| 1. |
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| 2. |
- Álvarez-Muñiz, Jaime, et al.
(author)
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The Giant Radio Array for Neutrino Detection (GRAND) : Science and design
- 2020
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In: Science China Physics, Mechanics & Astronomy. - : Springer Science and Business Media LLC. - 1674-7348 .- 1869-1927. ; 63:1
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Research review (peer-reviewed)abstract
- The Giant Radio Array for Neutrino Detection (GRAND) is a planned large-scale observatory of ultra-high-energy (UHE) cosmic particles, with energies exceeding 108 GeV. Its goal is to solve the long-standing mystery of the origin of UHE cosmic rays. To do this, GRAND will detect an unprecedented number of UHE cosmic rays and search for the undiscovered UHE neutrinos and gamma rays associated to them with unmatched sensitivity. GRAND will use large arrays of antennas to detect the radio emission coming from extensive air showers initiated by UHE particles in the atmosphere. Its design is modular: 20 separate, independent sub-arrays, each of 10000 radio antennas deployed over 10000 km(2). A staged construction plan will validate key detection techniques while achieving important science goals early. Here we present the science goals, detection strategy, preliminary design, performance goals, and construction plans for GRAND.
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| 3. |
- Sun, Xiaoming, et al.
(author)
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Adjustable hardness of hydrogel for promoting vascularization and maintaining sternness of stem cells in skin flap regeneration
- 2018
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In: Applied Materials Today. - : Elsevier. - 2352-9407. ; 13, s. 54-63
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Journal article (peer-reviewed)abstract
- The matrix mechanical stiffness of biomaterials plays an important role in the pluripotency and biological function of stem cells in the microenvironment. It is a key step to adjust the stiffness of biomaterials for inducing stem cells to promote vascularization in order to promote damaged tissue repair. In this study, we transplant adipose derived stem cells (ADSCs) within an in situ forming dextran hydrogel with controllable mechanical strength formed by cross-linking glycidyl methacrylate derivatized dextran and dithiothreitol, which can regulate the stemness and biological functions of stem cells. We show that softer dextran hydrogel can better maintain stemness markers expression of ADSCs, and significantly stimulate ADSCs to secrete angiogenic factors. The ADSCs-encapsulated hydrogel distinctly promote the skin flap survival compared to direct cell injection. Bioluminescence imaging analysis shows that in situ forming dextran hydrogel can improve cells retention, and postmortem analysis reveals that the transplanted ADSCs with hydrogel can promote vascularization. These results support the use of injectable dextran hydrogel for skin ischemia tissue regeneration. (C) 2018 Elsevier Ltd. All rights reserved.
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| 4. |
- Liu, Zhigang, et al.
(author)
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Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment
- 2020
-
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 11:1, s. 855-
-
Journal article (peer-reviewed)abstract
- Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene expression in hippocampus, re-structures the gut microbiota, and improves microbial metabolites that are related to cognitive function. Moreover, strong connections are observed between IF affected genes, microbiota and metabolites, as assessed by integrative modelling. Removing gut microbiota with antibiotics partly abolishes the neuroprotective effects of IF. Administration of 3-indolepropionic acid, serotonin, short chain fatty acids or tauroursodeoxycholic acid shows a similar effect to IF in terms of improving cognitive function. Together, our study purports the microbiota-metabolites-brain axis as a mechanism that can enable therapeutic strategies against metabolism-implicated cognitive pathophysiologies.
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| 5. |
- Zhang, Guoqing, et al.
(author)
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Extensive and drastically different alpine lake changes on Asia's high plateaus during the past four decades
- 2017
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In: Geophysical Research Letters. - 0094-8276. ; 44:1, s. 252-260
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Journal article (peer-reviewed)abstract
- Asia's high plateaus are sensitive to climate change and have been experiencing rapid warming over the past few decades. We found 99 new lakes and extensive lake expansion on the Tibetan Plateau during the last four decades, 1970–2013, due to increased precipitation and cryospheric contributions to its water balance. This contrasts with disappearing lakes and drastic shrinkage of lake areas on the adjacent Mongolian Plateau: 208 lakes disappeared and 75% of the remaining lakes have shrunk. We detected a statistically significant coincidental timing of lake area changes in both plateaus, associated with the climate regime shift that occurred during 1997/1998. This distinct change in 1997/1998 is thought to be driven by large-scale atmospheric circulation changes in response to climate warming. Our findings reveal that these two adjacent plateaus have been changing in opposite directions in response to climate change. These findings shed light on the complex role of the regional climate and water cycles, and provide useful information for ecological and water resource planning in these fragile landscapes.
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| 6. |
- Zhang, Zhisen, et al.
(author)
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Effects of Graphene Nanopore Geometry on DNA Sequencing
- 2014
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In: The Journal of Physical Chemistry Letters. - : American Chemical Society (ACS). - 1948-7185. ; 5:9, s. 1602-1607
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Journal article (peer-reviewed)abstract
- In this Letter we assess the effect of graphene nanopore geometries on DNA sequencing by considering DNA fragments including A, T, C, G, and 5-methylcytosine (MC) pulled out of graphene nanopores of different geometries with diameters down to similar to 1 nm. Using steered molecular dynamics simulations it is demonstrated that the bases (A, T, C, G, and MC) can be indentified at single-base resolution through the characteristic peaks on the force profile in a circular graphene nanopore but not in nanopores with other asymmetric geometries. Our study suggests that the graphene nanopore surface should be modified as symmetrically as possible in order to sequence DNA by atomic force microscopy or optical tweezers.
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| 7. |
- Zhou, Wencai, et al.
(author)
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The Role of Grain Boundaries on Ion Migration and Charge Recombination in Halide Perovskites
- 2024
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In: Small. - : WILEY-V C H VERLAG GMBH. - 1613-6810 .- 1613-6829.
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Journal article (peer-reviewed)abstract
- Grain boundaries (GBs) have a significant role in polycrystalline perovskite solar cells (PSCs). However, there is ongoing debate regarding the impact of GBs on the performance and long-term stability of PSCs. Employing the first-principles molecular dynamics for perovskites, the iodine vacancy defect migrations both in bulk and at GBs are investigated. i) The positive iodine vacancy (VI+) is found that have both lower formation energy (1.4 eV) and activation energy (0.18 eV) than those of neutral iodine vacancy (VI), statistically. It indicated the VI+ acts as the dominant migrated iodine vacancy rather than VI; ii) the iodine vacancy at GBs has approximate to 0.48 eV higher activation energy than those in bulk, which leads to the accumulation of iodine vacancy at GBs; iii) the presence of VI+ result in a 3-fold increase in charge recombination ratio at GBs, compared to pristine PSCs. Based on quantum molecular dynamics statistical results, which are consistent with experimental measurements, insights into iodine vacancy migration both at GBs and in the bulk are gained. This understanding can be valuable for defects engineering related to ion migration, in order to improve the long-term stability and promote the performance of PSCs. Understanding defects engineering related to ion migration is crucial for enhancing the long-term stability and performance of hybrid perovskite solar cells. Iodine vacancies accumulate at grain boundaries due to lower formation energy and higher migration potential barrier compared to those in the bulk, which further increase the nonradiative recombination. image
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| 8. |
- Ahmad, Mohd Riduan, et al.
(author)
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Emission Heights of Narrow Bipolar Events in a Tropical Storm over the Malacca Strait
- 2017
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In: 2017 International Conference On Electrical Engineering And Computer Science (Icecos). - : IEEE. - 9781479976751 - 9781479976768 - 9781479976744 ; , s. 305-309
-
Conference paper (peer-reviewed)abstract
- Emission heights for narrow bipolar events (NBEs) have been reported mostly from observations at mid latitudes but none have been reported from tropical regions. In this paper, we are reporting for the first time the heights of NBE emissions from a tropical storm over the Malacca Strait, a narrow water passage between the Malay Peninsula and Sumatra Island. A total of 49 positive NBEs (+NBEs) were detected from the storm. The NBE activity can be divided into two stages according to the emission heights and radar reflectivity data. The first stage (or S1) lasted for only 6 minutes, started with the first detected NBE, and produced 20 NBEs (41%). The emission heights ranged between 12.0 and 16.7 km. Radar reflectivity data showed that the storm reached maximum values at 55 dBZ within the period S1. In contrast, the second stage (S2) lasted longer (32 minutes) and produced 29 NBEs (59%). The emission heights were lower and ranged from 8.5 to 13.7 km. Radar reflectivity data showed that the storm reached maximum values at 50 dBZ within the period S2.
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| 9. |
- Baharin, Shamsul Ammar Shamsul, et al.
(author)
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Microwave radiation associated with stepped leaders of negative cloud-to-ground flashes
- 2022
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In: Atmospheric research. - : Elsevier. - 0169-8095 .- 1873-2895. ; 270
-
Journal article (peer-reviewed)abstract
- In this paper, Very-High Frequency (VHF) and microwave radiation pulses associated with stepped leader pulses (conventional breakdown) are examined. A total of 100 stepped leader pulses (SLPs) with the associated 100 quiet periods (QPs) from ten negative cloud-to-ground (CG) flashes within the reversal distance (<8 km) have been analyzed. The QP is defined as the period between two SLPs when no electrical activity within the fast antenna sensor bandwidth was detected. The measurement system is made up of fast antenna (FA) and slow antenna (SA) sensors, a VHF sensor (60 MHz center frequency with 40 MHz bandwidth), and a microwave sensor (0.97 GHz center frequency with 20 MHz bandwidth). The waveforms were sampled at 2.5 GHz (400 ps). The total durations of the SLPs and QPs were 2.648 +/- 1.152 mu s and 2.708 +/- 1.670 mu s, respectively. All microwave and VHF radiation waveforms have been detected as clear individual oscillating pulses. The key finding is that the microwave radiation can be classified into three categories based on the total number of detected individual oscillating pulses during the QP. Two microwave pulses detected during the QP (Category 1) are suggested to be associated with the electron avalanche/corona process at the tip of an existing negative leader and a space stem. The VHF pulses associated with the microwave pulses are suggested to be emitted by propagating streamers. On the other hand, a single microwave pulse detected during the QP (Category 2) is suggested to be emitted by the electron avalanche/corona process of a space stem. The VHF pulses associated with the microwave pulse are suggested to be emitted by propagating streamers. In both categories, 70% of the microwave radiation pulses have been observed to precede VHF radiation pulses with an average lead time of 0.848 +/- 1.336 mu s. The head-on collision of a downward propagating negative streamer and an upward propagating positive streamer (from space stem) emitted significant microwave radiation. A new negative leader was formed when the head-on collision took place. The microwave radiation pulses emitted by the head-on collision process were observed to precede SLPs with an average lead time of 0.423 +/- 0.378 mu s. Around 80% of the microwave radiation pulses preceded VHF radiation pulses with average lead time of 0.540 +/- 0.596 mu s. Therefore, microwave and VHF radiation pulses are suggested to be emitted by different processes of the electrical breakdown mechanism. The microwave radiation is emitted by electron avalanche/corona/head-on collision while the VHF radiation is emitted by propagating streamers.
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| 10. |
- Duan, Hongbo, et al.
(author)
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China’s adaptive response to climate change through air-conditioning
- 2023
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In: iScience. - : Elsevier BV. - 2589-0042. ; 26:3, s. 1-19
-
Journal article (peer-reviewed)abstract
- Studies have shown that the soaring demand for air conditioners in recent years is closely related to the worsening global warming; however, little evidence has been provided for China. This study uses weekly data of 343 Chinese cities to investigate how air conditioner sales respond to climate variability. We detected a U-shaped relationship between air-conditioning and temperature. An additional day with average temperature above 30°C increases weekly sales by 16.2%. Heterogeneity analysis shows that the adoption of air-conditioning is different for south and north China. By combining our estimates with shared socioeconomic pathway scenarios, we project China’s mid-century air conditioner sales and the resulting electricity demand. Under the fossil-fueled development scenario, air conditioner sales in the Pearl River Delta would rise by 71% (65.7%–87.6%) in summer. On average, the per capita electricity demand for air-conditioning will surge by 28% (23.2%–35.4%) in China by mid-century.
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| 11. |
- Guo, Jiawei, et al.
(author)
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Bimetallic Sulfides with Vacancy Modulation Exhibit Enhanced Electrochemical Performance
- 2024
-
In: Advanced Functional Materials. - 1616-3028 .- 1616-301X. ; 34:28
-
Journal article (peer-reviewed)abstract
- Transition bimetallic sulfides show significant promise for energy-related applications because of their plentiful active sites and synergistic redox activity. However, limited pore size and low-conductivity issues hinder their application. The structure of NiCo-S with rich sulfur vacancies is first predicted by density functional theory (DFT) calculations. Different sulfur vacancy concentrations are modeled by DFT calculations, and the results confirm that sulfur vacancies enhance the conductivity of the electrode material and are more beneficial for the adsorption of OH* species. It is verified by the differential charge density that the electric field formed on the surface of the electrode can lead to strong interfacial interactions by electron aggregation, which promotes electron/ion transfer kinetics. Furthermore, NiCo-S nanosheets are prepared on carbon cloth enriched with different concentrations of sulfur vacancies (denoted as NiCo-Sv-x, with x representing the concentration of sulfur vacancies) by sulfide etching NiCo-MOF and annealing under H2/Ar atmosphere. The NiCo-Sv-x electrodes obtained are applied to the cathode of supercapacitors and the anode of the oxygen evolution reaction. Through combining experimental and theoretical analysis, the effect of vacancy defect engineering on the electrochemical performance of the electrode materials is further confirmed. This work constructs transition metal sulfides with different sulfur vacancy concentrations through DFT model prediction and experimental validation, further confirming the effect of vacancy defect engineering on the electrochemical performance of electrode materials. Therefore, this modulation of sulfur vacancy concentration by vacancy defects contributes to the construction of electrode materials with excellent performance for energy applications.
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| 12. |
- Keasar, Chen, et al.
(author)
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An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12
- 2018
-
In: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 8
-
Journal article (peer-reviewed)abstract
- Every two years groups worldwide participate in the Critical Assessment of Protein Structure Prediction (CASP) experiment to blindly test the strengths and weaknesses of their computational methods. CASP has significantly advanced the field but many hurdles still remain, which may require new ideas and collaborations. In 2012 a web-based effort called WeFold, was initiated to promote collaboration within the CASP community and attract researchers from other fields to contribute new ideas to CASP. Members of the WeFold coopetition (cooperation and competition) participated in CASP as individual teams, but also shared components of their methods to create hybrid pipelines and actively contributed to this effort. We assert that the scale and diversity of integrative prediction pipelines could not have been achieved by any individual lab or even by any collaboration among a few partners. The models contributed by the participating groups and generated by the pipelines are publicly available at the WeFold website providing a wealth of data that remains to be tapped. Here, we analyze the results of the 2014 and 2016 pipelines showing improvements according to the CASP assessment as well as areas that require further adjustments and research.
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| 13. |
- Liang, Lijun, et al.
(author)
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Theoretical Evaluation on Potential Cytotoxicity of Graphene Quantum Dots
- 2016
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In: ACS Biomaterials Science & Engineering. - : AMER CHEMICAL SOC. - 2373-9878. ; 2:11, s. 1983-1991
-
Journal article (peer-reviewed)abstract
- Owing to unique morphology, ultrasmall lateral sizes, and exceptional properties, graphene quantum dots (GQDs) hold great potential in many applications, especially in the field of electrochemical biosensors, bioimaging, drug delivery, et cetera. Its biosafety and potential cytotoxicity to human and animal cells has been a growing concern in recent years. In this work, the potential cytotoxicity of GQDs was evaluated by molecular dynamics simulations. Our simulation demonstrates that small size GQDs could easily permeate into the lipid membrane in a vertical way. It is relatively difficult to permeate into the lipid membrane for GQDs that are larger than GQD61 on the nanosecond time-scale. The thickness of the POPC membrane could even be affected by the small size of GQDs. Free energy calculations revealed that the free energy barrier of GQD permeation through the lipid membrane could greatly change with the change of GQD size. Under high GQD concentration, the GQD molecules could rapidly aggregate in water but disaggregate after entering into the membrane interior. Moreover, high concentrations of GQDs could induce changes in the structure properties and diffusion properties of the lipid bilayer, and it may affect the cell signal transduction. However, GQDs with relatively small size are not large enough to mechanically damage the lipid membrane. Our results suggest that the cytotoxicity of GQDs with small size is low and may be appropriate for biomedical application.
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| 14. |
- Peng, Yanchun, et al.
(author)
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Genome-Wide Association Studies of Free Amino Acid Levels by Six Multi-Locus Models in Bread Wheat
- 2018
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In: Frontiers in Plant Science. - : FRONTIERS MEDIA SA. - 1664-462X. ; 9
-
Journal article (peer-reviewed)abstract
- Genome-wide association studies (GWAS) have been widely used to dissect the complex biosynthetic processes of plant metabolome. Most studies have used single-locus GWAS approaches, such as mixed linear model (MLM), and little is known about more efficient algorithms to implement multi-locus GWAS. Here, we report a comprehensive GWAS of 20 free amino acid (FAA) levels in kernels of bread wheat (Triticum aestivum L.) based on 14,646 SNPs by six multi-locus models (FASTmrEMMA, FASTmrMLM, ISISEM-BLASSO, mrMLM, pKWmEB, and pLARmEB). Our results showed that 328 significant quantitative trait nucleotides (QTNs) were identified in total (38, 8, 92, 45, 117, and 28, respectively, for the above six models). Among them, 66 were repeatedly detected by more than two models, and 155 QTNs appeared only in one model, indicating the reliability and complementarity of these models. We also found that the number of significant QTNs for different FAAs varied from 8 to 41, which revealed the complexity of the genetic regulation of metabolism, and further demonstrated the necessity of the multi-locus GWAS. Around these significant QTNs, 15 candidate genes were found to be involved in FAA biosynthesis, and one candidate gene (TraesCS1D01G052500, annotated as tryptophan decarboxylase) was functionally identified to influence the content of tryptamine in vitro. Our study demonstrated the power and efficiency of multi-locus GWAS models in crop metabolome research and provided new insights into understanding FAA biosynthesis in wheat.
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| 15. |
- Sabri, Muhammad Haziq Mohammad, et al.
(author)
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A study of cloud-to-ground lightning flashes initiated by fast positive breakdown
- 2022
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In: Atmospheric research. - : Elsevier. - 0169-8095 .- 1873-2895. ; 276
-
Journal article (peer-reviewed)abstract
- In this paper, we examine the initiation event of two tropical negative cloud to ground (CG) lightning flashes within reversal distance (<8 km) detected on 12 (CG1) and 24 (CG2) November 2019, respectively. The CG flashes were recorded using a fast antenna (FA), slow antenna (SA), magnetic field (B-field), and very high frequency (VHF) sensors located at two observation stations (ST1 and ST2) 13.26 km apart. The key finding is that CG1 flash was initiated by a short VHF pulse followed by a VHF burst (fast positive breakdown) while CG2 flash was initiated by a VHF burst (fast positive breakdown) not preceded by a short VHF pulse. The VHF burst was a precursor for initiation of a narrow bipolar event (NBE)-like pulse and initial electric field changes (IECs). Based on the VHF interferometer map, the VHF sources of NBE-like pulses have been propagated upward predominantly vertical. The initiation altitude, total length of the VHF sources propagation, estimated velocity of NBE-like pulse for CG1 flash were 4.5 +/- 0.5 km, 1.9-3.8 km, and 2.4 x 108 to 4.8 x 108 ms-1, respectively, and for CG2 flash were 5.1 +/- 0.8 km, 0.2-3.0 km, and 2.7 x 107 to 4.1 x 108 ms-1, respectively. It is evident that IECs process has been initiated during fast positive streamers propagation. It can be suggested that the IECs process resulted from charge transfer during a fast positive breakdown. The durations and magnitudes of IECs for CG1 flash were 248.5 mu s and 27.97 V/m, respectively, and for CG2 flash were 265.8 mu s and 2.31 V/m, respectively.
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| 16. |
- Sabri, Muhammad Haziq Mohamad, et al.
(author)
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Environmental Analysis of Quasi-Static Electric Field Changes of Tropical Lightning Flashes
- 2019
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In: Ekoloji. - 1300-1361. ; 28:107, s. 373-378
-
Journal article (peer-reviewed)abstract
- The environmental conditions leading to the bouncing-wave discharge and the subsequent electron beam remain to be investigated in more detailed future studies. The analysis of quasi-static initial electric field changes (IECs) were found at the beginning of all 24 lightning flashes detected within reversal distance (22 Negative Cloud-to-Ground (–CG) and 2 normal Intra-Cloud (IC) flashes) in a tropical storm on June 15th, 2017 close to our station in Malacca, Malaysia (2.314077° N, 102.318282° E). The IECs durations averaged 4.28 ms for –CG flashes (range 1.48 to 9.45 ms) and averaged 11.30 ms for normal ICs flashes (range 7.24 to 15.35 ms). In comparison to Florida storms, the duration of IECs for –CG and IC flashes were 0.18 ms (range 0.08 to 0.33 ms) and 1.53 ms (range 0.18 to 5.70 ms), respectively. Moreover, the magnitudes of E-change for tropical thunderstorm were 0.13 V/m (range 0.03 to 0.44 V/m) for –CG flashes and -0.20 V/m (range -0.13 to -0.27 V/m) for IC flashes. The E-change magnitudes of tropical flashes are significantly larger than Florida flashes.
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| 17. |
- Sedlacek, Ondrej, et al.
(author)
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Influence of Chain Length of Gradient and Block Copoly(2-oxazoline)s on Self-Assembly and Drug Encapsulation
- 2022
-
In: Small. - : John Wiley & Sons. - 1613-6810 .- 1613-6829. ; 18:17
-
Journal article (peer-reviewed)abstract
- Amphiphilic gradient copolymers represent a promising alternative to extensively used block copolymers due to their facile one-step synthesis by statistical copolymerization of monomers of different reactivity. Herein, an in-depth analysis is provided of micelles based on amphiphilic gradient poly(2-oxazoline)s with different chain lengths to evaluate their potential for micellar drug delivery systems and compare them to the analogous diblock copolymer micelles. Size, morphology, and stability of self-assembled nanoparticles, loading of hydrophobic drug curcumin, as well as cytotoxicities of the prepared nanoformulations are examined using copoly(2-oxazoline)s with varying chain lengths and comonomer ratios. In addition to several interesting differences between the two copolymer architecture classes, such as more compact self-assembled structures with faster exchange dynamics for the gradient copolymers, it is concluded that gradient copolymers provide stable curcumin nanoformulations with comparable drug loadings to block copolymer systems and benefit from more straightforward copolymer synthesis. The study demonstrates the potential of amphiphilic gradient copolymers as a versatile platform for the synthesis of new polymer therapeutics.
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| 18. |
- Shi, Weibo, et al.
(author)
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Optimizing Observation Plans for Identifying Faxon Fir (Abies fargesii var. Faxoniana) Using Monthly Unmanned Aerial Vehicle Imagery
- 2023
-
In: Remote Sensing. - 2072-4292. ; 15:8
-
Journal article (peer-reviewed)abstract
- Faxon fir (Abies fargesii var. faxoniana), as a dominant tree species in the subalpine coniferous forest of Southwest China, has strict requirements regarding the temperature and humidity of the growing environment. Therefore, the dynamic and continuous monitoring of Faxon fir distribution is very important to protect this highly sensitive ecological environment. Here, we combined unmanned aerial vehicle (UAV) imagery and convolutional neural networks (CNNs) to identify Faxon fir and explored the identification capabilities of multispectral (five bands) and red-green-blue (RGB) imagery under different months. For a case study area in Wanglang Nature Reserve, Southwest China, we acquired monthly RGB and multispectral images on six occasions over the growing season. We found that the accuracy of RGB imagery varied considerably (the highest intersection over union (IoU), 83.72%, was in April and the lowest, 76.81%, was in June), while the accuracy of multispectral imagery was consistently high (IoU > 81%). In April and October, the accuracy of the RGB imagery was slightly higher than that of multispectral imagery, but for the other months, multispectral imagery was more accurate (IoU was nearly 6% higher than those of the RGB imagery for June). Adding vegetation indices (VIs) improved the accuracy of the RGB models during summer, but there was still a gap to the multispectral model. Hence, our results indicate that the optimized time of the year for identifying Faxon fir using UAV imagery is during the peak of the growing season when using a multispectral imagery. During the non-growing season, RGB imagery was no worse or even slightly better than multispectral imagery for Faxon fir identification. Our study can provide guidance for optimizing observation plans regarding data collection time and UAV loads and could further help enhance the utility of UAVs in forestry and ecological research.
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| 19. |
- Suominen, Tina, et al.
(author)
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Determination of Serotonin and Dopamine Metabolites in Human Brain Microdialysis and Cerebrospinal Fluid Samples by UPLC-MS/MS : Discovery of Intact Glucuronide and Sulfate Conjugates
- 2013
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:6, s. e68007-
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Journal article (peer-reviewed)abstract
- An UPLC-MS/MS method was developed for the determination of serotonin (5-HT), dopamine (DA), their phase I metabolites 5-HIAA, DOPAC and HVA, and their sulfate and glucuronide conjugates in human brain microdialysis samples obtained from two patients with acute brain injuries, ventricular cerebrospinal fluid (CSF) samples obtained from four patients with obstructive hydrocephalus, and a lumbar CSF sample pooled mainly from patients undergoing spinal anesthesia in preparation for orthopedic surgery. The method was validated by determining the limits of detection and quantification, linearity, repeatability and specificity. The direct method enabled the analysis of the intact phase II metabolites of 5-HT and DA, without hydrolysis of the conjugates. The method also enabled the analysis of the regioisomers of the conjugates, and several intact glucuronide and sulfate conjugates were identified and quantified for the first time in the human brain microdialysis and CSF samples. We were able to show the presence of 5-HIAA sulfate, and that dopamine-3-O-sulfate predominates over dopamine-4-O-sulfate in the human brain. The quantitative results suggest that sulfonation is a more important phase II metabolism pathway than glucuronidation in the human brain.
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| 20. |
- Wang, Binmin, et al.
(author)
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Multifunctional Underwater Adhesive Film Enabled by a Single-Component Poly(ionic liquid)
- 2023
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In: ACS Nano. - : American Chemical Society (ACS). - 1936-0851 .- 1936-086X. ; 17:6, s. 5871-5879
-
Journal article (peer-reviewed)abstract
- Tremendous efforts have been devoted to exploiting synthetic wet adhesives for real-life applications. However, developing low-cost, robust, and multifunctional wet adhesive materials remains a considerable challenge. Herein, a wet adhesive composed of a single-component poly(ionic liquid) (PIL) that enables fast and robust underwater adhesion is reported. The PIL adhesive film possesses excellent stretchability and flexibility, enabling its anchoring on target substrates regardless of deformation and water scouring. Surface force measurements show the PIL can achieve a maximum adhesion of 56.7 mN·m–1 on diverse substrates (both hydrophilic and hydrophobic substrates) in aqueous media, within ∼30 s after being applied. The adhesion mechanisms of the PIL were revealed via the force measurements, and its robust wet adhesive capacity was ascribed to the synergy of different non-covalent interactions, such as of hydrogen bonding, cation−π, electrostatic, and van der Waals interactions. Surprisingly, this PIL adhesive film exhibited impressive underwater sound absorption capacity. The absorption coefficient of a 0.7 mm-thick PIL film to 4–30 kHz sound waves could be as high as 0.80–0.92. This work reports a multifunctional PIL wet adhesive that has promising applications in many areas and provides deep insights into interfacial interaction mechanisms underlying the wet adhesion capability of PILs.
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| 21. |
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| 22. |
- Zhang, Hongbo, et al.
(author)
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The formation of hydride and its influence on Ti-6Al-4V alloy fracture behavior
- 2023
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In: International journal of hydrogen energy. - : Elsevier BV. - 0360-3199 .- 1879-3487. ; 48:92, s. 36169-36184
-
Journal article (peer-reviewed)abstract
- The fracture mechanism of hydrogen charged Ti-6Al-4V has been investigated through a multianalytical approach. The difference in hydrogen solubility between 13 phase (high solubility) anda phase (low) governs the formation and growth pattern of titanium hydrides, and determine the fracture mode of Ti-6Al-4V. Depending on the hydrogen charging extent, the penetration of hydrogen and distribution of hydrides can be divided into three stages. In the initial stage hydrogen diffuses mainly into the 13 phase, as judged from its increase in Volta potential, and with no hydrides formed. Failure analysis after tensile tests exhibits plastic behavior and a fracture surface with mainly dimples. In the subsequent transition stage, hydrides are formed at the a/13 interfaces and along a grain boundaries. More initial cracks occur in the brittle hydrides and the fracture surface transforms from dimple to quasi-cleavage. In the final stage a layer of uniformly distributed hydride is produced on the surface and within the a phase. Supported by nanoindentation measurements, the plasticity of the charged sample diminishes with hydrogen charging time, and an intergranular-transgranular mixed fracture is observed. Overall, the study forms clear evidence that the distribution and cracks of hydrides influence the fracture mode of the Ti-6A-4V alloy.
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| 23. |
- Zhang, Zhong-Fa, et al.
(author)
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Detection of submicroscopic constitutional chromosome aberrations in clinical diagnostics: a validation of the practical performance of different array platforms
- 2008
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In: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1476-5438 .- 1018-4813. ; 16:7, s. 786-792
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Journal article (peer-reviewed)abstract
- For several decades etiological diagnosis of patients with idiopathic mental retardation (MR) and multiple congenital anomalies (MCA) has relied on chromosome analysis by karyotyping. Conventional karyotyping allows a genome-wide detection of chromosomal abnormalities but has a limited resolution. Recently, array-based comparative genomic hybridization (array CGH) technologies have been developed to evaluate DNA copy-number alterations across the whole-genome at a much higher resolution. It has proven to be an effective tool for detection of submicroscopic chromosome abnormalities causing congenital disorders and has recently been adopted for clinical applications. Here, we investigated four high-density array platforms with a theoretical resolution <= 100 kb: 33K tiling path BAC array, 500K Affymetrix SNP array, 385K NimbleGen oligonucleotide array and 244K Agilent oligonucleotide array for their robustness and implementation in our diagnostic setting. We evaluated the practical performance based on the detection of 10 previously characterized abnormalities whose size ranged from 100 kb to 3 Mb. Furthermore, array data analysis was performed using four computer programs developed for each corresponding platform to test their effective ability of reliable copy-number detection and their user-friendliness. All tested platforms provided sensitive performances, but our experience showed that accurate and user-friendly computer programs are of crucial importance for reliable copy-number detection.
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| 24. |
- Abbafati, Cristiana, et al.
(author)
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- 2020
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Journal article (peer-reviewed)
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