the region where inhomogeneities were present. Conclusions: Based on the agreement between Monte Carlo and measurements we can use the Monte Carlo system as an independent quality assurance tool in order to verify dose distributions and MUs per arc computed by the Corvus.
|
|
| 18. |
|
|
| 19. |
- Su, F-C, et al.
(författare)
-
Assessing four-dimensional radiotherapy planning and respiratory motion-induced dose difference based on biologically effective uniform dose.
- 2009
-
Ingår i: Technology in Cancer Research & Treatment. - : SAGE Publications. - 1533-0346 .- 1533-0338. ; 8:3, s. 187-200
-
Tidskriftsartikel (refereegranskat)abstract
- Four-dimensional (4D) radiotherapy is considered as a feasible and ideal solution to accommodate intra-fractional respiratory motion during conformal radiation therapy. With explicit inclusion of the temporal changes in anatomy during the imaging, planning, and delivery of radiotherapy, 4D treatment planning in principle provides better dose conformity. However, the clinical benefits of developing 4D treatment plans in terms of tumor control rate and normal tissue complication probability as compared to other treatment plans based on CT images of a fixed respiratory phase remains mostly unproven. The aim of our study is to comprehensively evaluate 4D treatment planning for nine lung tumor cases with both physical and biological measures using biologically effective uniform dose (D =) together with complication-free tumor control probability, P+. Based on the examined lung cancer patients and PTV margin applied, we found similar but not identical curves of DVH, and slightly different mean doses in tumor (up to 1.5%) and normal tissue in all cases when comparing 4D, P0%, and P50% plans. When it comes to biological evaluations, we did not observe definitively PTV size dependence in P+ among these nine lung cancer patients with various sizes of PTV. Moreover, it is not necessary that 4D plans would have better target coverage or higher P+ as compared to a fixed phase IMRT plan. However, on the contrary to significant deviations in P+ (up to 14.7%) observed if delivering the IMRT plan made at end-inhalation incorrectly at end-exhalation phase, we estimated the overall P+, PB, and PI for 4D composite plans that have accounted for intra-fractional respiratory motion.
|
|
| 20. |
|
|
