| 1. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 3. |
- Chen, Zhen, et al.
(författare)
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Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton
- 2019
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 62:7, s. 3336-3353
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Tidskriftsartikel (refereegranskat)abstract
- Monoacylglycerol lipase (MAGL) is a senile hydrolase that degrades 2-arachidonoylglycerol (2-AG) in the endocannabinoid system (eCB). Selective inhibition of MAGL has emerged as a potential therapeutic approach for the treatment of diverse pathological conditions, including chronic pain, inflammation, cancer, and neurodegeneration. Herein, we disclose a novel array of reversible and irreversible MAGL inhibitors by means of "tail switching" on a piperazinyl azetidine scaffold. We developed a lead irreversible-binding MAGL inhibitor 8 and reversible-binding compounds 17 and 37, which are amenable for radiolabeling with C-11 or F-18. [C-11]8 ([C-11]MAGL-2-11) exhibited high brain uptake and excellent binding specificity in the brain toward MAGL. Reversible radioligands [C-11]17 ([C-11]PAD) and [F-18]37 ([F-18]MAGL-4-11) also demonstrated excellent in vivo binding specificity toward MAGL in peripheral organs. This work may pave the way for the development of MAGL-targeted positron emission tomography tracers with tunability in reversible and irreversible binding mechanisms.
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| 4. |
- Yang, Ruiqi, et al.
(författare)
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Genomic insights revealed the environmental adaptability of Planococcus halotolerans Y50 isolated from petroleum-contaminated soil on the Qinghai-Tibet Plateau
- 2022
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Ingår i: Gene. - : Elsevier BV. - 0378-1119 .- 1879-0038. ; 823, s. 146368-
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Tidskriftsartikel (refereegranskat)abstract
- The Tibetan Plateau niche provides unprecedented opportunities to find microbes that are functional and commercial significance. The present study investigated the physiological and genomic characteristics of Pla-nococcus halotolerans Y50 that was isolated from a petroleum-contaminated soil sample from the Qinghai-Tibet Plateau, and it displayed psychrotolerant, antiradiation, and oil-degraded characteristics. Whole genome sequencing indicated that strain Y50 has a 3.52 Mb genome and 44.7% G + C content, and it possesses 3377 CDSs. The presence of a wide range of UV damage repair genes uvrX and uvsE, DNA repair genes radA and recN, superoxide dismutase, peroxiredoxin and dioxygenase genes provided the genomic basis for the adaptation of the plateau environment polluted by petroleum. Related experiments also verified that the Y50 strain could degrade n-alkanes from C-11-C-23, and approximately 30% of the total petroleum at 25 & DEG;C within 7 days. Meanwhile, strain Y50 could withstand 5 x 10(3) J/m(2) UVC and 10 KGy gamma ray radiation, and it had strong antioxidant and high radical scavengers for superoxide anion, hydroxyl radical and DPPH. In addition, pan-genome analysis and horizontal gene transfers revealed that strains with different niches have obtained various genes through hori -zontal gene transfer in the process of evolution, and the more similar their geographical locations, the more similar their members are genetically and ecologically. In conclusion, P. halotolerans Y50 possesses high potential of applications in the bioremediation of alpine hydrocarbons contaminated environment.
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| 5. |
- Xu, Guobao, et al.
(författare)
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Tree ring O-18's indication of a shift to a wetter climate since the 1880s in the western Tianshan Mountains of northwestern China
- 2015
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Ingår i: Journal of Geophysical Research - Atmospheres. - 2169-897X .- 2169-8996. ; 120:13, s. 6409-6425
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Tidskriftsartikel (refereegranskat)abstract
- Central Asian droughts have drastically and significantly affected agriculture and water resource management in these arid and semiarid areas. Based on tree ring O-18 from native, dominant Schrenk spruce (Picea schrenkiana Fisch. et Mey.), we developed a 300year (1710-2010) standard precipitation-evaporation index (SPEI) reconstruction from January to August for China's western Tianshan Mountains. The regression model explained 37.6% of the variation in the SPEI reconstruction during the calibration period from 1950 to 2010. Comparison with previous drought reconstructions confirmed the robustness of our reconstruction. The 20th century has been a relatively wet period during the past 300years. The SPEI showed quasi 2, 5, and 10year cycles. Several pluvials and droughts with covariability over large areas were revealed clearly in the reconstruction. The two longest pluvials (lasting for 12years), separated by 50years, appeared in the 1900s and the 1960s. The most severe drought occurred from 1739 to 1761 and from 1886 to 1911 was the wettest period since 1710. Compared to previous investigations of hydroclimatic changes in the western Tianshan Mountains, our reconstruction revealed more low-frequency variability and indicated that climate in the western Tianshan Mountains shifted from dry to wet in 1886. This regime shift was generally consistent with other moisture reconstructions for the northeastern Tibetan Plateau and northern Pakistan and may have resulted from a strengthened westerly circulation. The opposite hydrological trends in the western Tianshan Mountains and southeastern Tibetan Plateau reveal a substantial influence of strengthened westerlies and weakening of the Indian summer monsoon.
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| 6. |
- Hoshino, Ayuko, et al.
(författare)
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Tumour exosome integrins determine organotropic metastasis
- 2015
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Ingår i: Nature. - : NATURE PUBLISHING GROUP. - 0028-0836 .- 1476-4687. ; 527:7578, s. 329-
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Tidskriftsartikel (refereegranskat)abstract
- Ever since Stephen Pagets 1889 hypothesis, metastatic organotropism has remained one of cancers greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver-and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells. We show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche. Treatment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells. Exosome proteomics revealed distinct integrin expression patterns, in which the exosomal integrins alpha(6)beta(4) and alpha(6)beta(1) were associated with lung metastasis, while exosomal integrin alpha(v)beta(5) was linked to liver metastasis. Targeting the integrins alpha(6)beta(4) and alpha(v)beta(5) decreased exosome uptake, as well as lung and liver metastasis, respectively. We demonstrate that exosome integrin uptake by resident cells activates Src phosphorylation and pro-inflammatory S100 gene expression. Finally, our clinical data indicate that exosomal integrins could be used to predict organ-specific metastasis.
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| 7. |
- Nabizadeh, Armin, et al.
(författare)
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Spectral evolution of X-ray pulsar 4U 1901+03 during the 2019 outburst based on Insight-HXMT and NuSTAR observations
- 2021
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 652
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Tidskriftsartikel (refereegranskat)abstract
- We report on a detailed spectral analysis of emission from X-ray pulsar 4U 1901+03 using data obtained by the Insight-HXMT and NuSTAR observatories during the 2019 outburst of the source. Thanks to the extensive coverage of the outburst by Insight-HXMT, we were able to investigate the spectral evolution of the source as a function of flux, and compare these results to the previous reports, focusing on the properties of a putative absorption feature at around 10 keV. In particular, we demonstrate that the broadband X-ray continuum of 4U 1901+03 can be well described with a two-component continuum model without an absorption line at 10 keV, which casts doubt on its interpretation as a cyclotron line. The high quality of the data also allowed us to perform both phase-averaged and phase-resolved spectral analyses as a function of luminosity. Finally, we performed a detailed investigation of another absorption feature in the spectrum of the source around 30 keV recently reported in the NuSTAR data. We show that this feature appears to be significantly detected both in phase-averaged and phase-resolved spectra irrespective of the continuum model.
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| 8. |
- Du, Shixiong, et al.
(författare)
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Evaluating the potential benefits of float solar photovoltaics through the water footprint recovery period
- 2024
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Ingår i: Journal of Cleaner Production. - 0959-6526. ; 446
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Tidskriftsartikel (refereegranskat)abstract
- In the context of higher demands on the development of clean energy technologies due to the issue of water shortage in China and the implementation of the 2060 carbon-neutral objective, floating photovoltaic (FPV) systems present novel opportunities for transforming the energy structure through land conservation and enhancement of power generation efficiency compared to conventional solar systems. However, there is currently a lack of comprehensive analysis on the potential benefits of FPV. Utilizing reservoir databases and employing a professional FPV system design, a methodology for determining the water footprint recovery period was introduced, which enables the assessment of potential FPV benefits. The water footprint recovery period for constructing FPV on 909 reservoirs in China was found that ranges from 1.86 yr to 10.48 yr. It is found that reservoir evaporation, latitude, and climate are closely related to the water footprint recovery period of FPV. Furthermore, by implementing FPV panels with an optimal tilt angle, covering 30% of the area in each reservoir, the annual electricity generation can amount to 1429.19 TWh, leading to savings of 5.76 billion m3 of water. This achievement corresponds to 19.41% of the national electricity consumption and a 6.86% reduction in the national residential water consumption in 2020. The overall economic benefit is 5.61 myriads RMB, equivalent to 5.76% of the national GDP. These benefits are unevenly distributed and mainly concentrated in areas with more reservoirs. The anticipated enhancement of FPV system benefits is foreseen with the ongoing development and implementation of future reservoir power infrastructure and energy storage technology. These results demonstrate the significant potential of installing FPV systems on the reservoirs in China. This study proposes a method to comprehensively evaluate the comprehensive benefits of constructing FPV in China and conduct a thorough analysis of the feasibility of FPV, which could provide reference for the development of regional industries and the achievement of sustainable development goals (SDGs).
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| 9. |
- Du, Shixiong, et al.
(författare)
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Projection of Precipitation Extremes and Flood Risk in the China–Pakistan Economic Corridor
- 2022
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Ingår i: Frontiers in Environmental Science. - : Frontiers Media SA. - 2296-665X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- It is reported that the China–Pakistan Economic Corridor has been affected by extreme precipitation events. Since the 20th century, extreme weather events have occurred frequently, and the damage and loss caused by them have increased. In particular, the flood disaster caused by excessive extreme precipitation seriously hindered the development of the human society. Based on CRiteria Importance Through Intercriteria Correlation and square root of generalized cross-validation, this study used intensity–area–duration to analyze the trend of future extreme precipitation events, corrected the equidistance cumulative distribution function method deviation of different future scenario models (CESM2, CNRM-CM6-1, IPSL-CM6A-LR, and MIROC6) and evaluated the simulation ability of the revised model. The results showed that: 1) the deviation correction results of CNRM-CM6-1 in the Coupled Model Intercomparison Project Phase (CMIP) 6 could better simulate the precipitation data in the study area, and its single result could achieve the fitting effect of the CMIP5 multimodel ensemble average; 2) under CNRM-CM6-1, the frequency of extreme precipitation events under the three climate scenarios (SSP1-2.6, SSP3-7.0, and SSP5-8.5) presents interdecadal fluctuations of 3.215 times/10A, 1.215 times/10A, and 5.063 times/10A, respectively. The average impact area of extreme precipitation events would decrease in the next 30 years, while the total impact area and the extreme precipitation events in a small range would increase. Under the future scenario, the increase rate of extreme precipitation was highest in August, which increased the probability of extreme events; 3) in the next 30 years, the flood risk had an obvious expansion trend, which was mainly reflected in the expansion of the area of high-, medium-, and low-risk areas. The risk zoning results obtained by the two different flood risk assessment methods were different, but the overall risk trend was the same. This study provided more advanced research for regional flood risk, reasonable prediction for flood risk under future climate models, and useful information for flood disaster prediction in the study area and contributes to the formulation of local disaster prevention and reduction policies.
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| 10. |
- Liu, Peiji, et al.
(författare)
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A generalized method for the inherent energy performance modeling of machine tools
- 2021
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Ingår i: Journal of manufacturing systems. - : Elsevier BV. - 0278-6125 .- 1878-6642. ; 61, s. 406-422
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Tidskriftsartikel (refereegranskat)abstract
- Machine tools (MTs), as the key equipment of manufacturing systems, have enormous quantities and consume a great amount of energy. However, the diversity of both machines and their energy consumption properties make it difficult to transfer the energy-saving knowledge and services among different MT. To facilitate the initialization configuration of energy-saving services, the inherent energy performance (IEP) is investigated to describe the differences in energy consumption among MTs, and a generalized method for modeling the IEP of MT and its electrical subsystems is proposed. Three key enablers, including generalized experimental design rules, automatic coding, and data processing algorithms, are presented and integrated into a supporting system to reduce the modeling efforts and knowledge requirements. Case studies of an offline manufacturing scenario and an Internet of Things (IoT)-enabled manufacturing scenario were carried out to verify the effectiveness and convenience of the proposed method. The results show that the proposed method can provide essential modeling support for large-scale energy-saving service configurations and energy-efficient MT development.
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| 11. |
- Lu, Mengge, et al.
(författare)
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Projections of thermal growing season indices over China under global warming of 1.5 °C and 2.0 °C
- 2021
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697. ; 781
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Tidskriftsartikel (refereegranskat)abstract
- Global warming may prolong and intensify the thermal growing season of vegetation. It is not yet clear how the Paris Agreement's long-term temperature goals will affect the thermal growing season of vegetation, particularly crops, in China. Based on the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP) datasets and the Global Gridded Crop Model Intercomparison (GGCMI) phase 1 dataset, we have investigated changes in spatiotemporal patterns of four thermal growing season indices (Growing Degree Days, GDD; Length of Growing Season, GSL; the Start of Growing Season, GSS; the End of Growing Season, GSE) over China under global warming scenarios of 1.5 °C and 2.0 °C with four representative concentration pathway (RCP) scenarios. Our results indicate that during the periods which achieve the global warming of 1.5 °C and 2.0 °C, only 3.82% and 29.15% of the total areas in China have higher warming levels beyond the global warming targets. For warmer RCP scenarios (except RCP2.6), there was a rising trend for GSE, GDD and GSL and a decreasing trend for GSS in China. Many crop regions in China have also shown an advance of GSS, an extension of GSL and an earlier end of GSE under the global warming of 1.5 °C and 2.0 °C, suggesting that crop planting and harvesting dates need to be adjusted accordingly in order to capture appropriate timing for crop maturity and to achieve a maximum yield.
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| 12. |
- Schlechtweg, Dominik, et al.
(författare)
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The DURel Annotation Tool: Human and Computational Measurement of Semantic Proximity, Sense Clusters and Semantic Change
- 2024
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Ingår i: Proceedings of the 18th Conference of the European Chapter of the Association for Computational Linguistics: System Demonstrations. St. Julians, Malta. Association for Computational Linguistics, pages 137–149.
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Konferensbidrag (refereegranskat)abstract
- We present the DURel tool implementing the annotation of semantic proximity between word uses into an online, open source interface. The tool supports standardized human annotation as well as computational annotation, building on recent advances with Word-in-Context models. Annotator judgments are clustered with automatic graph clustering techniques and visualized for analysis. This allows to measure word senses with simple and intuitive micro-task judgments between use pairs, requiring minimal preparation efforts. The tool offers additional functionalities to compare the agreement between annotators to guarantee the inter-subjectivity of the obtained judgments and to calculate summary statistics over the annotated data giving insights into sense frequency distributions, semantic variation or changes of senses over time.
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| 13. |
- Sun, Huaiwei, et al.
(författare)
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Drivers of the water use efficiency changes in China during 1982–2015
- 2021
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697. ; 799
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Tidskriftsartikel (refereegranskat)abstract
- This study investigates the drivers of water use efficiency (WUE), a key metric of water resources management, and its changes over eight regions across China from 1982 to 2015 based on gross primary production (GPP) and actual evapotranspiration (AET) datasets. The order of seasonal change of WUE from large to small is autumn, summer, spring and winter. The drivers include seven variables, air temperature, specific humidity, precipitation, short-wave radiation, Normalized Difference Vegetation Index (NDVI), soil moisture and CO2. Our analysis suggests that the sensitivity of annual average NDVI to WUE changes was high nationwide, but there were some differences in seasonal scales. The annual average contribution of air temperature and CO2 affecting WUE change was relatively high in China's largest area (SW, SE, E, NP). Other influencing factors were only relatively high in the local area. Seasonally, NDVI is the driving factor with the highest contribution rate in summer and autumn for NC and NW region. The seasonal contribution rates of driving factors in other regions are significantly different. For the study period (1982–2015), the shrubland ecosystem had the highest annual WUE followed by forest and cropland. The WUE of the farmland ecosystem was higher than that of the grassland ecosystem in most areas.
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| 14. |
- Sun, Huaiwei, et al.
(författare)
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The altered drivers of evapotranspiration trends around the recent warming hiatus in China
- 2022
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Ingår i: International Journal of Climatology. - : Wiley. - 0899-8418 .- 1097-0088. ; 42:16, s. 8405-8422
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Tidskriftsartikel (refereegranskat)abstract
- This study focuses on the trends and the causes of variation in actual evapotranspiration (AET) around the warming hiatus over China by a comprehensive analysis applying various temporal–spatial methods. It is observed that the annual AET showed a different trend around 2000 for China as a whole. By employing segmented regression analysis for detecting warming hiatus points, high temporal inconsistency can be found in eight climatic regions of China. The impacts of meteorological variables on AET were further identified by affecting the intensity and relative change of meteorological factors. AET was highly correlated (p <.01) with solar radiation in the southeast (R = 0.80) and air specific humidity in the northwest areas (R = 0.83). AET changes presented the highest sensitivity to specific humidity in Northwest before 2006 and in north central China after 2003, with sensitivity coefficients of 1.48 and 1.74, respectively. Three variables, including air specific humidity (with an average contribution rate of ~17% in the northwest), short-wave radiation and air temperature, can be the main factors that lead to the changes in AET. The specific meteorological factors varied from region to region: the changes in AET can be ascribed to the increased wind and short-wave radiation in north central China and east China, the decreased air temperature in Tibetan Plateau, the increased specific humidity in southeast China during warming hiatus, and so on. After the warming hiatus occurred, the dominant factor of AET trends changed from air specific humidity to short-wave radiation and other factors. Generally, air specific humidity and air temperature have played leading roles in AET trends during the past 30 years.
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| 15. |
- Wang, Kai-Tuo, et al.
(författare)
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Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA
- 2012
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 1362-4962 .- 0305-1048. ; 40:11, s. 48-5138
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Tidskriftsartikel (refereegranskat)abstract
- The 23S rRNA nucleotide m(2)G2445 is highly conserved in bacteria, and in Escherichia coli this modification is added by the enzyme YcbY. With lengths of around 700 amino acids, YcbY orthologs are the largest rRNA methyltransferases identified in Gram-negative bacteria, and they appear to be fusions from two separate proteins found in Gram-positives. The crystal structures described here show that both the N- and C-terminal halves of E. coli YcbY have a methyltransferase active site and their folding patterns respectively resemble the Streptococcus mutans proteins Smu472 and Smu776. Mass spectrometric analyses of 23S rRNAs showed that the N-terminal region of YcbY and Smu472 are functionally equivalent and add the m(2)G2445 modification, while the C-terminal region of YcbY is responsible for the m(7)G2069 methylation on the opposite side of the same helix (H74). Smu776 does not target G2069, and this nucleotide remains unmodified in Gram-positive rRNAs. The E.coli YcbY enzyme is the first example of a methyltransferase catalyzing two mechanistically different types of RNA modification, and has been renamed as the Ribosomal large subunit methyltransferase, RlmKL. Our structural and functional data provide insights into how this bifunctional enzyme evolved.
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| 16. |
- Yan, Dong, et al.
(författare)
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Allocation of ecological water rights considering ecological networks in arid watersheds : A framework and case study of Tarim River basin
- 2022
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Ingår i: Agricultural Water Management. - : Elsevier BV. - 0378-3774. ; 267
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Tidskriftsartikel (refereegranskat)abstract
- A robust water supply system is significant to the local ecosystem of riparian vegetation in the arid basin. Considering the elasticity and relative importance of ecological water use in different regions of the basin, this study defines the ecological water rights on a multi-year scale, divides the priority of those rights based on the ecological network, and proposes a rights allocation method. The application of the method to the mainstream watershed of Tarim River in China shows that when the overall available ecological water is only 77% of the ecological water demand, it can ensure that the ecological water demand of vegetation in important areas is fully met and the growth condition is good. However, the demand in non-important areas must be less than 50% and the growth condition will deteriorate. This method expands the existing definition and distribution of water rights, and the approach of coupling ecological networks can be used for the efficient management of ecological water supply in other arid basins.
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| 17. |
- Zhao, Bingqian, et al.
(författare)
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Quantifying changes and drivers of runoff in the Kaidu River Basin associated with plausible climate scenarios
- 2021
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Ingår i: Journal of Hydrology: Regional Studies. - : Elsevier BV. - 2214-5818. ; 38
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Tidskriftsartikel (refereegranskat)abstract
- Study region: The Kaidu River Basin (KRB) is located on the central southern slope of the Tianshan Mountain in Northwest China. Study focus: This work aimed to assess changes and main drivers of snowmelt-driven runoff in KRB associated with three future climate scenarios. Six versions of the “Cemaneige” snowmelt module embedded in the hydrological model “GR4J” were calibrated and evaluated. The bias-corrected climate datasets from CMIP5 Models were used to drive the optimal snowmelt-hydrological model for runoff prediction. The factors that lead to runoff variations were also assessed. New hydrological insights: The significant declining trends of runoff were only predicted in the RCP4.5 and RCP8.5 scenarios. The declining trends of runoff were found in all the seasons. For the annual and summer runoff, compared to the historical period, both the RCP2.6 and RCP 4.5 periods showed a decline in the mid-century and a rise in the end-century; however, RCP8.5 showed a continuous decline during this period. Precipitation and evapotranspiration were ranked as the two most important factors regulating future runoff variations in all RCPs. In contrast, snowmelt timing is the second factor in the historical period, and its importance decreases in the warmer RCP scenarios. These results highlighted that the importance of snowmelt and snowmelt timing to the future runoff depends on the runoff responses to the trajectory of future changes in temperature and precipitation.
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