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- Blomgren, Bo, et al.
(författare)
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A computerised, unbiased method for epithelial measurement
- 2004
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Ingår i: Micron. - Amsterdam : Elsevier. - 0968-4328 .- 1878-4291. ; 35, s. 319-329
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveTo develop and evaluate a standardised method for unbiased measurements of epithelial thickness taking the variability of the dermal papillae in consideration.MethodsA computer-assisted measurement program suitable for haematoxylin and eosin routine stained specimens has been developed.ResultsThe developed program was designed to measure four different distance parameters, taking the number, height and width of dermal papillae into account. The measurement program gave very accurate results compared with manual measurements. The measurement results can be presented as tables or star graphs, and the results can be further processed by multivariate analysis.ConclusionThe computer-assisted measurement program is considered to be a valuable and reliable tool for measurements of epithelial thickness, irrespectively of the variability of the epithelial morphology. Since length, size and number of the papillae may change with certain pathological conditions, age and also under hormonal influence, this method can be a helpful diagnostic tool.
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| 5. |
- Hidvegi, Attila, et al.
(författare)
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A high-speed data acquisition system for segmented Ge-detectors
- 2007
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Ingår i: 2007 IEEE Nuclear Science Symposium Conference Record. - : IEEE. - 1424409233 - 9781424409235 - 9781424409228 ; , s. 536-537
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Konferensbidrag (refereegranskat)abstract
- When using segmented Ge-detectors for gamma ray tracking it is necessary to determine the segment pulse shapes with high accuracy. A high-speed data acquisition system with many channels, high precision and with high sampling rate is required. There are also many other applications for such a system. Our system uses high performance FPGAs (Xilinx Virtex-V [2]) to cope with the data rates delivered by the high speed ADC chosen (Atmel 2Gsps, 10 bits) and to make all the data processing onboard in real time. Each board contains four such ADCs, which can either handle four channels up to full speed, or achieve higher sampling rates with interleaving. The boards can communicate with each other over different types of high-speed communication links. Control and monitoring is implemented with embedded processors. The processed result will be transmitted over Ethernet to final storage. The project introduces many challenging issues: signal integrity, ADC performance, interfacing ADCs to the FPGA, synchronisation of ADCs across the entire system, implementing flexible processing algorithms, high speed interconnection between boards and managing the significant heat generation. This is an ongoing project with interesting potentials for the future.
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| 6. |
- Hidvegi, Attila, et al.
(författare)
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A high-speed data acquisition system for segmented Ge-detectors
- 2007
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Ingår i: 2006 IEEE Nuclear Science Symposium Conference Record, Vol 1-6. - : IEEE. - 1424405610 - 9781424405619 - 1424405602 ; , s. 999-1001
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Konferensbidrag (refereegranskat)abstract
- When using segmented Ge-detectors for gamma ray tracking it is necessary to determine the segment pulse shapes with high accuracy. A high-speed data acquisition system with many channels, high precision and with high sampling rate is required. To find the optimum performance, we are investigating what can be achieved by a system with extremely high sampling rates, 10 bits @2GS/s. There are many other applications for such a system. Higher sampling rates usually mean lower bit resolution of the ADC, but with oversampling we expect to achieve a very good energy and time resolution. The system uses high performance FPGAs (Xilinx Virtex-IV) to cope with the data rates delivered by the high speed ADCs and to make all the data processing onboard in real time. Control and monitoring is implemented in an embedded soft processor. This processor is also in charge of the offboard gigabit Ethernet communication. The final system will consist of several separate boards, each with a number of input channels that will have to communicate with each other in real time over a high-speed communication link. The processed result will be transmitted over Ethernet to final storage. The project introduces many challenging issues, which are being addressed in turn with different prototype designs. These issues are: the ADC performance, interfacing the ADCs to the FPGA, implementing the flexible processing algorithms and high speed interconnection between the boards.
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| 8. |
- Johannesson, Ulrika, et al.
(författare)
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Steroid receptor expression and morphology in provoked vestibulodynia
- 2008
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Ingår i: American Journal of Obstetrics and Gynecology. - St. Louis : C.V. Mosby. - 0002-9378 .- 1097-6868. ; 198:3, s. 311.e1-311.e6
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Tidskriftsartikel (refereegranskat)abstract
- Objective: This study was undertaken to survey the steroid receptor expression and morphology in the vulvar vestibular mucosa in women with provoked vestibulodynia.Study Design: Fourteen patients and 25 controls without oral contraceptives were included. Vestibular biopsy specimens were obtained and analyzed by using immunohistochemistry, followed by computerized image analysis of estrogen receptors greek small letter alpha and β, progesterone receptors A and B, glucocorticoid receptor, androgen receptor, and the proliferation marker Ki67. The morphology was estimated by measuring 4 parameters in the epithelium.Results: There was a significantly higher expression of estrogen receptor greek small letter alpha in both the epithelium (P = .04) and the stroma (P = .02) in the patient specimens compared with the controls. There were no significant differences in the other analyses performed.Conclusion: There is an increased expression of estrogen receptor greek small letter alpha in the vestibular mucosa but the epithelial morphology seems unaffected in women with provoked vestibulodynia. Further studies regarding plausible associations to neurogenic inflammation are needed.
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| 9. |
- Johannesson, Ulrika, et al.
(författare)
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The vulval vestibular mucosa - morphological effects of oral contraceptives and menstrual cycle
- 2007
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Ingår i: British Journal of Dermatology. - Oxford : Blackwell Publishing. - 0007-0963 .- 1365-2133. ; 157:3, s. 487-493
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundAn erythematous and hypersensitive vestibular mucosa has been observed during the use of combined oral contraceptives (COC). Hormonal effects on the vestibular morphology have not been studied.ObjectivesOur aim was to evaluate the morphology of the vulval vestibular mucosa during the influence of COC and during the menstrual cycle.MethodsForty-five healthy women (20 using COC and 25 not using COC) were included. A 6-mm punch biopsy was obtained from the right posterior vestibule on days 7-11 of the menstrual cycle. A corresponding biopsy was taken 2 weeks later in 16 women without COC. The epithelial morphology was estimated by measuring interdermal papilla distance, dermal papilla to surface, from basal layer to surface and width of dermal papillae. A histopathological assessment was made.ResultsThe vulval vestibular mucosa of women using COC displayed a larger distance between the dermal papillae (P = 0·04) and a larger space from the dermal papillae to the epithelial surface (P = 0·03) compared with controls in the follicular phase. Women without COC displayed a larger interdermal papilla distance in the luteal phase compared with the follicular phase, P = 0·02. Histopathology showed more superficial blood vessels in the COC users (P < 0·01).ConclusionsThe vulval vestibular mucosa of women with COC display an altered morphological pattern with shallow and sparse dermal papillae compared with the follicular phase. Similar findings are seen in women without COC during the luteal phase which indicate a gestagenic effect on the mucosa. Associations between the morphological pattern and changes in mucosal mechanical sensitivity require further studies.
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| 11. |
- Singh, B., et al.
(författare)
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Study of doubly strange systems using stored antiprotons
- 2016
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Ingår i: Nuclear Physics A. - : Elsevier. - 0375-9474 .- 1873-1554. ; 954, s. 323-340
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Tidskriftsartikel (refereegranskat)abstract
- Bound nuclear systems with two units of strangeness are still poorly known despite their importance for many strong interaction phenomena. Stored antiprotons beams in the GeV range represent an unparalleled factory for various hyperon-antihyperon pairs. Their outstanding large production probability in antiproton collisions will open the floodgates for a series of new studies of systems which contain two or even more units of strangeness at the PANDA experiment at FAIR. For the first time, high resolution gamma-spectroscopy of doubly strange Lambda Lambda-hypernuclei will be performed, thus complementing measurements of ground state decays of Lambda Lambda-hypernuclei at J-PARC or possible decays of particle unstable hypernuclei in heavy ion reactions. High resolution spectroscopy of multistrange Xi(-) -atoms will be feasible and even the production of Omega(-) -atoms will be within reach. The latter might open the door to the vertical bar S vertical bar = 3 world in strangeness nuclear physics, by the study of the hadronic Omega(-) -nucleus interaction. For the first time it will be possible to study the behavior of Xi(+) in nuclear systems under well controlled conditions.
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| 12. |
- Varenhorst, Christoph, et al.
(författare)
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Timing Of Pci In Patients With Non-St-Elevation Myocardial Infarction : A Swedeheart Study
- 2016
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Ingår i: Journal of the American College of Cardiology. - Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden. Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.. - 0735-1097 .- 1558-3597. ; 67:13, s. 44-44
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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