1. |
- Murari, A., et al.
(författare)
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A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors
- 2024
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Ingår i: Nature Communications. - 2041-1723 .- 2041-1723. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- The objective of thermonuclear fusion consists of producing electricity from the coalescence of light nuclei in high temperature plasmas. The most promising route to fusion envisages the confinement of such plasmas with magnetic fields, whose most studied configuration is the tokamak. Disruptions are catastrophic collapses affecting all tokamak devices and one of the main potential showstoppers on the route to a commercial reactor. In this work we report how, deploying innovative analysis methods on thousands of JET experiments covering the isotopic compositions from hydrogen to full tritium and including the major D-T campaign, the nature of the various forms of collapse is investigated in all phases of the discharges. An original approach to proximity detection has been developed, which allows determining both the probability of and the time interval remaining before an incoming disruption, with adaptive, from scratch, real time compatible techniques. The results indicate that physics based prediction and control tools can be developed, to deploy realistic strategies of disruption avoidance and prevention, meeting the requirements of the next generation of devices.
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5. |
- Krasilnikov, A., et al.
(författare)
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Evidence of 9 Be + p nuclear reactions during 2ω CH and hydrogen minority ICRH in JET-ILW hydrogen and deuterium plasmas
- 2018
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:2
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Tidskriftsartikel (refereegranskat)abstract
- The intensity of 9Be + p nuclear fusion reactions was experimentally studied during second harmonic (2ω CH) ion-cyclotron resonance heating (ICRH) and further analyzed during fundamental hydrogen minority ICRH of JET-ILW hydrogen and deuterium plasmas. In relatively low-density plasmas with a high ICRH power, a population of fast H+ ions was created and measured by neutral particle analyzers. Primary and secondary nuclear reaction products, due to 9Be + p interaction, were observed with fast ion loss detectors, γ-ray spectrometers and neutron flux monitors and spectrometers. The possibility of using 9Be(p, d)2α and 9Be(p, α)6Li nuclear reactions to create a population of fast alpha particles and study their behaviour in non-active stage of ITER operation is discussed in the paper.
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9. |
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10. |
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Overview of the JET results
- 2015
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 55:10
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Tidskriftsartikel (refereegranskat)
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11. |
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- 2018
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:1
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Forskningsöversikt (refereegranskat)
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12. |
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13. |
- Bombarda, F., et al.
(författare)
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Runaway electron beam control
- 2019
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 1361-6587 .- 0741-3335. ; 61:1
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Tidskriftsartikel (refereegranskat)
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14. |
- Joffrin, E., et al.
(författare)
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Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
- 2019
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Forskningsöversikt (refereegranskat)abstract
- For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
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29. |
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31. |
- Romanelli, F, et al.
(författare)
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Overview of the JET results
- 2011
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 51:9
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Tidskriftsartikel (refereegranskat)abstract
- Since the last IAEA Conference JET has been in operation for one year with a programmatic focus on the qualification of ITER operating scenarios, the consolidation of ITER design choices and preparation for plasma operation with the ITER-like wall presently being installed in JET. Good progress has been achieved, including stationary ELMy H-mode operation at 4.5 MA. The high confinement hybrid scenario has been extended to high triangularity, lower ρ*and to pulse lengths comparable to the resistive time. The steady-state scenario has also been extended to lower ρ*and ν*and optimized to simultaneously achieve, under stationary conditions, ITER-like values of all other relevant normalized parameters. A dedicated helium campaign has allowed key aspects of plasma control and H-mode operation for the ITER non-activated phase to be evaluated. Effective sawtooth control by fast ions has been demonstrated with3He minority ICRH, a scenario with negligible minority current drive. Edge localized mode (ELM) control studies using external n = 1 and n = 2 perturbation fields have found a resonance effect in ELM frequency for specific q95values. Complete ELM suppression has, however, not been observed, even with an edge Chirikov parameter larger than 1. Pellet ELM pacing has been demonstrated and the minimum pellet size needed to trigger an ELM has been estimated. For both natural and mitigated ELMs a broadening of the divertor ELM-wetted area with increasing ELM size has been found. In disruption studies with massive gas injection up to 50% of the thermal energy could be radiated before, and 20% during, the thermal quench. Halo currents could be reduced by 60% and, using argon/deuterium and neon/deuterium gas mixtures, runaway electron generation could be avoided. Most objectives of the ITER-like ICRH antenna have been demonstrated; matching with closely packed straps, ELM resilience, scattering matrix arc detection and operation at high power density (6.2 MW m-2) and antenna strap voltages (42 kV). Coupling measurements are in very good agreement with TOPICA modelling. © 2011 IAEA, Vienna.
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32. |
- Abel, I, et al.
(författare)
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Overview of the JET results with the ITER-like wall
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 53:10, s. 104002-
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Tidskriftsartikel (refereegranskat)abstract
- Following the completion in May 2011 of the shutdown for the installation of the beryllium wall and the tungsten divertor, the first set of JET campaigns have addressed the investigation of the retention properties and the development of operational scenarios with the new plasma-facing materials. The large reduction in the carbon content (more than a factor ten) led to a much lower Z(eff) (1.2-1.4) during L- and H-mode plasmas, and radiation during the burn-through phase of the plasma initiation with the consequence that breakdown failures are almost absent. Gas balance experiments have shown that the fuel retention rate with the new wall is substantially reduced with respect to the C wall. The re-establishment of the baseline H-mode and hybrid scenarios compatible with the new wall has required an optimization of the control of metallic impurity sources and heat loads. Stable type-I ELMy H-mode regimes with H-98,H-y2 close to 1 and beta(N) similar to 1.6 have been achieved using gas injection. ELM frequency is a key factor for the control of the metallic impurity accumulation. Pedestal temperatures tend to be lower with the new wall, leading to reduced confinement, but nitrogen seeding restores high pedestal temperatures and confinement. Compared with the carbon wall, major disruptions with the new wall show a lower radiated power and a slower current quench. The higher heat loads on Be wall plasma-facing components due to lower radiation made the routine use of massive gas injection for disruption mitigation essential.
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33. |
- Frassinetti, Lorenzo, et al.
(författare)
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Dimensionless scalings of confinement, heat transport and pedestal stability in JET-ILW and comparison with JET-C
- 2017
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 59:1
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Tidskriftsartikel (refereegranskat)abstract
- Three dimensionless scans in the normalized Larmor radius rho*, normalized collisionality nu* and normalized plasma pressure beta have been performed in JET with the ITER-like wall (JET-ILW). The normalized energy confinement and the thermal diffusivity exhibit a scaling with rho* consistent with the earlier results obtained in the carbon wall JET (JET-C) and with a gyro-Bohm scaling. In the pedestal, experimental results show that the stability is not dependent on rho*, qualitatively in agreement with the peeling-ballooning (P-B) model. The nu* dimensionless scaling shows that JET-ILW normalized confinement has a stronger dependence on collisionality than JET-C. This leads to a reduction of the difference in the confinement between JET-ILW and JET-C to approximate to 10% at low nu*. The pedestal stability shows an improvement with decreasing nu*. This is ascribed to the increase of the bootstrap current, to the reduction of the pedestal width and to the reduction of the relative shift between pedestal density and temperature position. The beta dimensionless scan shows that, at low collisionality, JET-ILW normalized confinement has no clear dependence with beta, in agreement with part of the earlier scalings. At high collisionality, a reduction of the normalized confinement with increasing beta is observed. This behaviour is driven mainly by the pedestal where the stability is reduced with increasing beta. The P-B analysis shows that the stability reduction with increasing beta at high nu* is due to the destabilizing effect of the increased relative shift.
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34. |
- Lennholm, M., et al.
(författare)
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Real-time control of ELM and sawtooth frequencies : Similarities and differences
- 2015
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Ingår i: Nuclear Fusion. - : Institute of Physics Publishing (IOPP). - 0029-5515 .- 1741-4326. ; 56:1
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Tidskriftsartikel (refereegranskat)abstract
- ELMs and Sawteeth, located in different parts of the plasma, are similar from a control engineering point of view. Both manifest themselves through quiescent periods interrupted by periodic collapses. For both, large collapses, following long quiescent periods, have detrimental effects while short periods are associated with decreased confinement. Following the installation of the all metal ’ITER like wall’ on JET, sawteeth and ELMs also play an important role by expelling tungsten from the core and edge of the plasma respectively. Control of tungsten has therefore been added to divertor heat load reduction, NTM avoidance and helium ash removal as reasons for requiring ELM and sawtooth control. It is therefore of interest to implement control systems to maintain the sawtooth and ELM frequencies in the desired ranges. On JET, ELM frequency control uses radial field ’kicks’ and pellet and gas injection as actuators, while sawtooth control uses ion cyclotron resonance heating (ICRH). JET experiments have, for the first time, established feedback control of the ELM frequency, via real time variation of the injected gas flow [1]. Using this controller in conjunction with pellet injection allows the ELM frequency to be kept as required despite variations in pellet ELM triggering efficiency. JET Sawtooth control experiments have, for the first time, demonstrated that low field side ICRH, as foreseen for ITER, can shorten sawteeth lengthened by central fast ions [2]. The development of ELM and sawtooth control could be key to achieve stable high performance JET discharges with minimal tungsten content. Integrating such schemes into an overall control strategy will be required in future tokamaks and gaining experience on current tokamaks is essential.
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35. |
- Asp, F, et al.
(författare)
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Development of Sound Localization in Infants and Young Children with Cochlear Implants
- 2022
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Ingår i: Journal of clinical medicine. - : MDPI AG. - 2077-0383. ; 11:22
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Tidskriftsartikel (refereegranskat)abstract
- Cochlear implantation as a treatment for severe-to-profound hearing loss allows children to develop hearing, speech, and language in many cases. However, cochlear implants are generally provided beyond the infant period and outcomes are assessed after years of implant use, making comparison with normal development difficult. The aim was to study whether the rate of improvement of horizontal localization accuracy in children with bilateral implants is similar to children with normal hearing. A convenience sample of 20 children with a median age at simultaneous bilateral implantation = 0.58 years (0.42–2.3 years) participated in this cohort study. Longitudinal follow-up of sound localization accuracy for an average of ≈1 year generated 42 observations at a mean age = 1.5 years (0.58–3.6 years). The rate of development was compared to historical control groups including children with normal hearing and with relatively late bilateral implantation (≈4 years of age). There was a significant main effect of time with bilateral implants on localization accuracy (slope = 0.21/year, R2 = 0.25, F = 13.6, p < 0.001, n = 42). No differences between slopes (F = 0.30, p = 0.58) or correlation coefficients (Cohen’s q = 0.28, p = 0.45) existed when comparing children with implants and normal hearing (slope = 0.16/year since birth, p = 0.015, n = 12). The rate of development was identical to children implanted late. Results suggest that early bilateral implantation in children with severe-to-profound hearing loss allows development of sound localization at a similar age to children with normal hearing. Similar rates in children with early and late implantation and normal hearing suggest an intrinsic mechanism for the development of horizontal sound localization abilities.
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36. |
- Catarino, N., et al.
(författare)
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Assessment of erosion, deposition and fuel retention in the JET-ILW divertor from ion beam analysis data
- 2017
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Ingår i: Nuclear Materials and Energy. - : ELSEVIER. - 2352-1791. ; 12, s. 559-563
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Tidskriftsartikel (refereegranskat)abstract
- Post-mortem analyses of individual components provide relevant information on plasma-surface interactions like tungsten erosion, beryllium deposition and plasma fuel retention with divertor tiles via implantation or co-deposition. Ion Beam techniques are ideal tools for such purposes and have been extensively used for post-mortem analyses of selected tiles from JET following each campaign. In this contribution results from tiles removed from the JET ITER-Like Wall (JET-ILW) divertor following the 2013-2014 campaign are presented. The results summarize erosion, deposition and fuel retention along the poloidal cross section of the divertor surface and provide data for comparison with the first JET-ILW campaign, showing a similar pattern of material migration with the exception of Tile 6 where the strike point time on the tile was similar to 4 times longer in 2013-2014 than in 2011-2012, which is likely to account for more material migration to this region. The W deposition on top of the Mo marker coating of Tile 4 shows that the enrichment takes place at the strike point location. (C) 2016 The Authors. Published by Elsevier Ltd.
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37. |
- de la Luna, E., et al.
(författare)
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Understanding the physics of ELM pacing via vertical kicks in JET in view of ITER
- 2016
-
Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 56:2
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Tidskriftsartikel (refereegranskat)abstract
- Experiments on JET, with both the previous carbon wall (JET-C) and the new Be/W wall (JET-ILW), have demonstrated the efficacy of using a fast vertical plasma motion (known as vertical kicks in JET) for active ELM control. In this paper we report on a series of experiments that have been recently conducted in JET-ILW with the goal of further improving the physics understanding of the processes governing the triggering of ELMs via vertical kicks. This is a necessary step to confidently extrapolate this ELM control method to ITER. Experiments have shown that ELMs can be reliably triggered provided a minimum vertical plasma displacement and velocity is imposed. The magnitude of the minimum displacement depends on the plasma parameters, being smaller for higher pedestal temperatures and lower collisionalities, which is encouraging in view of ITER. Modelling and stability analysis suggest that a localized current density induced by the vertical plasma movement close to the separatrix plays a major role in the ELM triggering mechanism, which is consistent with the experimental observations. The implications of these results for the extrapolation of this ELM control scheme to ITER are discussed.
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38. |
- Delabie, E., et al.
(författare)
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In situ wavelength calibration of the edge CXS spectrometers on JET
- 2016
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Ingår i: Review of Scientific Instruments. - : AMER INST PHYSICS. - 0034-6748 .- 1089-7623. ; 87:11
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Tidskriftsartikel (refereegranskat)abstract
- A method for obtaining an accurate wavelength calibration over the entire focal plane of the JET edge CXS spectrometers is presented that uses a combination of the fringe pattern created with a Fabry-Perot etalon and a neon lamp for cross calibration. The accuracy achieved is 0.03 angstrom, which is the same range of uncertainty as when neglecting population effects on the rest wavelength of the CX line. For the edge CXS diagnostic, this corresponds to a flow velocity of 4.5 km/s in the toroidal direction or 1.9 km/s in the poloidal direction.
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39. |
- Edgren, Fredrik, et al.
(författare)
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Compressive failure of impacted NCF composite sandwich panels - Characterisation of the failure process
- 2004
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Ingår i: Journal of composite materials. - : SAGE Publications. - 0021-9983 .- 1530-793X. ; 38:6, s. 495-514
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Tidskriftsartikel (refereegranskat)abstract
- In the present study, non-crimp fabric (NCF) composite face sheet sandwich panels have been tested in compression after impact (CAI). Damage in the face sheets was characterised by fractography. Compression after impact loaded panels were found to fail by plastic fibre microbuckling (kinking) in the damaged face sheet. Studies of panels for which loading was interrupted prior to failure revealed extensive stable kink band formation at several positions and in numerous plies. Kink bands initiated and propagated within a wide region close to the point of impact. In addition, kink bands initiated in zones with high shear stresses, away from the impact centre line. Consequently, the fractographic results from this investigation do not support the assumption of modelling the impact damage as an equivalent hole. To achieve accurate predictions of kink band initiation, the stress field must be known. The results from this study imply that bending effects caused by remaining dent or material eccentricities in the damaged region must be considered.
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40. |
- Fortuna-Zalesna, E., et al.
(författare)
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Studies of dust from JET with the ITER-Like Wall : Composition and internal structure
- 2017
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Ingår i: Nuclear Materials and Energy. - : ELSEVIER. - 2352-1791. ; 12, s. 582-587
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Tidskriftsartikel (refereegranskat)abstract
- Results are presented for the dust survey performed at JET after the second experimental campaign with the ITER-Like Wall: 2013-2014. Samples were collected on adhesive stickers from several different positions in the divertor both on the tiles and on the divertor carrier. Brittle dust-forming deposits on test mirrors from the inner divertor wall were also studied. Comprehensive characterization accomplished by a wide range of high-resolution microscopy techniques, including focused ion beam, has led to the identification of several classes of particles: (i) beryllium flakes originating either from the Be coatings from the inner wall cladding or Be-rich mixed co-deposits resulting from material migration; (ii) beryllium droplets and splashes; (iii) tungsten and nickel-rich (from Inconel) droplets; (iv) mixed material layers with a various content of small (8-200 nm) W-Mo and Ni-based debris. A significant content of nitrogen from plasma edge cooling has been identified in all types of co-deposits. A comparison between particles collected after the first and second experimental campaign is also presented and discussed. (C) 2016 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
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41. |
- Frassinetti, Lorenzo, et al.
(författare)
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Global and pedestal confinement and pedestal structure in dimensionless collisionality scans of low-triangularity H-mode plasmas in JET-ILW
- 2017
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 57:1
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Tidskriftsartikel (refereegranskat)abstract
- A dimensionless collisionality scan in low-triangularity plasmas in the Joint European Torus with the ITER-like wall (JET-ILW) has been performed. The increase of the normalized energy confinement (defined as the ratio between thermal energy confinement and Bohm confinement time) with decreasing collisionality is observed. Moreover, at low collisionality, a confinement factor H-98, comparable to JET-C, is achieved. At high collisionality, the low normalized confinement is related to a degraded pedestal stability and a reduction in the density-profile peaking. The increase of normalized energy confinement is due to both an increase in the pedestal and in the core regions. The improvement in the pedestal is related to the increase of the stability. The improvement in the core is driven by (i) the core temperature increase via the temperature-profile stiffness and by (ii) the density-peaking increase driven by the low collisionality. Pedestal stability analysis performed with the ELITE (edge-localized instabilities in tokamak equilibria) code has a reasonable qualitative agreement with the experimental results. An improvement of the pedestal stability with decreasing collisionality is observed. The improvement is ascribed to the reduction of the pedestal width, the increase of the bootstrap current and the reduction of the relative shift between the positions of the pedestal density and pedestal temperature. The EPED1 model predictions for the pedestal pressure height are qualitatively well correlated with the experimental results. Quantitatively, EPED1 overestimates the experimental pressure by 15-35%. In terms of the pedestal width, a correct agreement (within 10-15%) between the EPED1 and the experimental width is found at low collisionality. The experimental pedestal width increases with collisionality. Nonetheless, an extrapolation to low-collisionality values suggests that the width predictions from the KBM constraint are reasonable for ITER.
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42. |
- Garcia Carrasco, Alvaro, 1989-, et al.
(författare)
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Plasma impact on diagnostic mirrors in JET
- 2017
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Ingår i: Nuclear Materials and Energy. - : ELSEVIER. - 2352-1791. ; 12, s. 506-512
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Tidskriftsartikel (refereegranskat)abstract
- Metallic mirrors will be essential components of all optical systems for plasma diagnosis in ITER. This contribution provides a comprehensive account on plasma impact on diagnostic mirrors in JET with the ITER-Like Wall. Specimens from the First Mirror Test and the lithium-beam diagnostic have been studied by spectrophotometry, ion beam analysis and electron microscopy. Test mirrors made of molybdenum were retrieved from the main chamber and the divertor after exposure to the 2013-2014 experimental campaign. In the main chamber, only mirrors located at the entrance of the carrier lost reflectivity (Be deposition), while those located deeper in the carrier were only slightly affected. The performance of mirrors in the JET divertor was strongly degraded by deposition of beryllium, tungsten and other species. Mirrors from the lithium-beam diagnostic have been studied for the first time. Gold coatings were severely damaged by intense arcing. As a consequence, material mixing of the gold layer with the stainless steel substrate occurred. Total reflectivity dropped from over 90% to less than 60%, i.e. to the level typical for stainless steel. (C) 2017 Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
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43. |
- Grigore, E., et al.
(författare)
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Thermo-mechanical properties of W/Mo markers coatings deposited on bulk W
- 2016
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Ingår i: Physica Scripta. - : IOP PUBLISHING LTD. - 0031-8949 .- 1402-4896. ; T167
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Tidskriftsartikel (refereegranskat)abstract
- In the present paper marker structures consisting of W/Mo layers were deposited on bulk W samples by using a modified CMSII method. This technology, compared to standard CMSII, prevents the formation of nano-pore structures at interfaces. The thicknesses of the markers were in the range 20-35 mu m to balance the requirements associated with the wall erosion in ITER and thermo-mechanical performances. The coatings structure and composition were evaluated by glow discharge optical emission spectrometry (GDOES), and energy dispersive x-ray spectroscopy measurements (EDX). The adhesion of the coatings to the substrate has been assessed by scratch test method. In order to evaluate their effectiveness as potential markers for fusion applications, the marker coatings have been tested in an electron beam facility at a temperature of 1000 degrees C and a power density of about 3 MW m(-2). A number of 300 pulses with duration of 420 s (35 testing hours) were applied on the marker coated samples.
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44. |
- Heinola, K., et al.
(författare)
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Long-term fuel retention in JET ITER-like wall
- 2016
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Ingår i: Physica Scripta. - : Institute of Physics Publishing (IOPP). - 0031-8949 .- 1402-4896. ; T167
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Tidskriftsartikel (refereegranskat)abstract
- Post-mortem studies with ion beam analysis, thermal desorption, and secondary ion mass spectrometry have been applied for investigating the long-term fuel retention in the JET ITERlike wall components. The retention takes place via implantation and co-deposition, and the highest retention values were found to correlate with the thickness of the deposited impurity layers. From the total amount of retained D fuel over half was detected in the divertor region. The majority of the retained D is on the top surface of the inner divertor, whereas the least retention was measured in the main chamber on the mid-plane of the inner wall limiter. The recessed areas of the inner wall showed significant contribution to the main chamber total retention. Thermal desorption spectroscopy analysis revealed the energetic T from DD reactions being implanted in the divertor. The total T inventory was assessed to be >0.3 mg.
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45. |
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46. |
- Johansson, M, et al.
(författare)
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A Prospective Study of Genetic Variants in Infants with Congenital Unilateral Sensorineural Hearing Loss
- 2023
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Ingår i: Journal of clinical medicine. - : MDPI AG. - 2077-0383. ; 12:2
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Tidskriftsartikel (refereegranskat)abstract
- Children with unilateral sensorineural hearing loss (uSNHL) have a high risk of speech-language delays and academic difficulties. Still, challenges remain in the diagnosis of uSNHL. With a prospective cross-sectional design, 20 infants were consecutively recruited from a universal newborn hearing screening program and invited to genetic testing. Eighteen of the subjects agreed to genetic testing, 15 subjects with OtoSCOPE® v.9 screening 224 genes, and four subjects underwent targeted testing, screening for chromosomal abnormalities or 105–137 gene mutations. The genetic results were described together with the 20 infants’ previously published auditory profiles and imaging results. Genetic causes for the uSNHL were found in 28% of subjects (5/18) including CHARGE syndrome (CHD7), autosomal recessive non-syndromic hearing loss (GJB2), Townes–Brocks syndrome (SALL1), Pendred Syndrome (SLC26A4) and Chromosome 8P inverted duplication and deletion syndrome. In subjects with comorbidities (malformation of fingers, anus, brain, and heart), 100% were diagnosed with a genetic cause for uSNHL (3/3 subjects), while 13% (2/15 subjects) were diagnosed without comorbidities observed at birth (p = 0.002). Genetic testing for congenital uSNHL is currently efficient for alleged syndromes, whereas genetic variants for non-syndromic congenital uSNHL need further research.
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47. |
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48. |
- Lerche, E., et al.
(författare)
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Sawtooth pacing with on-axis ICRH modulation in JET-ILW
- 2017
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Ingår i: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 57:3
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Tidskriftsartikel (refereegranskat)abstract
- A novel technique for sawteeth control in tokamak plasmas using ion-cyclotron resonance heating (ICRH) has been developed in the JET-ILW tokamak. Unlike previous ICRH methods, that explored the destabilization of the internal kink mode when the radio-frequency (RF) wave absorption was placed near the q = 1 surface, the technique presented here consists of stabilizing the sawteeth as fast as possible by applying the ICRH power centrally and subsequently induce a sawtooth crash by switching it off at the appropriate instant. The validation of this method in JET-ILW L-mode discharges, including preliminary tests in H-mode plasmas, is presented.
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49. |
- Loarte, A., et al.
(författare)
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H-mode plasmas in the pre-fusion power operation 1 phase of the ITER research plan
- 2021
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 61:7
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Tidskriftsartikel (refereegranskat)abstract
- The optimum conditions for access to and sustainment of H-mode plasmas and their expected plasma parameters in the pre-fusion power operation 1 (PFPO-1) phase of the ITER research plan, where the additional plasma heating will be provided by 20 MW of electron cyclotron heating, are assessed in order to identify key open R&D issues. The assessment is performed on the basis of empirical and physics-based scalings derived from present experiments and integrated modelling of these plasmas including a range of first-principle transport models for the core plasma. The predictions of the integrated modelling of ITER H-mode plasmas are compared with ITER-relevant experiments carried out at JET (low-collisionality high-current H modes) and ASDEX Upgrade (significant electron heating) for both global H-mode properties and scale lengths of density and temperature profiles finding reasonable agreement. Specific integration issues of the PFPO-1 H-mode plasma scenarios are discussed taking into account the impact of the specificities of the ITER tokamak design (level of ripple, etc).
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50. |
- Maggi, C. F., et al.
(författare)
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Pedestal confinement and stability in JET-ILW ELMy H-modes
- 2015
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Ingår i: Nuclear Fusion. - : Institute of Physics Publishing (IOPP). - 0029-5515 .- 1741-4326. ; 55:11
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Tidskriftsartikel (refereegranskat)abstract
- New experiments in 2013-2014 have investigated the physics responsible for the decrease in H-mode pedestal confinement observed in the initial phase of JET-ILW operation (2012 Experimental Campaigns). The effects of plasma triangularity, global beta and neutrals on pedestal confinement and stability have been investigated systematically. The stability of JET-ILW pedestals is analysed in the framework of the peeling-ballooning model and the model assumptions of the pedestal predictive code EPED. Low D neutrals content in the plasma, achieved either by low D-2 gas injection rates or by divertor configurations with optimum pumping, and high beta are necessary conditions for good pedestal (and core) performance. In such conditions the pedestal stability is consistent with the peeling-ballooning paradigm. Moderate to high D-2 gas rates, required for W control and stable H-mode operation with the ILW, lead to increased D neutrals content in the plasma and additional physics in the pedestal models may be required to explain the onset of the ELM instability. The changes in H-mode performance associated with the change in JET wall composition from C to Be/W point to D neutrals and low-Z impurities playing a role in pedestal stability, elements which are not currently included in pedestal models. These aspects need to be addressed in order to progress towards full predictive capability of the pedestal height.
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