| 1. |
- Ekselius, Lisa, et al.
(författare)
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Effect of Personality Disorders on Treatment Outcome of Surgery for Low Back Pain
- 1996
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Ingår i: Journal of Musculoskeletal Pain. - 1058-2452 .- 1540-7012. ; 4:3, s. 87-96
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Tidskriftsartikel (refereegranskat)abstract
- Objective To determine if the presence of a personality disorder would effect the long-term outcome of surgery for low back pain. Methods: Personality disorders were assessed by means of the Structured Clinical Interview for Diagnosis Statistical Manual-II Revised [SCID] Screen questionnaire. Outcome was assessed from reported experience of pain, global change and working status at follow up. Results: The frequency of personality disorders was 16%. Patients with a "Dramatic" personality disorder had more pain at follow up. Conclusions: The results indicate that the presence of a personality disorder might result in a worse long-term outcome after surgery for low back pain.
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| 2. |
- Graven-Nielsen, T., et al.
(författare)
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Central hyperexcitability in fibromyalgia
- 1999
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Ingår i: Journal of Musculoskeletal Pain. - 1058-2452 .- 1540-7012. ; 7, s. 261-267
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Henriksson, Karl-Gösta, 1928-
(författare)
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Muscle activity and chronic muscle pain.
- 1999
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Ingår i: Journal of Musculoskeletal Pain. - 1058-2452 .- 1540-7012. ; 7, s. 101-109
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Tidskriftsartikel (refereegranskat)
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| 4. |
- Sandberg, Margareta, et al.
(författare)
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Manual Acupuncture in Fibromyalgia : A Long-Term Pilot Study
- 1999
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Ingår i: Journal of Musculoskeletal Pain. - 1058-2452. ; 7:3, s. 39-58
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The aim of this cross-over designed pilot study was to investigate the short-term and long-term effects on pain and other common symptoms present in fibromyalgia [FMS] of manual acupuncture with needles inserted into traditional Chinese acupuncture points. Methods: Nine out of 10 consecutive FMS patients completed the study. Acupuncture was given in 10-14 sessions over two to three months, followed by an observation period of six months. The control regime consisted of continuous medical management. The patients were evaluated immediately after the completion of the treatment and at 4, 8, 12, and 24 weeks. Pain, sleep, medication, muscle tension, psychological tension, general well-being, the number of tender points, and range of movement in shoulders and neck were assessed. Results: In general, significantly greater changes occurred for the variables under investigation during the acupuncture period than during the control period. Nine of the 11 outcome variables showed a significant improvement after acupuncture period. The number of tender points was significantly decreased and the sense of well-being significantly improved up to 12 week follow-up. A significant decrease in general pain persisted for eight weeks. Muscle tension and local pain in head, neck, and shoulder regions were significantly reduced throughout the whole 24 week follow-up period. According to the patients' evaluation of global treatment outcome, improvements remained significant until the four week follow-up. Base-line values of well-being and sleep patterns were the most important predictors of treatment outcome. Conclusion: We conclude that for some FMS patients 10-14 acupuncture sessions seem to give additional benefits over a limited period.
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| 5. |
- Ben Amara, Heithem, 1984, et al.
(författare)
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Magnesium implant degradation provides immunomodulatory and proangiogenic effects and attenuates peri-implant fibrosis in soft tissues
- 2023
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Ingår i: Bioactive Materials. - : Elsevier BV. - 2452-199X. ; 26, s. 353-369
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Tidskriftsartikel (refereegranskat)abstract
- Implants made of magnesium (Mg) are increasingly employed in patients to achieve osteosynthesis while degrading in situ. Since Mg implants and Mg2+ have been suggested to possess anti-inflammatory properties, the clinically observed soft tissue inflammation around Mg implants is enigmatic. Here, using a rat soft tissue model and a 1-28 d observation period, we determined the temporo-spatial cell distribution and behavior in relation to sequential changes of pure Mg implant surface properties and Mg2+ release. Compared to nondegradable titanium (Ti) implants, Mg degradation exacerbated initial inflammation. Release of Mg degradation products at the tissue-implant interface, culminating at 3 d, actively initiated chemotaxis and upregulated mRNA and protein immunomodulatory markers, particularly inducible nitric oxide synthase and toll-like receptor-4 up to 6 d, yet without a cytotoxic effect. Increased vascularization was demonstrated morphologically, preceded by high expression of vascular endothelial growth factor. The transition to appropriate tissue repair coincided with implant surface enrichment of Ca and P and reduced peri-implant Mg2+ concentration. Mg implants revealed a thinner fibrous encapsulation compared with Ti. The detailed understanding of the relationship between Mg material properties and the spatial and time-resolved cellular processes provides a basis for the interpretation of clinical observations and future tailoring of Mg implants.
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| 6. |
- Bruns, S., et al.
(författare)
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On the material dependency of peri-implant morphology and stability in healing bone
- 2023
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Ingår i: Bioactive Materials. - : Elsevier. - 2452-199X. ; 28, s. 155-166
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Tidskriftsartikel (refereegranskat)abstract
- The microstructural architecture of remodeled bone in the peri-implant region of screw implants plays a vital role in the distribution of strain energy and implant stability. We present a study in which screw implants made from titanium, polyetheretherketone and biodegradable magnesium-gadolinium alloys were implanted into rat tibia and subjected to a push-out test four, eight and twelve weeks after implantation. Screws were 4 mm in length and with an M2 thread. The loading experiment was accompanied by simultaneous three-dimensional imaging using synchrotron-radiation microcomputed tomography at 5 mu m resolution. Bone deformation and strains were tracked by applying optical flow-based digital volume correlation to the recorded image sequences. Implant stabilities measured for screws of biodegradable alloys were comparable to pins whereas non-degradable biomaterials experienced additional mechanical stabilization. Peri-implant bone morphology and strain transfer from the loaded implant site depended heavily on the biomaterial utilized. Titanium implants stimulated rapid callus formation displaying a consistent monomodal strain profile whereas the bone volume fraction in the vicinity of magnesium-gadolinium alloys exhibited a minimum close to the interface of the implant and less ordered strain transfer. Correlations in our data suggest that implant stability benefits from disparate bone morphological properties depending on the biomaterial utilized. This leaves the choice of biomaterial as situational depending on local tissue properties.
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| 7. |
- Chen, Song, et al.
(författare)
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Early osteoimmunomodulation by mucin hydrogels augments the healing and revascularization of rat critical-size calvarial bone defects
- 2023
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Ingår i: BIOACTIVE MATERIALS. - : Elsevier BV. - 2452-199X. ; 25, s. 176-188
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Tidskriftsartikel (refereegranskat)abstract
- The design principle of osteogenic bone grafts has shifted from immunological inertness to limiting foreign body response to combined osteoimmunomodulatory activity to promote high-quality endogenous bone regeneration. Recently developed immunomodulatory mucin hydrogels have been shown to elicit very low complement activation and suppress macrophage release and activation after implantation in vivo. However, their immunoregulatory activity has not yet been studied in the context of tissue repair. Herein, we synthesized mucinmonetite composite materials and investigated their early osteoimmunomodulation using a critical-size rat bone defect model. We demonstrated that the composites can polarize macrophages towards the M2 phenotype at weeks 1 and 2. The early osteoimmunomodulation enhanced early osteogenesis and angiogenesis and ultimately promoted fracture healing and engraftment (revascularization of the host vasculature) at weeks 6 and 12. Overall, we demonstrated the applicability of mucin-based immunomodulatory biomaterials to enhance tissue repair in tissue engineering and regenerative medicine.
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| 8. |
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| 9. |
- Kruger, D., et al.
(författare)
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High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D
- 2022
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Ingår i: Bioactive Materials. - : Elsevier BV. - 2452-199X. ; 13, s. 37-52
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Tidskriftsartikel (refereegranskat)abstract
- Biodegradable magnesium (Mg) alloys can revolutionize osteosynthesis, because they have mechanical properties similar to those of the bone, and degrade over time, avoiding the need of removal surgery. However, they are not yet routinely applied because their degradation behavior is not fully understood. In this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium (Gd) at high resolution. Mg-5Gd and Mg-10Gd screws were inserted in rat tibia for 4, 8 and 12 weeks. Afterward, the degradation rate and degradation homogeneity, as well as bone-to-implant interface, were studied with synchrotron radiation micro computed tomography and histology. Titanium (Ti) and polyether ether ketone (PEEK) were used as controls material to evaluate osseointegration. Our results showed that Mg-5Gd degraded faster and less homogeneously than Mg-10Gd. Both alloys gradually form a stable degradation layer at the interface and were surrounded by new bone tissue. The results were correlated to in vitro data obtained from the same material and shape. The average bone-to-implant contact of the Mg-xGd implants was comparable to that of Ti and higher than for PEEK. The results suggest that both Mg-xGd alloys are suitable as materials for bone implants.
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| 10. |
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| 11. |
- Shah, Furqan A., et al.
(författare)
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Bone without borders - Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope
- 2023
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Ingår i: Bioactive Materials. - : Elsevier BV. - 2452-199X. ; 19, s. 103-114
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Tidskriftsartikel (refereegranskat)abstract
- Calcium phosphates (CaP) represent an important class of osteoconductive and osteoinductive biomaterials. As proof-of-concept, we show how a multi-component CaP formulation (monetite, beta-tricalcium phosphate, and calcium pyrophosphate) guides osteogenesis beyond the physiological envelope. In a sheep model, hollow dome-shaped constructs were placed directly over the occipital bone. At 12 months, large amounts of bone (similar to 75%) occupy the hollow space with strong evidence of ongoing remodelling. Features of both compact bone (osteonal/osteon-like arrangements) and spongy bone (trabeculae separated by marrow cavities) reveal insights into function/need-driven microstructural adaptation. Pores within the CaP also contain both woven bone and vascularised lamellar bone. Osteoclasts actively contribute to CaP degradation/removal. Of the constituent phases, only calcium pyrophosphate persists within osseous (cutting cones) and non-osseous (macrophages) sites. From a translational perspective, this multi-component CaP opens up exciting new avenues for osteotomy-free and minimally-invasive repair of large bone defects and augmentation of the dental alveolar ridge.
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| 12. |
- Sharifi, Sina, et al.
(författare)
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Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications
- 2021
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Ingår i: Bioactive Materials. - : Elsevier. - 2452-199X. ; 6:11, s. 3947-3961
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Tidskriftsartikel (refereegranskat)abstract
- Gelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility, easy processability, transparency, non-toxicity, and reasonable mechanical properties to mimic the extracellular matrix (ECM). Gelatin adhesives can be easily tuned to gain different viscoelastic and mechanical properties that facilitate its ocular application. We herein grafted glycidyl methacrylate on the gelatin backbone with a simple chemical modification of the precursor, utilizing epoxide ring-opening reactions and visible light-crosslinking. This chemical modification allows the obtaining of an elastic protein-based hydrogel (GELGYM) with excellent biomimetic properties, approaching those of the native tissue. GELGYM can be modulated to be stretched up to 4 times its initial length and withstand high tensile stresses up to 1.95 MPa with compressive strains as high as 80% compared to Gelatin-methacryloyl (GeIMA), the most studied derivative of gelatin used as a bioadhesive. GELGYM is also highly biocompatible and supports cellular adhesion, proliferation, and migration in both 2 and 3-dimensional cell-cultures. These characteristics along with its super adhesion to biological tissues such as cornea, aorta, heart, muscle, kidney, liver, and spleen suggest widespread applications of this hydrogel in many biomedical areas such as transplantation, tissue adhesive, wound dressing, bioprinting, and drug and cell delivery.
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| 13. |
- Tian, Xinggui, et al.
(författare)
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Co-delivery of rhBMP-2 and zoledronic acid using calcium sulfate/hydroxyapatite carrier as a bioactive bone substitute to enhance and accelerate spinal fusion
- 2024
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Ingår i: Bioactive Materials. - 2452-199X. ; 36, s. 256-271
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Tidskriftsartikel (refereegranskat)abstract
- Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been FDA-approved for lumbar fusion, but supraphysiologic initial burst release due to suboptimal carrier and late excess bone resorption caused by osteoclast activation have limited its clinical usage. One strategy to mitigate the pro-osteoclast side effect of rhBMP-2 is to give systemic bisphosphonates, but it presents challenges with systemic side effects and low local bioavailability. The aim of this in vivo study was to analyze if posterolateral spinal fusion (PLF) could be improved by utilizing a calcium sulfate/hydroxyapatite (CaS/HA) carrier co-delivering rhBMP-2 and zoledronic acid (ZA). Six groups were allocated (CaS/HA, CaS/HA + BMP-2, CaS/HA + systemic ZA, CaS/HA + local ZA, CaS/HA + BMP-2 + systemic ZA, and CaS/HA + BMP-2 + local ZA). 10-week-old male Wistar rats, were randomly assigned to undergo L4-L5 PLF with implantation of group-dependent scaffolds. At 3 and 6 weeks, the animals were euthanized for radiography, μCT, histological staining, or biomechanical testing to evaluate spinal fusion. The results demonstrated that the CaS/HA biomaterial alone or in combination with local or systemic ZA didn't support PLF. However, the delivery of rhBMP-2 significantly promoted PLF. Combining systemic ZA with BMP-2 didn't enhance spinal fusion. Notably, the co-delivery of rhBMP-2 and ZA using the CaS/HA carrier significantly enhanced and accelerated PLF, without inhibiting systemic bone turnover, and potentially reduced the dose of rhBMP-2. Together, the treatment regimen of CaS/HA biomaterial co-delivering rhBMP-2 and ZA could potentially be a safe and cost-effective off-the-shelf bioactive bone substitute to enhance spinal fusion.
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| 14. |
- Tommasini, Giuseppina, et al.
(författare)
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Seamless integration of bioelectronic interface in an animal model via in vivo polymerization of conjugated oligomers
- 2022
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Ingår i: Bioactive Materials. - : Elsevier BV. - 2452-199X. ; 10, s. 107-116
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Tidskriftsartikel (refereegranskat)abstract
- Leveraging the biocatalytic machinery of living organisms for fabricating functional bioelectronic interfaces, in vivo, defines a new class of micro-biohybrids enabling the seamless integration of technology with living biological systems. Previously, we have demonstrated the in vivo polymerization of conjugated oligomers forming conductors within the structures of plants. Here, we expand this concept by reporting that Hydra, an invertebrate animal, polymerizes the conjugated oligomer ETE-S both within cells that expresses peroxidase activity and within the adhesive material that is secreted to promote underwater surface adhesion. The resulting conjugated polymer forms electronically conducting and electrochemically active μm-sized domains, which are inter-connected resulting in percolative conduction pathways extending beyond 100 μm, that are fully integrated within the Hydra tissue and the secreted mucus. Furthermore, the introduction and in vivo polymerization of ETE-S can be used as a biochemical marker to follow the dynamics of Hydra budding (reproduction) and regeneration. This work paves the way for well-defined self-organized electronics in animal tissue to modulate biological functions and in vivo biofabrication of hybrid functional materials and devices.
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