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- Marchand, M, et al.
(författare)
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Immunisation of metastatic cancer patients with MAGE-3 protein combined with adjuvant SBAS-2 : A clinical report
- 2003
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Ingår i: European Journal of Cancer. - 0959-8049 .- 1879-0852. ; 39:1, s. 70-77
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Tidskriftsartikel (refereegranskat)abstract
- Fifty-seven patients with MAGE-3-positive measurable metastatic cancer, most of them with melanoma, were vaccinated with escalating doses of a recombinant MAGE-3 protein combined with a fixed dose of the immunological adjuvant SBAS-2, which contained MPL and QS21. The immunisation schedule included 4 intramuscular (i.m.) injections at 3-week intervals. Patients whose tumour stabilised or regressed after 4 vaccinations received 2 additional vaccinations at 6-week intervals. The vaccine was generally well tolerated. Among the 33 melanoma patients who were evaluable for tumour response, we observed 2 partial responses, 2 mixed responses and 1 stabilisation. Time to progression in these 5 patients varied from 4 to 29 months. In addition, a partial response lasting 10 months was observed in 1 of the 3 metastatic bladder cancer patients included. None of the tumour responses described above involved visceral metastases. Immunological responses to the vaccine will be reported separately. ⌐ 2002 Elsevier Science Ltd. All rights reserved.
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| 3. |
- Noardo, F., et al.
(författare)
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GeoBIM Benchmark 2019 : Intermediate results
- 2019. - 4/W15
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Ingår i: International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences - ISPRS Archives. ; 42, s. 47-52
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Konferensbidrag (refereegranskat)abstract
- An investigation into the implementation state of open standards in software is currently ongoing through the ISPRS/EuroSDR 'GeoBIM benchmark 2019' initiative, which kicked off earlier this year. The benchmark activity provides a way of assessing and comparing the functionality of different software packages in GIS and BIM in terms of their ability to handle standardised data (IFC and CityGML) and undertake various tasks using this data. Approximately 65 people have registered to participate so far, with participants from a wide range of backgrounds and proposing to test a variety of software packages. This confirms that the issues under investigation are of interest, and also meets the wider benchmark aim of having a variety of participants, since the project is conceived as using a bottom-up approach with cross-disciplinary and cross-expertise participation. While full benchmark results are not due to be submitted until later this year, interim results have highlighted a number of common issues across multiple software packages, and a web meeting for participants held in July 2019 also led to some improvements in how the benchmark results are being captured.
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| 4. |
- Noardo, F., et al.
(författare)
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INTEGRATING EXPERTISES and AMBITIONS for DATA-DRIVEN DIGITAL BUILDING PERMITS - The EUNET4DBP
- 2020. - 4/W1
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Ingår i: International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences. - 1682-1750. ; 44, s. 103-110
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Konferensbidrag (refereegranskat)abstract
- The digitalization of the process for building permit (involving the use of 3D information systems) is seen as a priority in a wide part of the world. Since it is a very multidisciplinary use case, involving a variety of stakeholders tackling complex issues and topics, some of them joined their efforts and skills in the European Network for Digital Building Permit. The initial activity of the network, after a review of on-going experiences, was a workshop to share knowledge about the topics involved and to identify the main ambitions of the network with respect to three pillars (i.e. Process - Rules and Requirements - Technology) and the related requirements. It was achieved through a collective brainstorming activity guided by digital tools, whose results were further analysed in a post-processing phase. Such results are presented in this paper and will be the base for planning the future network activity.
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| 5. |
- Stoter, Stein K.F., et al.
(författare)
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Critical time-step size analysis and mass scaling by ghost-penalty for immersogeometric explicit dynamics
- 2023
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Ingår i: Computer Methods in Applied Mechanics and Engineering. - : Elsevier. - 0045-7825 .- 1879-2138. ; 412
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Tidskriftsartikel (refereegranskat)abstract
- In this article, we study the effect of small-cut elements on the critical time-step size in an immersogeometric explicit dynamics context. We analyze different formulations for second-order (membrane) and fourth-order (shell-type) equations, and derive scaling relations between the critical time-step size and the cut-element size for various types of cuts. In particular, we focus on different approaches for the weak imposition of Dirichlet conditions: by penalty enforcement and with Nitsche's method. The conventional stability requirement for Nitsche's method necessitates either a cut-size dependent penalty parameter, or an additional ghost-penalty stabilization term. Our findings show that both techniques suffer from cut-size dependent critical time-step sizes, but the addition of a ghost-penalty term to the mass matrix serves to mitigate this issue. We confirm that this form of ‘mass-scaling’ does not adversely affect error and convergence characteristics for a transient membrane example, and has the potential to increase the critical time-step size by orders of magnitude. Finally, for a prototypical simulation of a Kirchhoff–Love shell, our stabilized Nitsche formulation reduces the solution error by well over an order of magnitude compared to a penalty formulation at equal time-step size.
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